PROC

Gene Name		protein C (inactivator of coagulation factors Va and VIIIa)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Golgi Lumen
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Proteolysis Blood Coagulation Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Leukocyte Migration
Pathways		Common Pathway Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Intrinsic Pathway Post-translational protein modification Removal of aminoterminal propeptides from gamma-carboxylated proteins Gamma-carboxylation of protein precursors Formation of Fibrin Clot (Clotting Cascade) Gamma carboxylation, hypusine formation and arylsulfatase activation Cell surface interactions at the vascular wall Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Menadione Sodium Tetradecyl Sulfate
Diseases
GWAS		Protein C levels ( 20802025)
Protein-protein Interactions		13 interactors: CP CSNK2B F2 F5 F8 GGCX PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1
Entrez ID		5624
HPRD ID		01466
Ensembl ID		ENSG00000115718
Uniprot IDs		B4DPQ7 P04070
PDB IDs		1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Coagulation Platelet Activation Platelet Degranulation Leukocyte Migration Negative Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Response To Stress Negative Regulation Of Fibrinolysis Cell Activation Regulation Of Blood Coagulation Regulation Of Fibrinolysis Exocytosis Locomotion Negative Regulation Of Proteolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Protein Processing Negative Regulation Of Platelet Activation Regulation Of Wound Healing Regulation Of Protein Processing Cell Migration Movement Of Cell Or Subcellular Component Cell Motility Fibrinolysis Secretion By Cell Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Post-translational Protein Modification Acute-phase Response Positive Regulation Of Coagulation Response To Stimulus Secretion Positive Regulation Of Wound Healing Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Peptidase Activity Fetal Process Involved In Parturition Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Acute Inflammatory Response Negative Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Skeletal Muscle Cell Proliferation Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity
Tagcloud ?		a1 acad binds comai defective duncan hnrnp hnrnps interfering lai leader li linking mapped mhv natl participate pentanucleotide polypyrimidine ptb repeats ribonucleoprotein sci shuttles splicing strand ucuaa usa zhang