PRPH and FCHO1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRPH	FCHO1
Description		peripherin	FCH and mu domain containing endocytic adaptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Intermediate Filament Plasma Membrane Membrane Axon Cell Projection Perikaryon Type III Intermediate Filament Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Postsynaptic Endocytic Zone
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding	Protein Binding AP-2 Adaptor Complex Binding
	Biological Process	Intermediate Filament Organization	Endocytosis Clathrin Coat Assembly T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Clathrin-dependent Endocytosis
Pathways			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Prostate cancer ( 21743467) Sural nerve amplitude potential ( 30992453)	Basophil count ( 32888494) Coronary artery disease ( 29212778) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Monocyte percentage of white cells ( 32888494) Myocardial infarction ( 33532862)
Interacting Genes		34 interacting genes: CDC37 CT55 DDX6 DES FCHO1 INCA1 KIFC3 KRT14 KRT15 KRT16 KRT20 KRT24 KRT27 KRT31 LCA5L LENG1 LMNB1 LNX1 MAGOHB MYO5A NXF1 PIAS2 PPP1R13B PPP1R18 PRKAA2 PRPH2 PSMA1 TCEA2 TCP10L TTC23 VIM ZC4H2 ZMAT2 ZNF572	51 interacting genes: ACVR1 APP BYSL CCDC13 CFTR CSNK2A1 CWF19L2 DAB2 DDX6 DNAJC5 ELOA EPS15L1 EXOSC5 FBXL7 GRB7 GUCD1 ITSN1 KAT5 KPRP KRTAP10-1 KRTAP10-5 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP4-12 KRTAP6-1 KRTAP6-3 LGALS14 MAB21L3 NCK1 PCGF1 PHETA1 PHLDA2 PICALM PLAC8 PLSCR4 PRPF3 PRPH PTK6 SH2D4A SMURF1 SRPK2 SYTL4 TCEA2 TCEANC TGFB1 TRIM42 TSPAN4 ZBTB16 ZBTB24 ZNF688
Entrez ID		5630	23149
HPRD ID		01365	16887
Ensembl ID		ENSG00000135406	ENSG00000130475
Uniprot IDs		B3KWQ6 P41219	A0A0C3SFZ9 A0A8V8TMX9 A0A8V8TNC3 A0A8V8TPM7 B7ZAZ3 M0QYA9 O14526
PDB IDs			7OHI
Enriched GO Terms of Interacting Partners?		Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Structural Constituent Of Skin Epidermis Structural Constituent Of Cytoskeleton Keratin Filament Supramolecular Fiber Organization Structural Molecule Activity Morphogenesis Of An Epithelium Tissue Morphogenesis Cytoskeleton Organization Epithelial Cell Differentiation Keratin Filament Binding Cytoskeleton Extracellular Exosome Intermediate Filament Cytoskeleton Epidermis Development Protein Binding Organelle Organization Hair Cycle Scaffold Protein Binding Cytoplasmic Stress Granule Nuclear Envelope Organization	Intermediate Filament Clathrin-coated Pit Protein Targeting To Vacuole Involved In Autophagy Endosome To Plasma Membrane Transport Vesicle Regulation Of SMAD Protein Signal Transduction Low-density Lipoprotein Particle Receptor Binding Cytosol Positive Regulation Of Aggrephagy Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Enamel Mineralization Clathrin Coat Of Coated Pit Keratin Filament Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Vesicle-mediated Transport Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Binding Regulation Of Growth Receptor Metabolic Process SMAD Binding Negative Regulation Of Protein Localization Protein Targeting To Vacuole Negative Regulation Of Growth
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