BACE1 and PCSK9

Number of citations of the paper that reports this interaction (PubMedID 18660751)
22

Data Source:
BioGRID (pull down)

		BACE1	PCSK9
Description		beta-secretase 1	proprotein convertase subtilisin/kexin type 9
Image
GO Annotations	Cellular Component	Lysosome Endosome Early Endosome Late Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Trans-Golgi Network Plasma Membrane Synaptic Vesicle Cell Surface Endosome Membrane Membrane Axon Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Neuronal Cell Body Membrane Raft Recycling Endosome Golgi-associated Vesicle Lumen Hippocampal Mossy Fiber To CA3 Synapse Presynapse	Extracellular Region Extracellular Space Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Cell Surface COPII-coated ER To Golgi Transport Vesicle Extrinsic Component Of External Side Of Plasma Membrane Endolysosome Membrane Perinuclear Region Of Cytoplasm PCSK9-LDLR Complex PCSK9-AnxA2 Complex
	Molecular Function	Amyloid-beta Binding Endopeptidase Activity Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Beta-aspartyl-peptidase Activity Hydrolase Activity Enzyme Binding Protein Serine/threonine Kinase Binding	RNA Binding Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Sodium Channel Inhibitor Activity Low-density Lipoprotein Particle Binding Signaling Receptor Inhibitor Activity Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Apolipoprotein Receptor Binding Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Response To Lead Ion Protein Processing Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Amyloid-beta Metabolic Process Modulation Of Chemical Synaptic Transmission Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Prepulse Inhibition Cellular Response To Copper Ion Cellular Response To Manganese Ion Presynaptic Modulation Of Chemical Synaptic Transmission Signaling Receptor Ligand Precursor Processing Cellular Response To Amyloid-beta Amyloid Fibril Formation	Kidney Development Liver Development Negative Regulation Of Receptor Recycling Negative Regulation Of Receptor Internalization Positive Regulation Of Receptor Internalization Proteolysis Lipid Metabolic Process Triglyceride Metabolic Process Phospholipid Metabolic Process Apoptotic Process Lysosomal Transport Steroid Metabolic Process Cholesterol Metabolic Process Cellular Response To Starvation Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Processing Protein Autoprocessing Neurogenesis Neuron Differentiation Low-density Lipoprotein Receptor Particle Metabolic Process Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cellular Response To Insulin Stimulus Lipoprotein Metabolic Process Cholesterol Homeostasis Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Sodium Ion Import Across Plasma Membrane Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Pathways		Amyloid fiber formation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) VLDLR internalisation and degradation Post-translational protein phosphorylation LDL clearance
Drugs		MMI-175 CTS-21166 N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDE N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide 4-(4-FLUOROBENZYL)PIPERIDINE N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide 6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE 6-[2-(3'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINE N~3~-BENZYLPYRIDINE-2,3-DIAMINE N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE 4-(2-aminoethyl)-2-cyclohexylphenol 4-(2-aminoethyl)-2-ethylphenol 4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine (6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one 2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-one (2S)-1-(2,5-dimethylphenoxy)-3-morpholin-4-ylpropan-2-ol N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide N-[1-(2,6-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide (6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINE N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINE 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE Verubecestat	Alirocumab Evolocumab Inclisiran
