PROC and PROCR

Number of citations of the paper that reports this interaction (PubMedID 10681521)
0

Data Source:
HPRD (in vitro)

		PROC	PROCR
Description		protein C, inactivator of coagulation factors Va and VIIIa	protein C receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen	Extracellular Region Extracellular Space Centrosome Plasma Membrane Focal Adhesion Cell Surface Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Proteolysis Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier	Blood Coagulation Hemostasis Negative Regulation Of Coagulation
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall
Drugs		Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human	Drotrecogin alfa Phosphatidylethanolamine Tetradecyl hydrogen sulfate (ester)
Diseases		Inherited thrombophilia
GWAS		Blood protein levels ( 30072576) Protein C levels ( 20802025 25376901 28082259)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anticoagulant levels ( 22216198) Appendicular lean mass ( 33097823) Coronary artery disease ( 29212778 33020668) D-dimer levels ( 21502573) Diastolic blood pressure ( 27618447) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Factor VII levels ( 20231535) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 23563607) Hemostatic factors and hematological phenotypes ( 22443383) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 33532862) Protein C levels ( 28082259 25376901 20802025) Prothrombin time ( 29403010 22703881) Thrombosis ( 26908601) Ulcerative colitis ( 23128233) Venous thromboembolism ( 25772935 31420334) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		15 interacting genes: CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1	3 interacting genes: DMTN PROC VKORC1
Entrez ID		5624	10544
HPRD ID		01466	02801
Ensembl ID		ENSG00000115718	ENSG00000101000
Uniprot IDs		B4DPC8 B4DPQ3 E7END6 P04070	Q9UNN8
PDB IDs		1AUT 1LQV 3F6U 3JTC 4DT7 6M3B 6M3C 8JRU 8JRV 9BVM	1L8J 1LQV 3JTC 4V3D 4V3E 6SNY 7OKS 7OKT 7OKU 7OKV 7Q5D 8C44
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Negative Regulation Of Coagulation Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Platelet Alpha Granule Lumen Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Extracellular Region Biological Process Involved In Interaction With Symbiont Endoplasmic Reticulum Lumen Regulation Of Wound Healing Copper Ion Binding Regulation Of Response To Wounding Extracellular Exosome Negative Regulation Of Fibrinolysis Golgi Lumen Regulation Of Fibrinolysis Negative Regulation Of Platelet Activation Fibrinolysis Platelet Alpha Granule Protease Binding Protein Activation Cascade Blood Microparticle Protein Maturation Positive Regulation Of Blood Coagulation Regulation Of Biological Quality Positive Regulation Of Coagulation Killing By Host Of Symbiont Cells Heparin Binding Extracellular Matrix Negative Regulation Of Multicellular Organismal Process COPII-coated ER To Golgi Transport Vesicle Zymogen Activation Acute-phase Response Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Gamma-glutamyl Carboxylase Activity Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex	Regulation Of Wound Healing Regulation Of Response To Wounding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Coagulation Blood Coagulation Hemostasis Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Negative Regulation Of Protein Targeting To Membrane Positive Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Peptidyl-serine Phosphorylation Spectrin-associated Cytoskeleton Platelet Dense Tubular Network Membrane Quinone Binding Cell Projection Membrane Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Negative Regulation Of Peptidyl-tyrosine Phosphorylation Endoplasmic Reticulum Tubular Network Organization Regulation Of Biological Quality Smooth Endoplasmic Reticulum Positive Regulation Of Fibroblast Migration Negative Regulation Of Focal Adhesion Assembly Regulation Of Establishment Of Endothelial Barrier Endoplasmic Reticulum Calcium Ion Homeostasis Spectrin Binding Cortical Cytoskeleton Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Coagulation Erythrocyte Development Regulation Of Protein Targeting To Membrane Actin Filament Capping Lamellipodium Assembly Negative Regulation Of Cell-matrix Adhesion Regulation Of Lamellipodium Assembly Negative Regulation Of Actin Filament Depolymerization Regulation Of Endothelial Cell Differentiation Regulation Of Fibroblast Migration Lamellipodium Organization Regulation Of Filopodium Assembly Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Actin Filament Depolymerization
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