PROP1 and PITX2

Number of citations of the paper that reports this interaction (PubMedID 9685346)
0

Data Source:
HPRD (in vitro)

		PROP1	PITX2
Description		PROP paired-like homeobox 1	paired like homeodomain 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Beta-catenin Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Ribonucleoprotein Complex Binding Sequence-specific DNA Binding Phosphoprotein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Central Nervous System Development Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Cell Migration Hypothalamus Cell Differentiation Pituitary Gland Development Adenohypophysis Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Gland Development Hypophysis Morphogenesis Somatotropin Secreting Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Vasculogenesis In Utero Embryonic Development Neuron Migration Extraocular Skeletal Muscle Development Outflow Tract Morphogenesis Atrioventricular Valve Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Pulmonary Myocardium Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Heart Development Skeletal Muscle Tissue Development Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Animal Organ Morphogenesis Wnt Signaling Pathway Subthalamic Nucleus Development Hypothalamus Cell Migration Pituitary Gland Development Lung Development Regulation Of Cell Migration Embryonic Camera-type Eye Development Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Vascular Associated Smooth Muscle Cell Differentiation Deltoid Tuberosity Development Regulation Of Cell Population Proliferation Odontogenesis Camera-type Eye Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Embryonic Digestive Tract Morphogenesis System Development Cardiac Muscle Tissue Development Cardiac Muscle Cell Differentiation Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Digestive System Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Ventricular Septum Morphogenesis Left Lung Morphogenesis Pulmonary Vein Morphogenesis Superior Vena Cava Morphogenesis Embryonic Heart Tube Left/right Pattern Formation Endodermal Digestive Tract Morphogenesis Iris Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Left/right Axis Specification
Pathways			TFAP2 (AP-2) family regulates transcription of other transcription factors
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Axenfeld-Rieger syndrome (ARS)
GWAS			Appendectomy ( 30392061) Atrial fibrillation ( 19597492 33990960 30061737 29892015 29290336 28416822 28416818 20173747 22544366) Atrial fibrillation/atrial flutter ( 17603472) Cardioembolic stroke (CCS and TOAST classification) ( 32047268) Cardioembolic stroke (CCS or TOAST classification) ( 32047268) Cardioembolic stroke (CCSc classification) ( 32047268) Cardioembolic stroke (CCSp classification) ( 32047268) Cardioembolic stroke (TOAST classification) ( 32047268) Cognitive decline rate in late mild cognitive impairment ( 26252872) Early onset atrial fibrillation ( 28460022) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Glaucoma (primary open-angle) ( 33627673) Heart failure ( 31919418) Incident atrial fibrillation ( 28416818) Intraocular pressure ( 29235454) Ischemic stroke ( 24262325 26708676) Ischemic stroke (cardioembolic) ( 26708676 27068588) Lung cancer ( 28604730) Prevalent atrial fibrillation ( 28416818) Sick sinus syndrome ( 33580673) Smoking status (heavy vs never) ( 26423011) Stroke (ischemic) ( 23041239)
Interacting Genes		54 interacting genes: ABHD11 ACTMAP ARSA BATF2 C1orf94 C6orf15 CFAP68 CIMIP2A COX6B2 CRYBA1 CYSRT1 DAZAP2 EFEMP2 FAM168A HDHD3 HESX1 HNRNPF HOXA1 INTS11 KHDC1 KRTAP13-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP6-3 KRTAP8-1 MAGED1 METTL15 METTL27 NR1D2 OLIG3 OXER1 P4HA3 PITX2 PLEKHB2 POU6F2 PSMB11 PSMB4 RNF144B RNF4 SMUG1 SPMIP6 SUMO1 TBX22 TEKT4 TEKT5 TENT5B TINAGL1 TLE5 TMEM42 TRIM42 UBE2I UFSP1 ZNF503	36 interacting genes: ATN1 CTNNB1 CYSRT1 DAZAP2 DYNLT1 HDAC1 HERC5 HEY1 HOXA1 KAT5 KRT34 KRTAP15-1 KRTAP19-5 KRTAP19-7 KRTAP3-3 KRTAP6-1 KRTAP7-1 LEF1 OIP5 PDLIM1 PFDN5 POU2AF1 PROP1 PSMB4 RBPMS SPMIP9 TINAGL1 TLE5 TRAF1 TRIB3 TRIM25 UFSP1 VGLL3 WWOX ZNF34 ZNHIT3
Entrez ID		5626	5308
HPRD ID		03325	03328
Ensembl ID		ENSG00000175325	ENSG00000164093
Uniprot IDs		A0A0G2JQ02 O75360	Q99697
PDB IDs			2L7F 2L7M 2LKX
Enriched GO Terms of Interacting Partners?		Axonemal A Tubule Inner Sheath Intermediate Filament Sperm Flagellum Sperm Motility Flagellated Sperm Motility Cilium Movement Involved In Cell Motility Cilium-dependent Cell Motility Small Protein Activating Enzyme Binding Positive Regulation Of Anoikis Protein Binding Cilium Movement Proteasome Core Complex, Beta-subunit Complex Motile Cilium	Transcription Coactivator Activity Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Regulator Complex Fungiform Papilla Formation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Hair Follicle Placode Formation Regulation Of Wnt Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Odontoblast Differentiation Positive Regulation Of Neuroepithelial Cell Differentiation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Odontoblast Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Beta-catenin-TCF Complex Maintenance Of Cell Polarity Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Epithelial To Mesenchymal Transition Positive Regulation Of Biosynthetic Process Regulation Of Neurogenesis Positive Regulation Of Transcription By RNA Polymerase II Cytoplasmic Stress Granule Negative Regulation Of Nucleobase-containing Compound Metabolic Process Odontogenesis Positive Regulation Of Macromolecule Metabolic Process Protein Binding Mesenchymal Cell Differentiation Host-mediated Perturbation Of Symbiont Process
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