Diseases			Hypercholesterolemia, autosomal dominant; Hyperlipoproteinemia, type IIa
GWAS		Cardiovascular disease risk factors ( 21779381) Diffusing capacity of carbon monoxide ( 30694715) Mean platelet volume ( 32888494)	Abdominal aortic aneurysm ( 32981348) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576) Carotid intima media thickness x smoking interaction ( 32117412) Cholesterol, total ( 25961943 20686565 28270201 26582766 24097068) Coronary artery disease ( 33020668 26343387 32469254 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) LDL cholesterol ( 24507774 26582766 30275531 26160806 25961943 24097068 23726366 20864672 20686565 18193043 19060906 18193044) LDL cholesterol levels ( 31087446 30698716 28334899 26690388 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 22286219) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 30718733 33339817 32154731) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 22916037 23823483) Mitochondrial DNA copy number ( 30704525) Myocardial infarction ( 33532862 26343387) Myocardial infarction (early onset) ( 19198609) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Response to statins (LDL cholesterol change) ( 22331829) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 29403010 28334899 26690388 30275531 33339817 31087446 30718733)
Interacting Genes		25 interacting genes: ADRB2 APP ATP1B1 BRI3 CMPK1 CSNK1D FBXO2 FURIN GGA1 GGA2 ITM2C KHSRP LRP1 MMP2 NCSTN PCSK9 PDIA3 PLSCR1 PSAP PSEN1 RANBP9 SELPLG STUB1 TNIP2 USP8	3 interacting genes: BACE1 BIRC2 LDLR
Entrez ID		23621	255738
HPRD ID		07255	07080
Ensembl ID		ENSG00000186318	ENSG00000169174
Uniprot IDs		A0A7P0TAB4 B7Z3K2 B7Z3Z4 P56817	A0A669KBG0 A0AAQ5BGX4 Q8NBP7
PDB IDs		1FKN 1M4H 1PY1 1SGZ 1TQF 1UJJ 1UJK 1W50 1W51 1XN2 1XN3 1XS7 1YM2 1YM4 2B8L 2B8V 2F3E 2F3F 2FDP 2G94 2HIZ 2HM1 2IQG 2IRZ 2IS0 2NTR 2OAH 2OF0 2OHK 2OHL 2OHM 2OHN 2OHP 2OHQ 2OHR 2OHS 2OHT 2OHU 2P4J 2P83 2P8H 2PH6 2PH8 2Q11 2Q15 2QK5 2QMD 2QMF 2QMG 2QP8 2QU2 2QU3 2QZK 2QZL 2VA5 2VA6 2VA7 2VIE 2VIJ 2VIY 2VIZ 2VJ6 2VJ7 2VJ9 2VKM 2VNM 2VNN 2WEZ 2WF0 2WF1 2WF2 2WF3 2WF4 2WJO 2XFI 2XFJ 2XFK 2ZDZ 2ZE1 2ZHR 2ZHS 2ZHT 2ZHU 2ZHV 2ZJH 2ZJI 2ZJJ 2ZJK 2ZJL 2ZJM 2ZJN 3BRA 3BUF 3BUG 3BUH 3CIB 3CIC 3CID 3CKP 3CKR 3DM6 3DUY 3DV1 3DV5 3EXO 3FKT 3H0B 3HVG 3HW1 3I25 3IGB 3IN3 3IN4 3IND 3INE 3INF 3INH 3IVH 3IVI 3IXJ 3IXK 3K5C 3K5D 3K5F 3K5G 3KMX 3KMY 3KN0 3KYR 3L38 3L3A 3L58 3L59 3L5B 3L5C 3L5D 3L5E 3L5F 3LHG 3LNK 3LPI 3LPJ 3LPK 3MSJ 3MSK 3MSL 3N4L 3NSH 3OHF 3OHH 3OOZ 3PI5 3QBH 3QI1 3R1G 3R2F 3RSV 3RSX 3RTH 3RTM 3RTN 3RU1 3RVI 3S2O 3S7L 3S7M 3SKF 3SKG 3TPJ 3TPL 3TPP 3TPR 3U6A 3UDH 3UDJ 3UDK 3UDM 3UDN 3UDP 3UDQ 3UDR 3UDY 3UFL 3UQP 3UQR 3UQU 3UQW 3UQX 3VEU 3VF3 3VG1 3VV6 3VV7 3VV8 3WB4 3WB5 3ZMG 3ZOV 4ACU 4ACX 4AZY 4B00 4B05 4B0Q 4B1C 4B1D 4B1E 4B70 4B72 4B77 4B78 4BEK 4BFD 4D83 4D85 4D88 4D89 4D8C 4DH6 4DI2 4DJU 4DJV 4DJW 4DJX 4DJY 4DPF 4DPI 4DUS 4DV9 4DVF 4EWO 4EXG 4FCO 4FGX 4FM7 4FM8 4FRI 4FRJ 4FRK 4FRS 4FS4 4FSE 4FSL 4GID 4GMI 4H1E 4H3F 4H3G 4H3I 4H3J 4HA5 4HZT 4I0D 4I0E 4I0F 4I0G 4I0H 4I0I 4I0J 4I0Z 4I10 4I11 4I12 4I1C 4IVS 4IVT 4J0P 4J0T 4J0V 4J0Y 4J0Z 4J17 4J1C 4J1E 4J1F 4J1H 4J1I 4J1K 4JOO 4JP9 4JPC 4JPE 4K8S 4K9H 4KE0 4KE1 4L7G 4L7H 4L7J 4LC7 4LXA 4LXK 4LXM 4N00 4PZW 4PZX 4R5N 4R8Y 4R91 4R92 4R93 4R95 4RCD 4RCE 4RCF 4RRN 4RRO 4RRS 4TRW 4TRY 4TRZ 4WTU 4WY1 4WY6 4X2L 4X7I 4XKX 4XXS 4YBI 4ZPE 4ZPF 4ZPG 4ZSM 4ZSP 4ZSQ 4ZSR 5CLM 5DQC 5ENK 5ENM 5EZX 5EZZ 5F00 5F01 5HD0 5HDU 5HDV 5HDX 5HDZ 5HE4 5HE5 5HE7 5HTZ 5HU0 5HU1 5I3V 5I3W 5I3X 5I3Y 5IE1 5KQF 5KR8 5MBW 5MCO 5MCQ 5MXD 5QCO 5QCP 5QCQ 5QCR 5QCS 5QCT 5QCU 5QCV 5QCW 5QCX 5QCY 5QCZ 5QD0 5QD1 5QD2 5QD3 5QD4 5QD5 5QD6 5QD7 5QD8 5QD9 5QDA 5QDB 5QDC 5QDD 5T1U 5T1W 5TOL 5UYU 5V0N 5YGX 5YGY 6BFD 6BFE 6BFW 6BFX 6C2I 6DHC 6DMI 6E3Z 6EJ2 6EJ3 6EQM 6FGY 6JSE 6JSF 6JSG 6JSN 6JT3 6JT4 6NV7 6NV9 6NW3 6OD6 6PZ4 6UVP 6UVV 6UVY 6UWP 6UWV 6WNY 7B1E 7B1P 7B1Q 7D2V 7D2X 7D36 7D5A 7DCZ 7F1D 7MYI 7MYR 7MYU 7N66	2P4E 2PMW 2QTW 2W2M 2W2N 2W2O 2W2P 2W2Q 2XTJ 3BPS 3GCW 3GCX 3H42 3M0C 3P5B 3P5C 3SQO 4K8R 4NE9 4NMX 4OV6 5OCA 5VL7 5VLA 5VLH 5VLK 5VLL 5VLP 6E4Y 6E4Z 6MV5 6OLZ 6OM0 6OM7 6U26 6U2F 6U2N 6U2P 6U36 6U38 6U3I 6U3X 7ANQ
