METAP2 and S100A4

Number of citations of the paper that reports this interaction (PMID 11994292)
12

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		METAP2	S100A4
Gene Name		methionyl aminopeptidase 2	S100 calcium binding protein A4
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Extracellular Space Nucleus Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Aminopeptidase Activity Metalloexopeptidase Activity Poly(A) RNA Binding Metal Ion Binding Metalloaminopeptidase Activity	Actin Binding Calcium Ion Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Proteolysis Phototransduction, Visible Light Rhodopsin Mediated Signaling Pathway Protein Processing Peptidyl-methionine Modification Regulation Of Rhodopsin Mediated Signaling Pathway N-terminal Protein Amino Acid Modification Protein Initiator Methionine Removal	Epithelial To Mesenchymal Transition Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction
Drugs		L-Methionine 3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium Fumagillin D-Methionine N\'-(2s,3r)-3-Amino-4-Cyclohexyl-2-Hydroxy-Butano-N-(4-Methylphenyl)Hydrazide (E)-(2r,3r,4s,5r)-3,4,5-Trihydroxy-2-Methoxy-8,8-Dimethyl-Non-6-Enoic Acid ((3s,6r)-6-Hydroxy-2-Oxo-Azepan-3-Yl)-Amide 2-Methyl-2-Propanol (2s,3r)-3-Amino-2-Hydroxy-5-(Ethylsulfanyl)Pentanoyl-((S)-(-)-(1-Naphthyl)Ethyl)Amide Ovalicin 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID N\'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID (CHLOROACETYL)CARBAMIC ACID (3R,4S,5S,5R)-5-METHOXY-4-[(2R,3R)-2-METHYL-3-(3-METHYL-2-BUTENYL)OXIRANYL]-1-OXASPIRO[2.5]OCT-6-YL ESTER
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APP CALM1 CDC42 EIF2AK2 EIF2S3 HMGA1 MAPK1 MAPK3 RAC1 S100A4	22 interactors: ACTA1 ANXA2 BAG6 MDM2 METAP2 MYH10 MYH2 MYH4 MYH9 NOV PPFIBP1 S100A1 S100B S100P SEPT2 SEPT6 SEPT7 SMAD3 TP53 TPM2 TPM3 UNC119
Entrez ID		10988	6275
HPRD ID		03522	15914
Ensembl ID		ENSG00000111142	ENSG00000196154
Uniprot IDs		B4DUX5 F8VQZ7 G3XA91 P50579	P26447
PDB IDs		1B59 1B6A 1BN5 1BOA 1KQ0 1KQ9 1QZY 1R58 1R5G 1R5H 1YW7 1YW8 1YW9 2ADU 2EA2 2EA4 2GA2 2OAZ	1M31 2LNK 2Q91 3C1V 3CGA 3KO0 3M0W 3ZWH 4ETO 4HSZ
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Innate Immune Response Blood Coagulation Hemostasis Platelet Activation Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Regulation Of Body Fluid Levels Fc Receptor Signaling Pathway Response To External Stimulus Wound Healing Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Wounding Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Phosphorus Metabolic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Biosynthetic Process Immune Response-regulating Signaling Pathway Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cellular Metabolic Process Regulation Of Golgi Inheritance Regulation Of Cellular Ketone Metabolic Process Axonogenesis Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signal Transduction Caveolin-mediated Endocytosis Cell Morphogenesis Viral Process Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Axon Development	Actin Filament-based Movement Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Cell Cycle Process Cytokinesis Cell Cycle Actin Filament-based Process Muscle Contraction Cell Division Movement Of Cell Or Subcellular Component Muscle System Process Regulation Of Cell Shape Plasma Membrane Repair Response To External Stimulus Anatomical Structure Morphogenesis Cellular Component Assembly Anatomical Structure Formation Involved In Morphogenesis Mitotic Cell Cycle Process Regulation Of Cellular Component Organization Response To Abiotic Stimulus Mitotic Cell Cycle Regulation Of Cell Morphogenesis Cellular Response To Light Stimulus Cell Projection Morphogenesis Membrane Organization Cell Part Morphogenesis Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cell Development Response To Hypoxia Cellular Response To Oxygen Levels Actomyosin Structure Organization Signal Transduction By P53 Class Mediator Wound Healing Response To Light Stimulus Response To Stimulus Regulation Of Protein Stability Cellular Response To Radiation Cell Morphogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To Wounding Cell Differentiation Anatomical Structure Development Immune System Process Cellular Response To Stimulus System Development Cell Projection Organization Positive Regulation Of Transport Cell Adhesion
Tagcloud ?		aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h	aldh1 anatomically area areas biomarkers cadherin cd44 central detailed egfr expressions fgfr1 heterogeneous immunohistochemical lymph metastatic molecules node nodes peripheral precise prediction recurrence relationships shorter sox2 squamous staining vegfr2
Tagcloud (Difference) ?		aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h	aldh1 anatomically area areas biomarkers cadherin cd44 central detailed egfr expressions fgfr1 heterogeneous immunohistochemical lymph metastatic molecules node nodes peripheral precise prediction recurrence relationships shorter sox2 squamous staining vegfr2
Tagcloud (Intersection) ?