PROC and CP

Number of citations of the paper that reports this interaction (PubMedID 2105310)
0

Data Source:
HPRD (in vitro)

		PROC	CP
Description		protein C, inactivator of coagulation factors Va and VIIIa	ceruloplasmin
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen	Extracellular Region Extracellular Space Lysosomal Membrane Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Ferroxidase Activity Glutathione Peroxidase Activity Copper Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Metal Ions Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Metal Ion Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity Protein-folding Chaperone Binding
	Biological Process	Proteolysis Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier	Intracellular Copper Ion Homeostasis Intracellular Iron Ion Homeostasis Cellular Oxidant Detoxification
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Post-translational protein phosphorylation Iron uptake and transport
Drugs		Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human	Calcium Iron Zinc Silver Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Zinc chloride Zinc sulfate, unspecified form
Diseases		Inherited thrombophilia
GWAS		Blood protein levels ( 30072576) Protein C levels ( 20802025 25376901 28082259)	Subcutaneous adipose tissue ( 22589738)
Interacting Genes		15 interacting genes: CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1	8 interacting genes: ATP7A BTRC GAST HSP90AA1 LTF MPO PLG PROC
Entrez ID		5624	1356
HPRD ID		01466	00317
Ensembl ID		ENSG00000115718	ENSG00000047457
Uniprot IDs		B4DPC8 B4DPQ3 E7END6 P04070	A5PL27 P00450
PDB IDs		1AUT 1LQV 3F6U 3JTC 4DT7 6M3B 6M3C 8JRU 8JRV 9BVM	1KCW 2J5W 4EJX 4ENZ
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Negative Regulation Of Coagulation Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Platelet Alpha Granule Lumen Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Extracellular Region Biological Process Involved In Interaction With Symbiont Endoplasmic Reticulum Lumen Regulation Of Wound Healing Copper Ion Binding Regulation Of Response To Wounding Extracellular Exosome Negative Regulation Of Fibrinolysis Golgi Lumen Regulation Of Fibrinolysis Negative Regulation Of Platelet Activation Fibrinolysis Platelet Alpha Granule Protease Binding Protein Activation Cascade Blood Microparticle Protein Maturation Positive Regulation Of Blood Coagulation Regulation Of Biological Quality Positive Regulation Of Coagulation Killing By Host Of Symbiont Cells Heparin Binding Extracellular Matrix Negative Regulation Of Multicellular Organismal Process COPII-coated ER To Golgi Transport Vesicle Zymogen Activation Acute-phase Response Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Gamma-glutamyl Carboxylase Activity Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex	Phagocytic Vesicle Lumen Removal Of Superoxide Radicals Serine-type Peptidase Activity Immune System Process Serine-type Endopeptidase Activity Extracellular Region Response To Food Biological Process Involved In Interaction With Symbiont Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Superoxide Metabolic Process Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Defense Response To Fungus Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Protein Metabolic Process CTP Binding DATP Binding Response To Fungus Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Hypochlorous Acid Biosynthetic Process Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Tissue Remodeling P-type Divalent Copper Transporter Activity P-type Monovalent Copper Transporter Activity Cellular Oxidant Detoxification Reactive Oxygen Species Metabolic Process Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Peptidase Activity Response To Gold Nanoparticle Endopeptidase Activity Protein Phosphorylated Amino Acid Binding Secretory Granule Blood Coagulation Coagulation Cellular Detoxification Hemostasis Response To Nutrient Levels Superoxide Dismutase Copper Chaperone Activity Copper-dependent Protein Binding Copper Ion Export Rho GDP-dissociation Inhibitor Binding
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