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PSMA3 and IKBKG
Number of citations of the paper that reports this interaction (PubMedID
20098747
)
50
Data Source:
BioGRID
(pull down)
PSMA3
IKBKG
Description
proteasome 20S subunit alpha 3
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Alpha-subunit Complex
Extracellular Exosome
Ubiquitin Ligase Complex
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Protein-containing Complex
Mitotic Spindle
Molecular Function
Protein Binding
Ubiquitin Protein Ligase Binding
Protein Binding
Zinc Ion Binding
Protein Domain Specific Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
K63-linked Polyubiquitin Modification-dependent Protein Binding
Linear Polyubiquitin Binding
Transferrin Receptor Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
B Cell Homeostasis
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Inflammatory Response
Immune Response
DNA Damage Response
Canonical NF-kappaB Signal Transduction
Response To Virus
Positive Regulation Of Gene Expression
Positive Regulation Of Macroautophagy
Defense Response To Bacterium
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Anoikis
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Establishment Of Vesicle Localization
Protein-containing Complex Assembly
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
Antigen processing: Ub, ATP-independent proteasomal degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
SUMOylation of immune response proteins
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Ub-specific processing proteases
Ovarian tumor domain proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Phenethyl Isothiocyanate
AGRO100
Tarenflurbil
Diseases
Incontinentia pigmenti
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema
GWAS
Brain morphology (MOSTest) (
32665545
)
Mean corpuscular hemoglobin (
27863252
)
Mean corpuscular volume (
27863252
)
Red blood cell count (
32888494
)
Hemoglobin levels (
26366553
)
Interacting Genes
120 interacting genes:
ADGRL1
APLN
ATN1
ATP6V0C
AURKB
BTN2A2
BTRC
C1orf105
CCDC69
CCL28
CDK6
CDKN1A
CEBPA
CIP2A
CRB3
CRYAB
CSNK2A1
CST2
CTBP1-DT
CYBA
DDX5
DGLUCY
DMC1
DMRT3
DVL1
EGR1
FAM171A2
FAM218A
FAM83A
FBXL18
FNDC3B
FOS
FRAT1
GATA2
GATA3
GFI1B
GORASP2
HHEX
HSPB1
IKBKG
ILF3
IQCE
KIF1A
KIRREL2
KIRREL3-AS3
KRAS
KRTAP19-5
KRTAP26-1
KRTAP8-1
LASP1
LBP
LETM1
LINC00908
LINC02913
MDM2
MIA2
NEU4
NOL4L-DT
NPBWR2
NPPB
NUMBL
OLIG2
OSR2
PATL1
PCOTH
PLK1
PML
POMP
PRELID3A
PRNP
PRR13
PRR3
PRRC2A
PSMA1
PSMA2
PSMA4
PSMA6
PSMA7
PSMB10
PSMB5
PTPN23
PWWP2B
PWWP3A
RAB3IL1
RAD54L2
RAMAC
RBFOX2
RERE
RFT1
RTP5
RUSC1-AS1
SERF2
SF1
SH3KBP1
SLAIN1
SLC22A23
SNRPB
SNRPC
SNRPF
SPATA8
SRPK2
STUB1
STX11
STX1A
STX4
STX6
TBC1D16
TBX6
TCF7L2
TINCR
TP53
TRIB3
UBD
URB1-AS1
VPS37C
XRN2
YPEL3
ZNF366
ZNF385C
ZNF688
241 interacting genes:
ABCA1
ACBD6
ADAP2
AIP
ALK
AMMECR1L
APRT
ARF4
ARF5
ARF6
ARGLU1
ARHGDIA
ARL6IP4
ARPP19
AVPI1
BCL10
BIRC2
BRME1
C19orf12
CALB1
CARD10
CARD11
CARD8
CASP6
CASP8
CCHCR1
CDC37
CDK2
CDKN1A
CETN3
CHUK
CLIC1
CNOT7
COPS3
CPNE2
CREBBP
CUEDC1
CWF19L2
CYLD
DAPK1
DDIT3
DDX19B
DNAJC8
DYNC1LI1
EEF1A1
EGFR
EGLN3
EIF1AX
ENKD1
EPHA4
FADD
FGR
FLT3
FLT4
FRMD8
GADD45G
GADD45GIP1
GCC1
GEMIN2
GFAP
GIT2
GLO1
GNGT1
GPKOW
GRK4
GSK3B
GTF2E1
GUCY1A1
GYG2
H1-0
HBZ
HCLS1
HDDC2
HIF1A
HLA-DQA1
HPCAL1
HPD
HSP90AA1
HSP90AB1
HSPA1A
HSPA4
ID1
ID3
IKBKB
INO80E
IRAK1
IRAK4
ITK
JAK2
JAK3
KANSL2
KIR3DX1
KRT18
KRT8
LCK
LENG8
LGALS2
LMCD1
LPXN
LUC7L2
LZIC
LZTR1
MACROD1
MAFIP
MAP3K14
MAP3K2
MAPRE1
MARCHF2
MCM10
MCM7
MED7
MERTK
MLLT6
MPRIP
MYD88
MYL5
MYO5C
MZT2A
NAP1L5
NCOA3
NECAB3
NFKB1
NFKB2
NFKBIA
NFKBIB
NHP2
NRARP
NRBF2
NTMT1
ODAM
OSBPL10
OSGIN1
PA2G4
PARP1
PCK1
PDCL
PFDN5
PHF7
PIM2
PLEKHJ1
PNMA8A
POLR2B
POLR2D
POLR2E
POLR3A
PPM1B
PRKCB
PRKCI
PRKCQ
PRKD3
PRKDC
PRKN
PRPF18
PSMA3
PSMB5
RAB11A
RAB11B
RAB8A
RALBP1
RBBP8
RBM34
RBM8A
RBP1
RET
RHOA
RIPK1
RIPK2
RNF11
RNF31
RNF34
RNF4
RNF7
ROR2
ROS1
RPL41
RPS12
RPS6KB2
SCLT1
SENP2
SEPTIN9
SGK1
SHTN1
SLU7
SNW1
