MAP2K3 and CDKN2C

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MAP2K3	CDKN2C
Description		mitogen-activated protein kinase kinase 3	cyclin dependent kinase inhibitor 2C
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Serine Kinase Activity	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding
	Biological Process	MAPK Cascade Regulation Of Cytokine Production Response To Ischemia Inflammatory Response Signal Transduction Heart Development Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Hippo Signaling Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA-templated Transcription Protein Maturation Cardiac Muscle Contraction Pyroptotic Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To UV-B Cellular Response To Sorbitol Cellular Senescence Regulation Of Intracellular Signal Transduction NLRP1 Inflammasome Complex Assembly	Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Oligodendrocyte Differentiation Stem Cell Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Stem Cell Proliferation
Pathways		Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1
Drugs		Fostamatinib Pimasertib
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062)	Atrial fibrillation ( 29290336) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 33713608 31562340) Hip circumference adjusted for BMI ( 34021172) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Ischemic stroke (large artery atherosclerosis) ( 26732560) Male-pattern baldness ( 28196072) Pulse pressure ( 30578418) QRS complex (12-leadsum) ( 27659466) QRS duration ( 27577874 21076409 27659466) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Thyroid stimulating hormone levels ( 32769997) Ventricular ectopy ( 29618737) Ventricular ectopy or supraventricular ectopy (pleiotropy) ( 29618737)
Interacting Genes		53 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP3K2 MAP3K3 MAP3K4 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53	59 interacting genes: AHCYL1 AKT1 ANGPTL4 APLP1 ARNT ATM ATR CCDC90B CCND2 CCNE1 CDK4 CDK6 CDKN2A CDKN2B COPS6 CRX CTDSP1 DRAP1 EPHA2 ERBB2 FGFR4 GDF9 GOPC GREB1 GRM1 KRT31 LATS2 LNX2 LRIF1 LY96 MAP2K3 MAP2K5 MAPK10 MAPK8 MTA3 MYC NAGK NAT2 NF2 NIF3L1 PBX4 PDGFRA PLEKHG4 POU6F2 PPP2CA RAF1 RBM48 REL SCGB2A2 SNU13 SORBS3 ST14 STK11 TCF12 TCF4 TLE1 TP53 UBC UNC119
Entrez ID		5606	1031
HPRD ID		03816	04534
Ensembl ID		ENSG00000034152	ENSG00000123080
Uniprot IDs		P46734 Q6FI23	P42773 Q6ICV4
PDB IDs			1BU9 1G3N 1IHB 1MX2 1MX4 1MX6
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Kinase Activity Regulation Of Cell Cycle MAP Kinase Kinase Kinase Activity Regulation Of Intracellular Signal Transduction Animal Organ Development Developmental Process Regulation Of Cell Population Proliferation Regulation Of Cellular Component Organization Signal Transduction Regulation Of Cell Cycle Process Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Signaling Regulation Of Cell Communication Transferase Activity Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Cellular Developmental Process Response To Growth Factor Cell Differentiation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition ATP Binding Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Component Organization Cytosol Positive Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Metabolic Process Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Differentiation Regulation Of Growth Regulation Of Apoptotic Process	Kinase Activity Protein Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Cell Cycle Phase Transition Cellular Senescence Phosphorylation Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Protein Phosphorylation Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Regulation Of Primary Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Signal Transduction MAPK Cascade Regulation Of Cell Cycle Process Replicative Senescence Positive Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Macromolecule Metabolic Process Response To Radiation Regulation Of Cell Population Proliferation G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Cell Communication Response To UV Positive Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Light Stimulus Cellular Response To Radiation Regulation Of Signaling Regulation Of Cell Communication ATP Binding Regulation Of Catalytic Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition
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