MAPK13 and MAP2K6

Number of citations of the paper that reports this interaction (PubMedID 9218798)
27

Data Source:
HPRD (in vitro)

		MAPK13	MAP2K6
Description		mitogen-activated protein kinase 13	mitogen-activated protein kinase kinase 6
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Response To Osmotic Stress Positive Regulation Of Interleukin-6 Production Cellular Response To Stress Cellular Response To UV Intracellular Signal Transduction Positive Regulation Of Inflammatory Response Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Sorbitol Cellular Response To Anisomycin Cellular Response To Sodium Arsenite	MAPK Cascade Osteoblast Differentiation Apoptotic Process Signal Transduction Stress-activated Protein Kinase Signaling Cascade Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway P38MAPK Cascade Signal Transduction In Response To DNA Damage Positive Regulation Of MAPK Cascade Stress-activated MAPK Cascade Protein Maturation Regulation Of Cell Cycle Cardiac Muscle Contraction Bone Development Pyroptotic Inflammatory Response Cellular Response To UV-B Cellular Senescence Negative Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intracellular Signal Transduction NLRP1 Inflammasome Complex Assembly
Pathways		NOD1/2 Signaling Pathway p38MAPK events VEGFA-VEGFR2 Pathway	NOD1/2 Signaling Pathway Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation Myogenesis PI5P Regulates TP53 Acetylation Interleukin-1 signaling PKR-mediated signaling
Drugs		Minocycline KC706 Fostamatinib	Fostamatinib Pimasertib
Diseases
GWAS		Birth weight ( 31043758) Blood protein levels ( 30072576) Offspring birth weight ( 31043758)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Optic disc size ( 31809533) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Waist-hip ratio ( 28552196)
Interacting Genes		17 interacting genes: AKIP1 ANKLE2 APP ATF2 BTRC EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4 SQSTM1	39 interacting genes: AKT1 BECN1 BRAF CCND2 CDKN2B DCTN1 EIF2AK2 EPHA2 FBXO7 FGFR4 GLIS2 HGF HRAS LRRK2 MAP2K4 MAP2K5 MAP3K20 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK12 MAPK13 MAPK14 MAPKAPK2 MLH1 NFE2L2 PICK1 PKN1 PLCB2 RAF1 RASSF1 RELA SMAD7 STAT4 STK11 TAOK2 TLR3 TRAF6
Entrez ID		5603	5608
HPRD ID		09113	03155
Ensembl ID		ENSG00000156711	ENSG00000108984
Uniprot IDs		A0A024RD04 O15264	A8K3Y2 P52564
PDB IDs		3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO 8X23	2Y8O 3ENM 3FME 3VN9 5ETF 8A8M 8P7J 8PM3
Enriched GO Terms of Interacting Partners?		MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction MAP Kinase Kinase Activity P38MAPK Cascade Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Response To Nerve Growth Factor Response To Growth Factor Main Axon Cellular Response To Nerve Growth Factor Stimulus Calcium-dependent Protein Serine/threonine Kinase Activity Brainstem Development Regulation Of Transforming Growth Factor Beta2 Production Cellular Response To Brain-derived Neurotrophic Factor Stimulus Protein Serine/threonine Kinase Activity Calmodulin Binding Protein-containing Complex Adult Locomotory Behavior Developmental Process Regulation Of Cell Communication Signal Transduction Negative Regulation Of Ferroptosis Regulation Of Ferroptosis Protein Kinase Activity Apolipoprotein Binding Identical Protein Binding Astrocyte Activation Apoptotic Process Response To Lead Ion Regulation Of Superoxide Anion Generation Regulation Of Signal Transduction Programmed Cell Death Cell Death Nucleus Positive Regulation Of Superoxide Anion Generation Immune System Process Calcium/calmodulin-dependent Protein Kinase Activity Mitogen-activated Protein Kinase Binding Positive Regulation Of Long-term Synaptic Potentiation Kinase Activity Regulation Of Programmed Cell Death Protein Serine Kinase Activity Amyloid Fibril Formation Regulation Of Superoxide Metabolic Process Protein Phosphatase 2A Binding Immune Response-activating Signaling Pathway Response To Oxidative Stress Central Nervous System Development	MAPK Cascade Intracellular Signal Transduction Protein Serine Kinase Activity Protein Kinase Activity Intracellular Signaling Cassette Protein Serine/threonine Kinase Activity Kinase Activity MAP Kinase Kinase Kinase Activity Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stress ATP Binding Regulation Of Signal Transduction Response To Stress Regulation Of Cell Communication Regulation Of Signaling Stress-activated MAPK Cascade Nucleotide Binding P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Transferase Activity Positive Regulation Of Macromolecule Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of MAPK Cascade Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Response To Cytokine Protein Phosphorylation Response To Peptide Positive Regulation Of MAPK Cascade Phosphorylation JNK Cascade Immune Response-regulating Signaling Pathway Response To Growth Factor Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling MAP Kinase Activity Regulation Of Immune System Process Immune Response-activating Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process Cell Death
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