MAP2K3 and MAP3K3

Number of citations of the paper that reports this interaction (PMID 9162092)
18

Data Source:
BioGRID (enzymatic study)

		MAP2K3	MAP3K3
Gene Name		mitogen-activated protein kinase kinase 3	mitogen-activated protein kinase kinase kinase 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Membrane	Intracellular Cytosol
	Molecular Function	Receptor Signaling Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	Protein Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response Signal Transduction Pathogenesis Peptidyl-tyrosine Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Cytokine Biosynthetic Process Innate Immune Response Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Stress-activated MAPK Cascade Cardiac Muscle Contraction	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Positive Regulation Of P38MAPK Cascade
Pathways		MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence MyD88-independent cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Innate Immune System	Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
Drugs
Diseases
GWAS			Height ( 21998595 22021425 18391951)
Protein-Protein Interactions		20 interactors: ALDOC APP ARRB1 DCTN1 DYRK1B ELK1 LRRK2 MAP3K2 MAP3K3 MAP3K4 MAPK12 MAPK14 MAPK3 MAPK8IP2 PLCB2 RPL13 SMAD7 TAOK1 TAOK2 TINF2	44 interactors: BIRC2 BRCA1 CDC37 COPS5 GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K2 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 SQSTM1 TOM1L1 TRAF6 TRAF7 UBC VWF WNK1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16
Entrez ID		5606	4215
HPRD ID		03816	03965
Ensembl ID		ENSG00000034152	ENSG00000198909
Uniprot IDs		P46734 Q6FI23	J3KRN4 J3QRB6 Q99759
PDB IDs			2C60 2JRH 2O2V 2PPH
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Activation Of MAPKK Activity Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Phosphate-containing Compound Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Phosphorylation Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Activation Of Protein Kinase Activity Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Response To Stress Cellular Metabolic Process Cellular Protein Metabolic Process Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Metabolic Process Regulation Of MAP Kinase Activity Cellular Response To Stress Cellular Protein Modification Process Signaling Regulation Of JNK Cascade Cell Communication	Positive Regulation Of Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Programmed Cell Death Cell Death Positive Regulation Of Protein Serine/threonine Kinase Activity Death Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Cell Death Activation Of MAPK Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response JNK Cascade Signaling Response To Stress Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Cell Communication Signal Transduction By Phosphorylation Positive Regulation Of MAP Kinase Activity Regulation Of MAP Kinase Activity
Tagcloud ?		alternate ask biogenesis cascades cytochrome discovered dissociation generating glycolysis hypoxic induces mapkkk metallochaperone mitogen oxidase oxphos possess prevents redox ros sco2 switches switching thioredoxin thr tigar trx xenografts	11ra affymetrix cacna1s classify correctly dataset erosive favors flammatory ikbkb nucleoporin partitioning paxgene pbc pbcs proin psa psoriatic psors1 psors2 recursive s100a12 s100a8 shp1 sigirr tcf7 thioredoxin tubes u133a
Tagcloud (Difference) ?		alternate ask biogenesis cascades cytochrome discovered dissociation generating glycolysis hypoxic induces mapkkk metallochaperone mitogen oxidase oxphos possess prevents redox ros sco2 switches switching thr tigar trx xenografts	11ra affymetrix cacna1s classify correctly dataset erosive favors flammatory ikbkb nucleoporin partitioning paxgene pbc pbcs proin psa psoriatic psors1 psors2 recursive s100a12 s100a8 shp1 sigirr tcf7 tubes u133a
Tagcloud (Intersection) ?		thioredoxin