CLDND1 and CXCR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDND1	CXCR1
Description		claudin domain containing 1	C-X-C motif chemokine receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Cell Surface Membrane Apical Plasma Membrane Anchoring Junction	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane
	Molecular Function	Protein Binding	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding
	Biological Process		Dendritic Cell Chemotaxis Chemotaxis Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Chemokine-mediated Signaling Pathway
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs			Ketoprofen
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245)	Basophil count ( 32888494) Diffusing capacity of carbon monoxide ( 30694715) Idiopathic intracranial hypertension ( 29608535) Inflammatory bowel disease ( 23128233 28067908) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 29403010) Smooth-surface caries ( 23470693) White blood cell count ( 29403010)
Interacting Genes		5 interacting genes: CXCR1 DRD2 GPR61 MTNR1B ZDHHC4	20 interacting genes: ADRA1A CDK1 CLDND1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 FATE1 GNA14 GNA15 GNAI2 IGFBP5 PDCD6IP PPBP TRARG1 TUBA1A UBE2C
Entrez ID		56650	3577
HPRD ID		12822	00908
Ensembl ID		ENSG00000080822	ENSG00000163464
Uniprot IDs		A0A0R4J2F2 Q9NY35	P25024
PDB IDs			1ILP 1ILQ 2LNL 6XMN 8IC0
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Circadian Sleep/wake Cycle, Sleep G Protein-coupled Receptor Signaling Pathway Regulation Of Circadian Sleep/wake Cycle Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Negative Regulation Of Protein Secretion Negative Regulation Of Hormone Secretion Receptor Internalization Regulation Of Behavior Ligand-independent Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Negative Regulation Of Secretion By Cell Regulation Of Circadian Rhythm Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Plasma Membrane Regulation Of Insulin Secretion Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Negative Regulation Of Dephosphorylation Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Negative Regulation Of Protein Localization Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Negative Regulation Of Secretion Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Protein Transport Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Receptor-mediated Endocytosis Positive Regulation Of Neurotransmitter Uptake Negative Regulation Of Establishment Of Protein Localization Regulation Of Locomotion Involved In Locomotory Behavior Signal Transduction Negative Regulation Of Dopamine Receptor Signaling Pathway Interleukin-8-mediated Signaling Pathway Interleukin-8 Binding Interleukin-8 Receptor Activity Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Neutrophil Chemotaxis Neutrophil Migration Granulocyte Chemotaxis Antimicrobial Humoral Response Granulocyte Migration CXCR Chemokine Receptor Binding Chemotaxis Cytokine Activity Locomotion Inflammatory Response Myeloid Leukocyte Migration Leukocyte Chemotaxis Humoral Immune Response Cell Migration Cell Motility Leukocyte Migration Killing Of Cells Of Another Organism Guanyl Nucleotide Binding G Protein-coupled Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Cell Killing Neutrophil Activation Heterotrimeric G-protein Complex Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Defense Response Defense Response To Symbiont Defense Response To Other Organism Response To Molecule Of Bacterial Origin Immune Response Cellular Response To Oxygen-containing Compound Cellular Response To Lipopolysaccharide GTP Binding Extracellular Region Cellular Response To Molecule Of Bacterial Origin G Protein-coupled Receptor Binding Protein Polymerization Cell Division Extracellular Space Response To Other Organism Microtubule Polymerization G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Cell Population Proliferation Response To Lipopolysaccharide Myeloid Leukocyte Activation D-glucose Transmembrane Transport Response To External Biotic Stimulus
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