PROP1 and HESX1

Number of citations of the paper that reports this interaction (PMID 11283314)
24

Data Source:
HPRD (in vivo)

		PROP1	HESX1
Gene Name		PROP paired-like homeobox 1	HESX homeobox 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus
	Molecular Function	Chromatin Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Sequence-specific DNA Binding	DNA Binding Chromatin Binding Protein Binding Protein C-terminus Binding Sequence-specific DNA Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Central Nervous System Development Dorsal/ventral Pattern Formation Cell Migration Hypothalamus Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Hypophysis Morphogenesis Canonical Wnt Signaling Pathway Somatotropin Secreting Cell Differentiation	Transcription, DNA-templated Brain Development Otic Vesicle Formation Nose Development Negative Regulation Of Transcription, DNA-templated Forebrain Morphogenesis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: HESX1 PITX2	6 interactors: KDM1A NCOR1 NPAS2 PRMT6 PROP1 TLE1
Entrez ID		5626	8820
HPRD ID		03325	03482
Ensembl ID		ENSG00000175325
Uniprot IDs		O75360	Q9UBX0
PDB IDs			2K40
Enriched GO Terms of Interacting Partners?		Subthalamic Nucleus Development Prolactin Secreting Cell Differentiation Superior Vena Cava Morphogenesis Respiratory System Development Cell Proliferation Involved In Outflow Tract Morphogenesis Left Lung Morphogenesis Pulmonary Vein Morphogenesis Subthalamus Development Embryonic Organ Morphogenesis Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Extraocular Skeletal Muscle Development Left Lung Development Pulmonary Myocardium Development Endodermal Digestive Tract Morphogenesis Forebrain Development Deltoid Tuberosity Development Somatotropin Secreting Cell Differentiation Embryonic Organ Development Positive Regulation Of Myoblast Proliferation Morphogenesis Of An Epithelium Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Hypothalamus Cell Migration Regulation Of Myoblast Proliferation Sensory Organ Development Atrial Cardiac Muscle Tissue Morphogenesis Iris Morphogenesis Embryonic Morphogenesis Tissue Morphogenesis Otic Vesicle Formation Venous Blood Vessel Morphogenesis Otic Vesicle Morphogenesis Brain Development Adenohypophysis Development Left/right Axis Specification Head Development Otic Vesicle Development Venous Blood Vessel Development Vascular Smooth Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Development Nose Development Central Nervous System Development Forebrain Morphogenesis Myoblast Fusion Organ Morphogenesis Left/right Pattern Formation Atrioventricular Valve Development Anatomical Structure Formation Involved In Morphogenesis Hypothalamus Development Epithelium Development Negative Regulation Of Transcription, DNA-templated	Diencephalon Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Central Nervous System Development Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Death Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Pituitary Gland Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Intracellular Signal Transduction Forebrain Development Circadian Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Cell Death RNA Metabolic Process Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Primitive Erythrocyte Differentiation Chromatin Modification Positive Regulation Of Metabolic Process Gene Expression Regulation Of Histone Modification Regulation Of Response To DNA Damage Stimulus Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Histone H3-R2 Methylation Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Chromatin Organization Brain Development Head Development Hypophysis Morphogenesis CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Circadian Rhythm System Development Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Chromosome Organization Nervous System Development
Tagcloud ?		abundant anterior bait cdna cloned cloning diencephalon differentiating fshbeta gland homeobox hybrid library lobe participating periods pituitary porcine pou primordium progenitor prrx1 prrx2 retina rpf1 sequence transcripts upstream yeast	affect axis cause deficiency deletions disturbances division encoding failure gh gli2 heterozygous hormone humans labile mutations numerous pericentrin pit1 pituitary pou1f1 prop1 regulators releasing responsible short stat5b stature subunit
Tagcloud (Difference) ?		abundant anterior bait cdna cloned cloning diencephalon differentiating fshbeta gland homeobox hybrid library lobe participating periods porcine pou primordium progenitor prrx1 prrx2 retina rpf1 sequence transcripts upstream yeast	affect axis cause deficiency deletions disturbances division encoding failure gh gli2 heterozygous hormone humans labile mutations numerous pericentrin pit1 pou1f1 regulators releasing responsible short stat5b stature subunit
Tagcloud (Intersection) ?		pituitary prop1