MAP2K3 and MAP3K3

Number of citations of the paper that reports this interaction (PubMedID 9162092)
0

Data Source:
BioGRID (enzymatic study)

		MAP2K3	MAP3K3
Description		mitogen-activated protein kinase kinase 3	mitogen-activated protein kinase kinase kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Regulation Of Cytokine Production Response To Ischemia Inflammatory Response Signal Transduction Heart Development Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Hippo Signaling Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA-templated Transcription Protein Maturation Cardiac Muscle Contraction Pyroptotic Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To UV-B Cellular Response To Sorbitol Cellular Senescence Regulation Of Intracellular Signal Transduction NLRP1 Inflammasome Complex Assembly	MAPK Cascade Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Autophosphorylation Positive Regulation Of P38MAPK Cascade
Pathways		Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation	Interleukin-1 signaling
Drugs		Fostamatinib Pimasertib	Fostamatinib
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Height ( 18391951 21998595 22021425 25429064 28552196) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		53 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP3K2 MAP3K3 MAP3K4 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53	44 interacting genes: BIRC2 BRCA1 CDC37 COPS5 EGFR GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB LATS1 MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 TOM1L1 TRAF6 TRAF7 VWF WNK1 XIAP YAP1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16
Entrez ID		5606	4215
HPRD ID		03816	03965
Ensembl ID		ENSG00000034152	ENSG00000198909
Uniprot IDs		P46734 Q6FI23	J3KRN4 J3QRB6 Q96HN9 Q99759
PDB IDs			2C60 2JRH 2O2V 2PPH 4Y5O 4YL6
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Kinase Activity Regulation Of Cell Cycle MAP Kinase Kinase Kinase Activity Regulation Of Intracellular Signal Transduction Animal Organ Development Developmental Process Regulation Of Cell Population Proliferation Regulation Of Cellular Component Organization Signal Transduction Regulation Of Cell Cycle Process Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Signaling Regulation Of Cell Communication Transferase Activity Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Cellular Developmental Process Response To Growth Factor Cell Differentiation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition ATP Binding Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Component Organization Cytosol Positive Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Metabolic Process Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Differentiation Regulation Of Growth Regulation Of Apoptotic Process	Intracellular Signal Transduction Intracellular Signaling Cassette MAPK Cascade Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Cytosol Positive Regulation Of Metabolic Process Canonical NF-kappaB Signal Transduction Regulation Of Primary Metabolic Process Signal Transduction Identical Protein Binding Negative Regulation Of Signal Transduction Cytoplasm Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Developmental Process Protein Serine Kinase Activity Positive Regulation Of Protein Metabolic Process Protein Polyubiquitination Regulation Of Macromolecule Metabolic Process Transferase Activity Protein Domain Specific Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein-containing Complex Positive Regulation Of Biosynthetic Process Phosphoserine Residue Binding Protein Modification Process Response To Tumor Necrosis Factor Protein Kinase Binding Regulation Of Metabolic Process Kinase Activity Negative Regulation Of Intracellular Signal Transduction Enzyme Binding Fc-epsilon Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Regulation Of Apoptotic Process Stress-activated Protein Kinase Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Cytokine Stimulus
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