ADAM23 and ICOS

		ADAM23	ICOS
Description		ADAM metallopeptidase domain 23	inducible T cell costimulator
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Presynaptic Membrane Glutamatergic Synapse	Extracellular Region Plasma Membrane Membrane
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Proteolysis Cell Adhesion Central Nervous System Development Cellular Response To Leukemia Inhibitory Factor	T Cell Tolerance Induction Immune Response T Cell Costimulation T Follicular Helper Cell Differentiation Cell-cell Adhesion
Pathways		LGI-ADAM interactions	Nuclear events stimulated by ALK signaling in cancer
Drugs
Diseases			Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Bipolar disorder and schizophrenia ( 22688191) Blood protein levels ( 30072576) Body mass index ( 25673413 28892062) Childhood body mass index ( 26604143) Fish- and plant-related diet ( 32066663) Neurological blood protein biomarker levels ( 31320639) Tonsillectomy ( 27182965 28928442) Trunk fat mass ( 28552196) Waist-hip ratio ( 28552196)	Alopecia areata ( 20596022 25608926) Aluminium levels ( 26025379) Body mass index ( 28892062) Celiac disease ( 20190752) Diastolic blood pressure ( 30224653) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Ulcerative colitis ( 26192919)
Interacting Genes		2 interacting genes: DYRK1A PRNP	4 interacting genes: ICOSLG NUFIP2 RC3H1 WIF1
Entrez ID		8745	29851
HPRD ID		04752	09196
Ensembl ID		ENSG00000114948	ENSG00000163600
Uniprot IDs		E7EWD3 O75077	Q53QY6 Q9Y6W8
PDB IDs			6X4G 7JOO
Enriched GO Terms of Interacting Partners?		Tubulin Binding Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Amyloid-beta Formation Regulation Of Amide Metabolic Process Histone H3T45 Kinase Activity Type 8 Metabotropic Glutamate Receptor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Neurofilament Splicing Factor Binding Regulation Of Heterochromatin Formation ATP-dependent Protein Binding Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance Negative Regulation Of Dendritic Spine Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Aspartic-type Endopeptidase Inhibitor Activity Intracellular Copper Ion Homeostasis Dendritic Spine Maintenance Signaling Receptor Activity Cuprous Ion Binding Regulation Of T Cell Activation Cupric Ion Binding Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Activated T Cell Proliferation Lamin Binding Type 5 Metabotropic Glutamate Receptor Binding Osteoblast Development T Cell Tolerance Induction T Follicular Helper Cell Differentiation Tau-protein Kinase Activity Negative Regulation Of MRNA Splicing, Via Spliceosome Dendrite Regulation Of Inclusion Body Assembly Inclusion Body Negative Regulation Of Interleukin-17 Production Glycosaminoglycan Binding Extrinsic Component Of Membrane Negative Regulation Of Calcium-mediated Signaling Regulation Of Lymphocyte Activation Regulation Of Cell-cell Adhesion	T Follicular Helper Cell Differentiation T Cell Differentiation Involved In Immune Response Regulation Of Activated T Cell Proliferation T-helper Cell Differentiation CD4-positive, Alpha-beta T Cell Differentiation Sperm DNA Decondensation Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Zonula Adherens Assembly Cytoplasmic Stress Granule CCR4-NOT Complex Binding Negative Regulation Of Germinal Center Formation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?