ADAM23 and SATB2

Data Source: HiPPIP (Novel)

		ADAM23	SATB2
Name		ADAM metallopeptidase domain 23	SATB homeobox 2
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Presynaptic Membrane Glutamatergic Synapse	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nuclear Matrix Nuclear Lumen
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding
	Biological Process	Proteolysis Cell Adhesion Central Nervous System Development Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Osteoblast Development Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Embryonic Pattern Specification Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Cartilage Development Roof Of Mouth Development
Pathways		LGI-ADAM interactions	SUMOylation of chromatin organization proteins RUNX2 regulates osteoblast differentiation
GWAS		Bipolar disorder and schizophrenia ( 22688191 ) Blood protein levels ( 30072576 ) Body mass index ( 25673413 28892062 ) Childhood body mass index ( 26604143 ) Fish- and plant-related diet ( 32066663 ) Neurological blood protein biomarker levels ( 31320639 ) Tonsillectomy ( 27182965 28928442 ) Trunk fat mass ( 28552196 ) Waist-hip ratio ( 28552196 )	Appendicular lean mass ( 33097823 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254 ) Brain cytoarchitecture ( 20308991 ) Cerebrospinal fluid immune biomarker levels ( 32066700 ) Chin dimples ( 27182965 ) Colorectal cancer or advanced adenoma ( 30510241 ) Cortical volume ( 32963231 ) FEV1 ( 30804560 ) Heel bone mineral density ( 30598549 ) Height ( 31562340 ) Insomnia ( 23728906 ) Loneliness (multivariate analysis) ( 27629369 ) Lung function (FVC) ( 30804560 ) Menarche (age at onset) ( 25231870 27182965 29773799 ) Rheumatoid arthritis ( 30891314 ) Schizophrenia ( 29483656 30285260 28991256 25056061 ) Serum alkaline phosphatase levels ( 33547301 ) Sun-seeking behavior ( 32920024 ) Type 2 diabetes ( 25760438 ) Ulcerative colitis ( 20228799 ) Waist circumference ( 23966867 )
Novel Interactors		2 novel interactors: ICOS SATB2	2 novel interactors: ABI2 ADAM23
Interacting Genes		2 interacting genes: DYRK1A PRNP	8 interacting genes: FOXP1 FOXP2 FOXP4 HDAC1 MTA2 PIAS1 POLR2J3 RAB3IL1
Entrez ID		8745	23314
HPRD ID		04752	12178
Ensembl ID		ENSG00000114948	ENSG00000119042
Uniprot IDs		E7EWD3 O75077	B3KPQ9 Q59FT3 Q9UPW6
PDB IDs		Not available	1WI3 1WIZ 2CSF
GO Terms Enriched among Interactors		Tubulin Binding Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Amyloid-beta Formation Regulation Of Amide Metabolic Process Histone H3T45 Kinase Activity Type 8 Metabotropic Glutamate Receptor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Neurofilament Splicing Factor Binding Regulation Of Heterochromatin Formation ATP-dependent Protein Binding Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance Negative Regulation Of Dendritic Spine Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Aspartic-type Endopeptidase Inhibitor Activity Intracellular Copper Ion Homeostasis Dendritic Spine Maintenance Signaling Receptor Activity Cuprous Ion Binding Regulation Of T Cell Activation Cupric Ion Binding Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Activated T Cell Proliferation Lamin Binding Type 5 Metabotropic Glutamate Receptor Binding Osteoblast Development T Cell Tolerance Induction T Follicular Helper Cell Differentiation Tau-protein Kinase Activity Negative Regulation Of MRNA Splicing, Via Spliceosome Dendrite Regulation Of Inclusion Body Assembly Inclusion Body Negative Regulation Of Interleukin-17 Production Glycosaminoglycan Binding Extrinsic Component Of Membrane Negative Regulation Of Calcium-mediated Signaling Regulation Of Lymphocyte Activation Regulation Of Cell-cell Adhesion	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Androgen Receptor Signaling Pathway NuRD Complex DNA Binding Core Promoter Sequence-specific DNA Binding Negative Regulation Of RNA Biosynthetic Process Histone Deacetylase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Fate Specification Regulation Of Muscle Cell Differentiation Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Regulation Of Androgen Receptor Signaling Pathway Transcription Corepressor Activity Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nucleosomal DNA Binding Histone Deacetylase Complex Regulation Of Cell Fate Commitment DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Biosynthetic Process Putamen Development Caudate Nucleus Development Negative Regulation Of Biosynthetic Process Negative Regulation Of Muscle Cell Differentiation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Stem Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Krueppel-associated Box Domain Binding Regulation Of Transcription By RNA Polymerase II Zonula Adherens Assembly Positive Regulation Of Interleukin-21 Production Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Protein Lysine Delactylase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Fungiform Papilla Formation Negative Regulation Of Metabolic Process Protein Decrotonylase Activity Histone Decrotonylase Activity Transcription Coregulator Activity Histone Deacetylase Binding Hair Follicle Placode Formation Zinc Ion Binding Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Smooth Muscle Cell Proliferation