PRPH and KRT15

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRPH	KRT15
Gene Name		peripherin	keratin 15, type I
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intermediate Filament Neurofilament Membrane Photoreceptor Outer Segment Membrane C-fiber Type III Intermediate Filament Extracellular Vesicular Exosome	Nucleus Intermediate Filament Extracellular Vesicular Exosome
	Molecular Function	Structural Molecule Activity	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding
	Biological Process	Intermediate Filament Cytoskeleton Organization	Epidermis Development
Pathways
Drugs
Diseases
GWAS		Prostate cancer ( 21743467)
Protein-Protein Interactions		5 interactors: KRT15 LMNB1 MYO5A PRPH2 VIM	115 interactors: ABI2 ABI3 ABLIM1 AES ALS2CR11 AMOT AMOTL2 ANKRD36BP1 APC ARC ARFIP2 ATP5O BEX2 C10orf10 C1orf216 CALCOCO1 CCDC101 CCDC120 CCDC185 CCDC67 CCDC87 CCHCR1 CCNB1IP1 CCNC CEP57 COX5B CREB5 CYTH4 DGCR6L EPC1 EXOC8 FAM107A FAM110A GFAP GLYCTK HAUS1 HGS HMG20B HOXB6 IKBIP KANSL1 KIAA0408 KIAA1217 KIFC3 KLC3 KLC4 KRT18 KRT19 KRT20 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT73 KRT77 KRT79 KRT8 KRT80 KRT81 KRT86 LDOC1 LMO2 LMO4 LNX1 MAD2L1BP MBD3 MCM10 MORN3 MOS NEFL NIF3L1 NOC4L NUDT18 NUP54 OIP5 PCM1 PIK3R2 PKN1 PPP1R18 PRPF31 PRPH PSMA1 PSMB1 PSMC5 RAD51D RCOR3 RHPN1 RIBC1 RIBC2 SIRPA SMARCD1 SMARCE1 SPG21 SSX2IP TCHP TEKT4 TIMM8A TMSB4X TRIM42 TSG101 TUBGCP4 TXLNA TXLNB TXNDC11 USHBP1 USP2 WAC ZC2HC1C ZFYVE26 ZGPAT ZNF417 ZNF576 ZNF638
Entrez ID		5630	3866
HPRD ID		01365	01009
Ensembl ID			ENSG00000171346
Uniprot IDs		B3KWQ6 P41219	A8MT21 B3KVF5 P19012
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Actin Filament-based Movement Execution Phase Of Apoptosis Tissue Development Visual Perception Sensory Perception Of Light Stimulus Endoplasmic Reticulum Localization Vesicle Transport Along Actin Filament Response To Low Light Intensity Stimulus Epithelium Development Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Locomotion Involved In Locomotory Behavior Bergmann Glial Cell Differentiation Secretory Granule Localization Camera-type Eye Development Response To Light Intensity Eye Development Long-chain Fatty Acid Biosynthetic Process Melanin Biosynthetic Process Melanin Metabolic Process Intermediate Filament Organization Lens Fiber Cell Development Secondary Metabolite Biosynthetic Process Astrocyte Development Epithelial Cell Differentiation Sensory Organ Development Muscle Filament Sliding Actin-myosin Filament Sliding Actin Filament-based Process Melanosome Transport Lens Fiber Cell Differentiation Pigment Granule Transport Anatomical Structure Development Establishment Of Melanosome Localization Melanocyte Differentiation Intermediate Filament Cytoskeleton Organization Melanosome Localization Insulin Secretion Astrocyte Differentiation Intermediate Filament-based Process Actin-mediated Cell Contraction Neuroepithelial Cell Differentiation Sensory Perception Developmental Process SMAD Protein Signal Transduction Pigment Biosynthetic Process Cellular Pigmentation Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport	Organelle Organization Cytoskeleton Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cell Cycle Cell Cycle Process Intermediate Filament Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Cellular Component Assembly Microtubule-based Process Mitotic Cell Cycle Chromosome Organization Microtubule Cytoskeleton Organization Chromatin Organization Chromatin Modification Cellular Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G1 DNA Damage Checkpoint Intraciliary Transport Involved In Cilium Morphogenesis Anatomical Structure Development RNA Biosynthetic Process Negative Regulation Of Canonical Wnt Signaling Pathway Cell Cycle Checkpoint Transcription, DNA-templated Mitotic Cell Cycle Checkpoint Gene Expression Movement Of Cell Or Subcellular Component Chromatin Remodeling Regulation Of Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Negative Regulation Of Wnt Signaling Pathway RNA Metabolic Process Developmental Process Histone Acetylation Internal Peptidyl-lysine Acetylation Viral Process Peptidyl-lysine Acetylation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Canonical Wnt Signaling Pathway Internal Protein Amino Acid Acetylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process
Tagcloud ?		accumulated albeit autoantibodies autoreactive b c57bl dynamics epitope follicular frequencies genesis heterogeneous infiltrating insulitis invaded islet islets isotype likewise octameric peripherin peritoneum prediabetic preferentially proliferates spleen subsets switched unfolded	17beta 3a additive canonical chemotherapeutic chosen combinatorial communications cooperation cooperative doxorubicin epha2 ers flt1 fuorouracil gdnf inpp5d mcf7 microarrays noncanonical notch1 nutlin responsiveness searches silenced sox9 tlr5 transcriptome vegfr
Tagcloud (Difference) ?		accumulated albeit autoantibodies autoreactive b c57bl dynamics epitope follicular frequencies genesis heterogeneous infiltrating insulitis invaded islet islets isotype likewise octameric peripherin peritoneum prediabetic preferentially proliferates spleen subsets switched unfolded	17beta 3a additive canonical chemotherapeutic chosen combinatorial communications cooperation cooperative doxorubicin epha2 ers flt1 fuorouracil gdnf inpp5d mcf7 microarrays noncanonical notch1 nutlin responsiveness searches silenced sox9 tlr5 transcriptome vegfr
Tagcloud (Intersection) ?