MAP2K3 and ARAF

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MAP2K3	ARAF
Description		mitogen-activated protein kinase kinase 3	A-Raf proto-oncogene, serine/threonine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Regulation Of Cytokine Production Response To Ischemia Inflammatory Response Signal Transduction Heart Development Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Hippo Signaling Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA-templated Transcription Protein Maturation Cardiac Muscle Contraction Pyroptotic Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To UV-B Cellular Response To Sorbitol Cellular Senescence Regulation Of Intracellular Signal Transduction NLRP1 Inflammasome Complex Assembly	MAPK Cascade Signal Transduction Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Protein Modification Process Negative Regulation Of Apoptotic Process
Pathways		Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs		Fostamatinib Pimasertib	ATP
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062)
Interacting Genes		53 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP3K2 MAP3K3 MAP3K4 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53	57 interacting genes: AGTRAP AKT1 ASS1 BAD BECN1 CCND2 CDK4 CDK6 CDKN2B CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 EPHA2 FGFR4 GLIS2 GNA12 HRAS IRAK2 IRF7 KLHL12 LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MLH1 MYC MYO18A NELFCD NF2 NRAS NUDT14 PBK PDGFRB PIK3CA PIK3R1 PKM PRPF6 RABGGTB RASSF1 RGS12 RRAS RRAS2 SFN STK11 TEKT4P2 TESK1 TIMM44 TIRAP TP53 TSC1 WNK1 YWHAG
Entrez ID		5606	369
HPRD ID		03816	02405
Ensembl ID		ENSG00000034152	ENSG00000078061
Uniprot IDs		P46734 Q6FI23	A0A024R178 P10398 Q96II5
PDB IDs			1WXM 2MSE 9AXM
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Kinase Activity Regulation Of Cell Cycle MAP Kinase Kinase Kinase Activity Regulation Of Intracellular Signal Transduction Animal Organ Development Developmental Process Regulation Of Cell Population Proliferation Regulation Of Cellular Component Organization Signal Transduction Regulation Of Cell Cycle Process Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Signaling Regulation Of Cell Communication Transferase Activity Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Cellular Developmental Process Response To Growth Factor Cell Differentiation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition ATP Binding Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Component Organization Cytosol Positive Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Metabolic Process Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Differentiation Regulation Of Growth Regulation Of Apoptotic Process	Intracellular Signal Transduction Signal Transduction Nucleotide Binding Intracellular Signaling Cassette ATP Binding Regulation Of Intracellular Signal Transduction Protein Kinase Activity Kinase Activity Protein Tyrosine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Protein Serine Kinase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Cellular Component Organization MAP Kinase Kinase Activity Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction MAPK Cascade Cell Surface Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Metabolic Process Cellular Response To Stress Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Motility Regulation Of Protein Localization Regulation Of Catalytic Activity Regulation Of Cell Cycle Regulation Of Cell Adhesion Regulation Of Epithelial Cell Proliferation Regulation Of Locomotion Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Protein Localization To Membrane Apoptotic Signaling Pathway Cellular Response To Radiation Regulation Of Cellular Localization Negative Regulation Of Macroautophagy Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Positive Regulation Of Protein Localization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Primary Metabolic Process
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