PROP1 and KRTAP19-7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PROP1	KRTAP19-7
Description		PROP paired-like homeobox 1	keratin associated protein 19-7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Cytosol Intermediate Filament
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Beta-catenin Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Central Nervous System Development Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Cell Migration Hypothalamus Cell Differentiation Pituitary Gland Development Adenohypophysis Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Gland Development Hypophysis Morphogenesis Somatotropin Secreting Cell Differentiation
Pathways			Keratinization
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Interacting Genes		54 interacting genes: ABHD11 ACTMAP ARSA BATF2 C1orf94 C6orf15 CFAP68 CIMIP2A COX6B2 CRYBA1 CYSRT1 DAZAP2 EFEMP2 FAM168A HDHD3 HESX1 HNRNPF HOXA1 INTS11 KHDC1 KRTAP13-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP6-3 KRTAP8-1 MAGED1 METTL15 METTL27 NR1D2 OLIG3 OXER1 P4HA3 PITX2 PLEKHB2 POU6F2 PSMB11 PSMB4 RNF144B RNF4 SMUG1 SPMIP6 SUMO1 TBX22 TEKT4 TEKT5 TENT5B TINAGL1 TLE5 TMEM42 TRIM42 UBE2I UFSP1 ZNF503	83 interacting genes: ANKS1A ARID5A ARMC7 ATPAF2 ATXN1L BAHD1 BHLHE40 C11orf16 CAMK2A CAMK2B CATSPER1 CCDC24 CCNK COL8A1 CYSRT1 DAB1 DAZAP2 DTX2 EVX2 FAM168A FOXD2 FOXH1 FOXI1 GLIS2 GNE GSX1 HOMER3 HOXA1 HSF4 IRX6 KPRP KRT34 KRTAP10-8 KRTAP12-3 KRTAP12-4 KRTAP26-1 KRTAP3-3 KRTAP6-3 KRTAP9-2 LONRF1 MAPK1IP1L MGAT5B MKRN3 NAF1 NEU4 NOTO NOXA1 OTX1 PATZ1 PAX7 PITX1 PITX2 PLSCR3 PLSCR4 POU2AF1 POU4F2 PROP1 PRR13 PSMB1 PSMB2 RBPMS RBPMS2 RHOXF2 RNF44 ROR2 SMN1 SMN2 SPAG8 SPMIP9 TCAP TCF7L2 TEKT5 TFAP2D TLE5 TLX3 TNIP1 TOLLIP TPRX1 VAC14 VENTX VGLL3 VPS37C ZIC1
Entrez ID		5626	337974
HPRD ID		03325	11211
Ensembl ID		ENSG00000175325	ENSG00000244362
Uniprot IDs		A0A0G2JQ02 O75360	Q3SYF9
PDB IDs
Enriched GO Terms of Interacting Partners?		Axonemal A Tubule Inner Sheath Intermediate Filament Sperm Flagellum Sperm Motility Flagellated Sperm Motility Cilium Movement Involved In Cell Motility Cilium-dependent Cell Motility Small Protein Activating Enzyme Binding Positive Regulation Of Anoikis Protein Binding Cilium Movement Proteasome Core Complex, Beta-subunit Complex Motile Cilium	Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Intermediate Filament Sequence-specific DNA Binding Keratin Filament Identical Protein Binding Nucleus Cellular Developmental Process Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Developmental Process Regionalization Myoblast Fate Commitment Regulation Of Macromolecule Biosynthetic Process Central Nervous System Development Positive Regulation Of Biosynthetic Process Pattern Specification Process Somatotropin Secreting Cell Differentiation Anatomical Structure Morphogenesis Transcription Regulator Complex Axonemal A Tubule Inner Sheath Embryonic Morphogenesis Calcium- And Calmodulin-dependent Protein Kinase Complex Positive Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Neuron Differentiation System Development Pituitary Gland Development Muscle Tissue Morphogenesis Adenohypophysis Development
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