PROC and SERPINA5

Number of citations of the paper that reports this interaction (PMID 11123896)
2

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		PROC	SERPINA5
Gene Name		protein C (inactivator of coagulation factors Va and VIIIa)	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Golgi Lumen	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Platelet Alpha Granule Platelet Dense Tubular Network Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein Complex Extracellular Vesicular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Glycosaminoglycan Binding Heparin Binding Phosphatidylcholine Binding Acrosin Binding
	Biological Process	Proteolysis Blood Coagulation Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Leukocyte Migration	Lipid Transport Spermatogenesis Fusion Of Sperm To Egg Plasma Membrane Blood Coagulation Negative Regulation Of Endopeptidase Activity
Pathways		Common Pathway Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Intrinsic Pathway Post-translational protein modification Removal of aminoterminal propeptides from gamma-carboxylated proteins Gamma-carboxylation of protein precursors Formation of Fibrin Clot (Clotting Cascade) Gamma carboxylation, hypusine formation and arylsulfatase activation Cell surface interactions at the vascular wall Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	Common Pathway Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs		Menadione Sodium Tetradecyl Sulfate
Diseases
GWAS		Protein C levels ( 20802025)
Protein-Protein Interactions		13 interactors: CP CSNK2B F2 F5 F8 GGCX PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1	20 interactors: ACR COPS6 F10 F11 F2 FGA FGB FGG HRSP12 KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 SEMG2 THBD
Entrez ID		5624	5104
HPRD ID		01466	03503
Ensembl ID		ENSG00000115718	ENSG00000188488
Uniprot IDs		B4DPQ7 P04070	B3KTV6 B4DDH1 B4DPC7 P05154
PDB IDs		1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7	1LQ8 1PAI 2HI9 2OL2 2PAI 3DY0
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Coagulation Platelet Activation Platelet Degranulation Leukocyte Migration Negative Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Response To Stress Negative Regulation Of Fibrinolysis Cell Activation Regulation Of Blood Coagulation Regulation Of Fibrinolysis Exocytosis Locomotion Negative Regulation Of Proteolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Protein Processing Negative Regulation Of Platelet Activation Regulation Of Wound Healing Regulation Of Protein Processing Cell Migration Movement Of Cell Or Subcellular Component Cell Motility Fibrinolysis Secretion By Cell Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Post-translational Protein Modification Acute-phase Response Positive Regulation Of Coagulation Response To Stimulus Secretion Positive Regulation Of Wound Healing Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Peptidase Activity Fetal Process Involved In Parturition Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Acute Inflammatory Response Negative Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Skeletal Muscle Cell Proliferation Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity	Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Blood Coagulation Hemostasis Regulation Of Wound Healing Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Plasminogen Activation Fibrinolysis Proteolysis Protein Activation Cascade Positive Regulation Of Fibrinolysis Positive Regulation Of Heterotypic Cell-cell Adhesion Peptidyl-glutamic Acid Carboxylation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Endothelial Cell Apoptotic Process Protein Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Zymogen Activation Factor XII Activation Positive Regulation Of Vasoconstriction Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Stress Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Vasoconstriction Platelet Activation Positive Regulation Of Exocytosis Regulation Of Cell-substrate Adhesion Platelet Degranulation Negative Regulation Of Fibrinolysis Acute Inflammatory Response Plasma Kallikrein-kinin Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Peptide Hormone Secretion Protein Processing Positive Regulation Of Peptide Secretion Extracellular Matrix Disassembly Protein Polymerization Positive Regulation Of Hormone Secretion Negative Regulation Of Platelet Activation Response To Calcium Ion
Tagcloud ?		a1 acad binds comai defective duncan hnrnp hnrnps interfering lai leader li linking mapped mhv natl participate pentanucleotide polypyrimidine ptb repeats ribonucleoprotein sci shuttles splicing strand ucuaa usa zhang	across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pdzk1 pgr premenopausal progesterone rankl responsiveness rhythm runx1 tff1 tumours varies w1 w2 w3 windows
Tagcloud (Difference) ?		a1 acad binds comai defective duncan hnrnp hnrnps interfering lai leader li linking mapped mhv natl participate pentanucleotide polypyrimidine ptb repeats ribonucleoprotein sci shuttles splicing strand ucuaa usa zhang	across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pdzk1 pgr premenopausal progesterone rankl responsiveness rhythm runx1 tff1 tumours varies w1 w2 w3 windows
Tagcloud (Intersection) ?