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Protein Metabolic Process Early Endosome Astrocyte Activation Involved In Immune Response Response To Amyloid-beta Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Regulation Of Protein Metabolic Process Golgi Apparatus Regulation Of Signaling Lysosomal Membrane Cellular Response To Amyloid-beta Azurophil Granule Membrane Apolipoprotein Binding Regulation Of Cell Communication Regulation Of Amyloid Fibril Formation Astrocyte Activation Endosome Membrane Positive Regulation Of Macromolecule Metabolic Process Lysosome Amyloid-beta Metabolic Process Amyloid-beta Binding Endosome Endopeptidase Activity Regulation Of Primary Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Proteolysis Positive Regulation Of Programmed Cell Death Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Positive Regulation Of Metabolic Process Plasma Membrane Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Intracellular Transport Lysosomal Transport Regulation Of Metabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Peptidase Activity Gamma-secretase Complex Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Heparan Sulfate Binding Positive Regulation Of Apoptotic Signaling Pathway Modulation Of Chemical Synaptic Transmission Notch Receptor Processing Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Amyloid-beta Metabolic Process Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process FBXO Family Protein Binding Amyloid-beta Binding Receptor-mediated Endocytosis Involved In Cholesterol Transport Late Endosome PCSK9-LDLR Complex Golgi-associated Vesicle Lumen Beta-aspartyl-peptidase Activity Positive Regulation Of Protein K48-linked Ubiquitination Negative Regulation Of Astrocyte Activation Regulation Of Phosphatidylcholine Catabolic Process Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination XY Body Response To Bleomycin Positive Regulation Of Protein Monoubiquitination CD40 Receptor Complex Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Monoubiquitination Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Inflammatory Response Necroptotic Process Negative Regulation Of Amyloid Fibril Formation Intestinal Cholesterol Absorption Regulation Of Astrocyte Activation Early Endosome Negative Regulation Of Astrocyte Differentiation Positive Regulation Of Lysosomal Protein Catabolic Process Regulation Of Phosphatidylcholine Metabolic Process Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Lysosomal Protein Catabolic Process Very-low-density Lipoprotein Particle Receptor Activity Negative Regulation Of Receptor Recycling Cholesterol Import Clathrin Heavy Chain Binding Lipoprotein Particle Binding Negative Regulation Of Low-density Lipoprotein Particle Clearance Low-density Lipoprotein Particle Regulation Of Phospholipid Catabolic Process Low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Protein Catabolic Process In The Vacuole Intestinal Lipid Absorption Lipoprotein Catabolic Process Negative Regulation Of Microglial Cell Activation Sorting Endosome Endosome Membrane Low-density Lipoprotein Particle Clearance Negative Regulation Of Neuroinflammatory Response Golgi Apparatus
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