CLDND1 and GPR61

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDND1	GPR61
Description		claudin domain containing 1	G protein-coupled receptor 61
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Cell Surface Membrane Apical Plasma Membrane Anchoring Junction	Endosome Plasma Membrane Endosome Membrane Membrane Receptor Complex
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Protein Binding Arrestin Family Protein Binding
	Biological Process		Signal Transduction G Protein-coupled Receptor Signaling Pathway Ligand-independent Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245)	Adult body size ( 32376654) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Chronotype ( 30696823) Hepcidin/ferritin ratio ( 27846281) Morning person ( 30696823) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Stearic acid (18:0) levels ( 23362303) Waist circumference ( 25673412)
Interacting Genes		5 interacting genes: CXCR1 DRD2 GPR61 MTNR1B ZDHHC4	20 interacting genes: APP ARL6IP6 ARLN ATP6V0B CLDND1 CTXN3 EMP3 FCER1G GJA8 GJB6 KLRC1 PLP1 PMP22 SCN3B SLC12A7 SLC13A4 STRIT1 TMEM147 TMEM218 TRARG1
Entrez ID		56650	83873
HPRD ID		12822	06077
Ensembl ID		ENSG00000080822	ENSG00000156097
Uniprot IDs		A0A0R4J2F2 Q9NY35	G4XH66 Q9BZJ8
PDB IDs			8KGK 8TB0 8TB7
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Circadian Sleep/wake Cycle, Sleep G Protein-coupled Receptor Signaling Pathway Regulation Of Circadian Sleep/wake Cycle Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Negative Regulation Of Protein Secretion Negative Regulation Of Hormone Secretion Receptor Internalization Regulation Of Behavior Ligand-independent Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Negative Regulation Of Secretion By Cell Regulation Of Circadian Rhythm Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Plasma Membrane Regulation Of Insulin Secretion Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Negative Regulation Of Dephosphorylation Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Negative Regulation Of Protein Localization Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Negative Regulation Of Secretion Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Protein Transport Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Receptor-mediated Endocytosis Positive Regulation Of Neurotransmitter Uptake Negative Regulation Of Establishment Of Protein Localization Regulation Of Locomotion Involved In Locomotory Behavior Signal Transduction Negative Regulation Of Dopamine Receptor Signaling Pathway Interleukin-8-mediated Signaling Pathway Interleukin-8 Binding Interleukin-8 Receptor Activity Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential	Membrane Plasma Membrane Gap Junction-mediated Intercellular Transport Cell-cell Signaling Signaling Bleb Assembly Intercellular Transport Cell Communication Transmembrane Transport Connexin Complex Gap Junction Channel Activity Chemical Synaptic Transmission Protein Localization To Membrane Gap Junction Trans-synaptic Signaling Synaptic Signaling
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