ADAM23

Description		ADAM metallopeptidase domain 23
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Presynaptic Membrane Glutamatergic Synapse
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity
	Biological Process	Proteolysis Cell Adhesion Central Nervous System Development Cellular Response To Leukemia Inhibitory Factor
Pathways		LGI-ADAM interactions
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 22688191) Blood protein levels ( 30072576) Body mass index ( 25673413 28892062) Childhood body mass index ( 26604143) Fish- and plant-related diet ( 32066663) Neurological blood protein biomarker levels ( 31320639) Tonsillectomy ( 27182965 28928442) Trunk fat mass ( 28552196) Waist-hip ratio ( 28552196)
Novel Interacting Genes		2 novel interacting genes: ICOS SATB2
Interacting Genes		2 interacting genes: DYRK1A PRNP
Entrez ID		8745
HPRD ID		04752
Ensembl ID		ENSG00000114948
Uniprot IDs		E7EWD3 O75077
PDB IDs
Enriched GO Terms of Interacting Partners?		Tubulin Binding Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Amyloid-beta Formation Regulation Of Amide Metabolic Process Histone H3T45 Kinase Activity Type 8 Metabotropic Glutamate Receptor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Neurofilament Splicing Factor Binding Regulation Of Heterochromatin Formation ATP-dependent Protein Binding Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance Negative Regulation Of Dendritic Spine Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Aspartic-type Endopeptidase Inhibitor Activity Intracellular Copper Ion Homeostasis Dendritic Spine Maintenance Signaling Receptor Activity Cuprous Ion Binding Regulation Of T Cell Activation Cupric Ion Binding Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Activated T Cell Proliferation Lamin Binding Type 5 Metabotropic Glutamate Receptor Binding Osteoblast Development T Cell Tolerance Induction T Follicular Helper Cell Differentiation Tau-protein Kinase Activity Negative Regulation Of MRNA Splicing, Via Spliceosome Dendrite Regulation Of Inclusion Body Assembly Inclusion Body Negative Regulation Of Interleukin-17 Production Glycosaminoglycan Binding Extrinsic Component Of Membrane Negative Regulation Of Calcium-mediated Signaling Regulation Of Lymphocyte Activation Regulation Of Cell-cell Adhesion
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