ZC3HAV1 and PCBP3

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		ZC3HAV1	PCBP3
Description		zinc finger CCCH-type containing, antiviral 1	poly(rC) binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Late Endosome Cytosol	Nucleus Cytoplasm Cytosol Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	RNA Binding NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Cadherin Binding Metal Ion Binding NAD+ Binding NAD+-protein Mono-ADP-ribosyltransferase Activity	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding C-rich Single-stranded DNA Binding
	Biological Process	Immune System Process Response To Virus Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Positive Regulation Of MRNA Catabolic Process Protein Poly-ADP-ribosylation Positive Regulation Of RIG-I Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Metabolic Process Viral RNA Genome Replication
Pathways		Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Multiple sclerosis ( 31604244) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)	A body shape index ( 34021172) Ankle injury ( 28957384) Daytime nap ( 33568662) Diffusing capacity of carbon monoxide ( 30694715) Insulin resistance/response ( 21901158) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Low myopia ( 33830181) Macular thickness ( 30535121) Myopia ( 27182965) Refractive error ( 32231278) Spatial processing ( 31596458) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		11 interacting genes: AKT1 APP FOXP1 KRTAP10-6 MDFI NXF1 OGT PCBP3 SNRPA SRSF11 USP7	17 interacting genes: APOBEC3C CELF4 DDIT4L HNRNPLL KRT81 MATR3 PTBP1 PTBP2 PUF60 QKI RBM47 RNF4 RUVBL1 SNRPA SREK1 SRSF3 ZC3HAV1
Entrez ID		56829	54039
HPRD ID		09534	10534
Ensembl ID		ENSG00000105939	ENSG00000183570
Uniprot IDs		C9J6P4 Q7Z2W4	P57721
PDB IDs		2X5Y 4X52 6UEI 6UEJ 7KZH 7TGQ 9BGL
Enriched GO Terms of Interacting Partners?		TORC1 Signaling TOR Signaling Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of TOR Signaling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Communication Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hemopoiesis Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Phosphatidylinositol-3,4,5-trisphosphate Binding Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Identical Protein Binding Cellular Response To Nerve Growth Factor Stimulus Nucleic Acid Binding Response To Nerve Growth Factor Nucleus Negative Regulation Of Gene Expression Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Cellular Response To Nutrient Levels Regulation Of TRNA Methylation Maintenance Of Protein Location In Cell Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Gluconeogenesis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly	Nucleic Acid Binding MRNA Processing Regulation Of RNA Splicing RNA Splicing RNA Binding MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome RNA Processing Regulation Of MRNA Processing MRNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Metabolic Process Regulation Of MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Pre-mRNA Binding Negative Regulation Of RNA Splicing Negative Regulation Of MRNA Metabolic Process MRNA Splice Site Recognition Macromolecule Metabolic Process Nucleus Ribonucleoprotein Complex Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process RNA Splicing, Via Transesterification Reactions Cytidine To Uridine Editing Base Conversion Or Substitution Editing Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process RNA Localization Regulation Of RNA Metabolic Process Regulation Of Metabolic Process MiRNA Binding Spliceosomal Complex Positive Regulation Of Gene Expression Positive Regulation Of RNA Splicing Regulation Of Nucleobase-containing Compound Metabolic Process Internal N(7)-methylguanine-containing RNA Reader Activity Regulation Of Retina Development In Camera-type Eye Negative Regulation Of Viral Genome Replication Positive Regulation Of Macromolecule Metabolic Process Poly-pyrimidine Tract Binding Protein-RNA Sequence-specific Adaptor Activity
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