ZC3HAV1 and NXF1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		ZC3HAV1	NXF1
Description		zinc finger CCCH-type containing, antiviral 1	nuclear RNA export factor 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Late Endosome Cytosol	Transcription Export Complex Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Speck Nuclear RNA Export Factor Complex Nuclear Inclusion Body
	Molecular Function	RNA Binding NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Cadherin Binding Metal Ion Binding NAD+ Binding NAD+-protein Mono-ADP-ribosyltransferase Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Immune System Process Response To Virus Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Positive Regulation Of MRNA Catabolic Process Protein Poly-ADP-ribosylation Positive Regulation Of RIG-I Signaling Pathway	RNA Export From Nucleus MRNA Export From Nucleus Protein Transport Poly(A)+ MRNA Export From Nucleus MRNA Transport
Pathways		Signaling by BRAF and RAF1 fusions	Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript
Drugs
Diseases
GWAS		Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Multiple sclerosis ( 31604244) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		11 interacting genes: AKT1 APP FOXP1 KRTAP10-6 MDFI NXF1 OGT PCBP3 SNRPA SRSF11 USP7	138 interacting genes: ALDOA ALYREF APOBEC3C AUNIP BACH2 BECN1 BICD2 BIN3 BIRC2 BLMH BTBD18 C10orf55 C1orf35 CAMK2G CCDC120 CCDC196 CCDC197 CCDC7 CDYL2 CEBPA CEP55 CLK2 CLK3 CPSF7 CSNK2A1 CTTN DDX50 DHX9 DMRTB1 DVL3 ECSIT EIF4A3 ELAVL4 ESRRA EXOSC8 FAM9A FTO GFAP GOLGA6L9 GPBP1 GTPBP2 HNRNPUL1 HOMEZ HOXA1 HSF2BP IMPA1 IPO11 IPO4 ISY1-RAB43 KATNBL1 KCTD5 KCTD7 KIF24 KRT31 KRT40 LCE3E LDOC1 LUZP4 MAGOH MAP1A MAP1B MBD3L1 MID2 MRNIP MTUS2 NKAPD1 NME1 NME4 NUP153 NUP214 NUP62 NUP98 NXF2 NXF3 NXF5 NXT1 NXT2 PEG10 PIH1D2 PPP1R12C PRKAR1B PRPH PRR3 PRRC2B PURB QKI RAD51 RAE1 RALYL RAN RANBP2 RBFOX2 RBM15B RBM22 RBMX RBPMS REDIC1 RPRD1A SGTA SH2D3A SH3GLB2 SLAIN1 SNRPA SNW1 SPATC1L SRPK2 SRSF1 SRSF3 SRSF4 SRSF7 SRSF8 STRAP SYCP3 TBC1D14 TCP10L TEX9 TFIP11 THOC5 TIFA TNFAIP1 TNPO1 TNPO2 TRA2A TRA2B U2AF1 UBQLN1 UBQLN4 UPF3A VAPA VIM VPS28 WEE2-AS1 XIST ZBED2 ZC3HAV1 ZNF250 ZNF343 ZNF438
Entrez ID		56829	10482
HPRD ID		09534	04035
Ensembl ID		ENSG00000105939	ENSG00000162231
Uniprot IDs		C9J6P4 Q7Z2W4	Q59E96 Q9UBU9
PDB IDs		2X5Y 4X52 6UEI 6UEJ 7KZH 7TGQ 9BGL	1FO1 1FT8 1GO5 1JKG 1JN5 1KOH 1KOO 1OAI 2Z5K 2Z5M 3RW6 3RW7 4WYK 6E5U
Enriched GO Terms of Interacting Partners?		TORC1 Signaling TOR Signaling Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of TOR Signaling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Communication Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hemopoiesis Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Phosphatidylinositol-3,4,5-trisphosphate Binding Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Identical Protein Binding Cellular Response To Nerve Growth Factor Stimulus Nucleic Acid Binding Response To Nerve Growth Factor Nucleus Negative Regulation Of Gene Expression Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Cellular Response To Nutrient Levels Regulation Of TRNA Methylation Maintenance Of Protein Location In Cell Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Gluconeogenesis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly	MRNA Transport RNA Transport Nucleobase-containing Compound Transport RNA Binding RNA Export From Nucleus MRNA Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Export Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Metabolic Process RNA Splicing MRNA Processing Regulation Of MRNA Metabolic Process MRNA Export From Nucleus Nucleic Acid Binding RNA Processing Nucleus Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Metabolic Process RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Intracellular Transport Nucleic Acid Metabolic Process Nuclear RNA Export Factor Complex Nucleoplasm Positive Regulation Of RNA Splicing Identical Protein Binding Import Into Nucleus Protein Binding Cellular Localization Nuclear Localization Sequence Binding Nuclear Pore Spliceosomal Complex Catalytic Step 2 Spliceosome Protein Import Into Nucleus Nucleobase-containing Compound Metabolic Process Nuclear Speck Positive Regulation Of MRNA Splicing, Via Spliceosome Establishment Of Localization In Cell Protein Localization To Nucleus Exon-exon Junction Complex Establishment Of Protein Localization To Organelle Poly(A)+ MRNA Export From Nucleus Protein Localization To Organelle Nuclear Envelope Intracellular Protein Transport Negative Regulation Of MRNA Metabolic Process
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