PROC and SERPINB6

Number of citations of the paper that reports this interaction (PMID 7548163)
6

Data Source:
HPRD (in vitro)

		PROC	SERPINB6
Gene Name		protein C (inactivator of coagulation factors Va and VIIIa)	serpin peptidase inhibitor, clade B (ovalbumin), member 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Golgi Lumen	Extracellular Space Cytoplasm Cytosol Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Proteolysis Blood Coagulation Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Leukocyte Migration	Negative Regulation Of Endopeptidase Activity
Pathways		Common Pathway Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Intrinsic Pathway Post-translational protein modification Removal of aminoterminal propeptides from gamma-carboxylated proteins Gamma-carboxylation of protein precursors Formation of Fibrin Clot (Clotting Cascade) Gamma carboxylation, hypusine formation and arylsulfatase activation Cell surface interactions at the vascular wall Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	Dissolution of Fibrin Clot
Drugs		Menadione Sodium Tetradecyl Sulfate
Diseases
GWAS		Protein C levels ( 20802025)
Protein-Protein Interactions		13 interactors: CP CSNK2B F2 F5 F8 GGCX PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1	6 interactors: F10 F2 KLK2 PLAU PLG PROC
Entrez ID		5624	5269
HPRD ID		01466	01413
Ensembl ID		ENSG00000115718	ENSG00000124570
Uniprot IDs		B4DPQ7 P04070	P35237
PDB IDs		1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Coagulation Platelet Activation Platelet Degranulation Leukocyte Migration Negative Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Response To Stress Negative Regulation Of Fibrinolysis Cell Activation Regulation Of Blood Coagulation Regulation Of Fibrinolysis Exocytosis Locomotion Negative Regulation Of Proteolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Protein Processing Negative Regulation Of Platelet Activation Regulation Of Wound Healing Regulation Of Protein Processing Cell Migration Movement Of Cell Or Subcellular Component Cell Motility Fibrinolysis Secretion By Cell Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Post-translational Protein Modification Acute-phase Response Positive Regulation Of Coagulation Response To Stimulus Secretion Positive Regulation Of Wound Healing Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Peptidase Activity Fetal Process Involved In Parturition Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Acute Inflammatory Response Negative Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Skeletal Muscle Cell Proliferation Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity	Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Peptidyl-glutamic Acid Carboxylation Regulation Of Blood Coagulation Blood Coagulation Hemostasis Regulation Of Wound Healing Fibrinolysis Regulation Of Body Fluid Levels Wound Healing Proteolysis Response To Wounding Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Post-translational Protein Modification Leukocyte Migration Cell Migration Positive Regulation Of Blood Coagulation Cell Motility Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Locomotion Protein Metabolic Process Movement Of Cell Or Subcellular Component Extracellular Matrix Disassembly Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To Stress Regulation Of Smooth Muscle Cell-matrix Adhesion Mononuclear Cell Migration Protein Activation Cascade Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Platelet Activation Regulation Of Cell-substrate Adhesion Peptidyl-amino Acid Modification Blood Coagulation, Extrinsic Pathway Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Astrocyte Differentiation Regulation Of Cell Proliferation Negative Regulation Of Platelet Activation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Trophoblast Giant Cell Differentiation Labyrinthine Layer Blood Vessel Development Muscle Cell Cellular Homeostasis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process
Tagcloud ?		a1 acad binds comai defective duncan hnrnp hnrnps interfering lai leader li linking mapped mhv natl participate pentanucleotide polypyrimidine ptb repeats ribonucleoprotein sci shuttles splicing strand ucuaa usa zhang	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 tymp wars
Tagcloud (Difference) ?		a1 acad binds comai defective duncan hnrnp hnrnps interfering lai leader li linking mapped mhv natl participate pentanucleotide polypyrimidine ptb repeats ribonucleoprotein sci shuttles splicing strand ucuaa usa zhang	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 tymp wars
Tagcloud (Intersection) ?