PROP1 and TINAGL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PROP1	TINAGL1
Description		PROP paired-like homeobox 1	tubulointerstitial nephritis antigen like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Extracellular Region Extracellular Space Cytoplasm Lysosome Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Beta-catenin Binding Sequence-specific Double-stranded DNA Binding	Extracellular Matrix Structural Constituent Protein Binding Cysteine-type Peptidase Activity Laminin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Central Nervous System Development Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Cell Migration Hypothalamus Cell Differentiation Pituitary Gland Development Adenohypophysis Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Gland Development Hypophysis Morphogenesis Somatotropin Secreting Cell Differentiation	Proteolysis Endosomal Transport
Pathways
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS			Blood protein levels ( 30072576) Body mass index ( 26426971) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		54 interacting genes: ABHD11 ACTMAP ARSA BATF2 C1orf94 C6orf15 CFAP68 CIMIP2A COX6B2 CRYBA1 CYSRT1 DAZAP2 EFEMP2 FAM168A HDHD3 HESX1 HNRNPF HOXA1 INTS11 KHDC1 KRTAP13-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP6-3 KRTAP8-1 MAGED1 METTL15 METTL27 NR1D2 OLIG3 OXER1 P4HA3 PITX2 PLEKHB2 POU6F2 PSMB11 PSMB4 RNF144B RNF4 SMUG1 SPMIP6 SUMO1 TBX22 TEKT4 TEKT5 TENT5B TINAGL1 TLE5 TMEM42 TRIM42 UBE2I UFSP1 ZNF503	18 interacting genes: BAG4 CAPN1 EP300 KRTAP10-3 KRTAP12-2 KRTAP4-2 LMO4 MDFI MED31 MTDH NOTCH2NLA PITX2 PROP1 RBPMS SHBG SMAD9 TRIP13 UTP14A
Entrez ID		5626	64129
HPRD ID		03325	07122
Ensembl ID		ENSG00000175325	ENSG00000142910
Uniprot IDs		A0A0G2JQ02 O75360	F6SDV2 Q9GZM7
PDB IDs
Enriched GO Terms of Interacting Partners?		Axonemal A Tubule Inner Sheath Intermediate Filament Sperm Flagellum Sperm Motility Flagellated Sperm Motility Cilium Movement Involved In Cell Motility Cilium-dependent Cell Motility Small Protein Activating Enzyme Binding Positive Regulation Of Anoikis Protein Binding Cilium Movement Proteasome Core Complex, Beta-subunit Complex Motile Cilium	Transcription Coregulator Activity Transcription Regulator Complex Somatotropin Secreting Cell Differentiation Pre-mRNA Intronic Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Peptidyl-lysine Propionylation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Fate Commitment Swimming Positive Regulation Of RNA Metabolic Process Pattern Specification Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Lactyltransferase (CoA-dependent) Activity Negative Regulation Of RNA Metabolic Process NF-kappaB Binding Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding SMAD Protein Signal Transduction Pituitary Gland Development Superior Vena Cava Morphogenesis Subthalamic Nucleus Development Negative Regulation Of MRNA Modification Intermediate Filament Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Histone H2B Acetyltransferase Activity Negative Regulation Of RNA Biosynthetic Process Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Peptide 2-hydroxyisobutyryltransferase Activity Cell Differentiation Regulation Of Transcription By RNA Polymerase II Protein Propionyltransferase Activity Negative Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Left Lung Morphogenesis Prolactin Secreting Cell Differentiation Cell Proliferation Involved In Outflow Tract Morphogenesis Pulmonary Vein Morphogenesis
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