SRC
SRPK1
SSX2IP
STK25
STX11
SUPT5H
SYT1
TAB1
TAB2
TAB3
TAF7
TANK
TARBP2
TAX1BP1
TBC1D7
TBK1
TCEANC
TCP10L
TCP11
TCP11L1
TEC
TEK
TMA16
TNF
TNFAIP3
TNFRSF1A
TNIP1
TNIP2
TPT1
TRAF3IP2
TRIM29
TRIM31
TRIM37
TRIM41
TRIOBP
TRPC4AP
TSLP
TTYH2
TUBG1
TXLNA
TYRO3
UBASH3A
UBB
UBC
UBE2D3
UBE2D4
UBE2I
USP2
VAMP3
WDR5
WWP1
ZBTB3
ZC3H12A
ZFAND5
ZNF587
ZNF835
ZZZ3
Entrez ID
5684
8517
HPRD ID
01463
02217
Ensembl ID
ENSG00000100567
ENSG00000269335
Uniprot IDs
A0A140VK43
P25788
A0A087X1B1
Q9Y6K9
PDB IDs
4R3O
4R67
5A0Q
5DSV
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
7AWE
7B12
7E55
7LXV
7NAN
7NAO
7NAP
7NAQ
7NHT
7PG9
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7V5G
7V5M
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8BZL
8CVR
8CVS
8CVT
8CXB
8JRI
8JRT
8JTI
8K0G
8QYJ
8QYL
8QYM
8QYN
8QYO
8QYS
8QZ9
8TM3
8TM4
8TM5
8TM6
8UD9
8USB
8USC
8YIX
8YIY
8YIZ
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
9HMN
2JVX
2JVY
3BRT
3BRV
3CL3
3FX0
4BWN
5AAY
5LDE
6MI3
6MI4
6XX0
6YEK
7T2U
7TV4
8U7C
9AZJ
Enriched GO Terms of Interacting Partners
?
Proteasome Core Complex
Proteasome Core Complex, Alpha-subunit Complex
Response To Gamma Radiation
Proteasome Complex
Cellular Response To Gamma Radiation
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of MiRNA Metabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of MiRNA Metabolic Process
Response To Ionizing Radiation
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Ubiquitin-dependent Protein Catabolic Process
Protein Binding
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Response To Gravity
Cellular Response To Ionizing Radiation
Regulation Of Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Molecular Function Activator Activity
Macromolecule Catabolic Process
Negative Regulation Of Cell Cycle
Nuclear Matrix
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Nucleoplasm
Protein Destabilization
Regulation Of Protein Stability
HMG Box Domain Binding
Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Proteolysis
Regulation Of Hormone Metabolic Process
Protein Catabolic Process
Negative Regulation Of Macromolecule Metabolic Process
SNAP Receptor Activity
Proteasomal Protein Catabolic Process
Cellular Response To Actinomycin D
Promoter-specific Chromatin Binding
Positive Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Cellular Senescence
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Cytoplasm
Protein Kinase Activity
Non-canonical NF-kappaB Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cytosol
Canonical NF-kappaB Signal Transduction
Kinase Activity
Regulation Of Immune Response
Regulation Of Innate Immune Response
Regulation Of Defense Response
Activation Of Innate Immune Response
Positive Regulation Of Defense Response
Positive Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Activation Of Immune Response
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune Response
Regulation Of Apoptotic Process
Positive Regulation Of Signaling
Intracellular Signal Transduction
Positive Regulation Of Innate Immune Response
Immune Response-activating Signaling Pathway
Protein Modification Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Immune Response-regulating Signaling Pathway
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Nucleotide Binding
Transferase Activity
Positive Regulation Of Cell Communication
Innate Immune Response-activating Signaling Pathway
Macromolecule Metabolic Process
Protein Tyrosine Kinase Activity
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Cytokine-mediated Signaling Pathway
Intracellular Receptor Signaling Pathway
Regulation Of Immune System Process
Protein Phosphorylation
Protein Binding
Regulation Of Protein Modification Process
Protein Metabolic Process
ATP Binding
Negative Regulation Of Programmed Cell Death
Phosphorylation
Nucleus
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Tagcloud (Intersection)
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