EIF6 and CRELD1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF6	CRELD1
Description		eukaryotic translation initiation factor 6	CRELD disulfide isomerase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Cytosol Intermediate Filament Synapse Extracellular Exosome	Membrane Extracellular Matrix Synapse Glutamatergic Synapse
	Molecular Function	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding	Protein Disulfide Isomerase Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Isomerase Activity
	Biological Process	Ribosomal Subunit Export From Nucleus Maturation Of 5.8S RRNA Maturation Of LSU-rRNA Regulation Of Glycolytic Process Translation Translational Initiation Response To Insulin MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Ribosome Biogenesis Cytosolic Ribosome Assembly Ribosomal Large Subunit Biogenesis Regulation Of Fatty Acid Biosynthetic Process Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Reactive Oxygen Species Metabolic Process	Endocardial Cushion Development Cardiac Septum Development
Pathways
Drugs		Copper
Diseases			Atrioventricular septal defect; Atrioventricular canal defect
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Fish- and plant-related diet ( 32066663) Height ( 18391951) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood protein levels ( 30072576)
Interacting Genes		41 interacting genes: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP CEP126 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FUNDC2 GIT1 HIP1 HPF1 ITGB4 LRIF1 MEOX2 MRPS31 MSRB3 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 PTEN RACK1 RPL6 SEPTIN3 TK1 UPF3B USP33 VAC14 WFS1 XRN2 ZBTB26	17 interacting genes: ATP5MF COPS6 DRD2 EEF1G EIF6 GDF9 HOXA1 HTR2C KAT5 MAP3K1 MTNR1B NUFIP2 POLA2 PTN SETDB1 SHANK3 ZNF408
Entrez ID		3692	78987
HPRD ID		04221	06206
Ensembl ID		ENSG00000242372	ENSG00000163703
Uniprot IDs		P56537	A0A669KAV0 A0A669KBB3 A0A804HJJ0 A0A804HKP7 Q96HD1
PDB IDs		6LQM 6LSR 6LSS 6LU8 7OW7 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8IDT 8IDY 8IE3 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8OHD 8OJ0 8OJ8 8RL2 9GMO
Enriched GO Terms of Interacting Partners?		Calyx Of Held Identical Protein Binding Regulation Of Proteolysis Regulation Of Translation Negative Regulation Of Gene Expression Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Viral Life Cycle Translation Anaphase-promoting Complex Binding Negative Regulation Of Cell Size Regulation Of Vesicle-mediated Transport Positive Regulation Of Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Viral Process Mitotic Nuclear Membrane Disassembly Centriolar Satellite Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Protein Binding Post-transcriptional Regulation Of Gene Expression Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Chemokine Production G Protein-coupled Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Receptor Internalization Negative Regulation Of Viral Process Double-stranded RNA Binding Membrane Disassembly Spindle Organization Nuclear Membrane Disassembly Endoplasmic Reticulum Unfolded Protein Response Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Endocytosis Antiviral Innate Immune Response Postsynaptic Density Organization Negative Regulation Of Translation Protein Disulfide Isomerase Activity Ribosome	Regulation Of Synapse Structural Plasticity Regulation Of Long-term Synaptic Potentiation Regulation Of Hormone Secretion Auditory Behavior Cognition Regulation Of Circadian Rhythm Neuromuscular Process Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Long-term Synaptic Potentiation Regulation Of System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Memory Regulation Of Behavior Mechanosensory Behavior Regulation Of Circadian Sleep/wake Cycle Regulation Of Nervous System Process Positive Regulation Of Circadian Rhythm Regulation Of Long-term Neuronal Synaptic Plasticity Ionotropic Glutamate Receptor Binding Learning Regulation Of Peptide Hormone Secretion Regulation Of Cell Development Negative Regulation Of Insulin Secretion Regulation Of Neuroblast Proliferation Regulation Of Synaptic Plasticity Positive Regulation Of Cell Development Regulation Of Multicellular Organismal Process Negative Regulation Of Peptide Secretion Semicircular Canal Formation Regulation Of Lipid Biosynthetic Process Assembly Of Large Subunit Precursor Of Preribosome Histone H2AK5 Acetyltransferase Activity Receptor Clustering Regulation Of Neuronal Synaptic Plasticity Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Neurogenesis Regulation Of Hormone Levels Ciliary Membrane Visual Behavior G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Differentiation Synapse Negative Regulation Of Sequestering Of Calcium Ion Female Gamete Generation Regulation Of Progesterone Secretion Abducens Nerve Formation Optokinetic Behavior 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
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