MAPK13 and MAP3K4

Number of citations of the paper that reports this interaction (PubMedID 9841871)
44

Data Source:
HPRD (in vivo, in vitro)

		MAPK13	MAP3K4
Description		mitogen-activated protein kinase 13	mitogen-activated protein kinase kinase kinase 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Response To Osmotic Stress Positive Regulation Of Interleukin-6 Production Cellular Response To Stress Cellular Response To UV Intracellular Signal Transduction Positive Regulation Of Inflammatory Response Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Sorbitol Cellular Response To Anisomycin Cellular Response To Sodium Arsenite	MAPK Cascade Placenta Development Response To UV-C Regulation Of Gene Expression Male Germ-line Sex Determination Positive Regulation Of Telomere Maintenance Intracellular Signal Transduction P38MAPK Cascade Positive Regulation Of JUN Kinase Activity Chorionic Trophoblast Cell Differentiation Positive Regulation Of P38MAPK Cascade
Pathways		NOD1/2 Signaling Pathway p38MAPK events VEGFA-VEGFR2 Pathway
Drugs		Minocycline KC706 Fostamatinib	Fostamatinib
Diseases
GWAS		Birth weight ( 31043758) Blood protein levels ( 30072576) Offspring birth weight ( 31043758)	Aging ( 22773346) Cognitive decline rate in late mild cognitive impairment ( 26252872) Lipoprotein (a) levels ( 26377243) Ovarian disease with few adhesions ( 28333195)
Interacting Genes		17 interacting genes: AKIP1 ANKLE2 APP ATF2 BTRC EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4 SQSTM1	26 interacting genes: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MFHAS1 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ
Entrez ID		5603	4216
HPRD ID		09113	03886
Ensembl ID		ENSG00000156711	ENSG00000085511
Uniprot IDs		A0A024RD04 O15264	F5H538 J3KNB8 Q9P1M2 Q9Y6R4
PDB IDs		3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO 8X23
Enriched GO Terms of Interacting Partners?		MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction MAP Kinase Kinase Activity P38MAPK Cascade Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Response To Nerve Growth Factor Response To Growth Factor Main Axon Cellular Response To Nerve Growth Factor Stimulus Calcium-dependent Protein Serine/threonine Kinase Activity Brainstem Development Regulation Of Transforming Growth Factor Beta2 Production Cellular Response To Brain-derived Neurotrophic Factor Stimulus Protein Serine/threonine Kinase Activity Calmodulin Binding Protein-containing Complex Adult Locomotory Behavior Developmental Process Regulation Of Cell Communication Signal Transduction Negative Regulation Of Ferroptosis Regulation Of Ferroptosis Protein Kinase Activity Apolipoprotein Binding Identical Protein Binding Astrocyte Activation Apoptotic Process Response To Lead Ion Regulation Of Superoxide Anion Generation Regulation Of Signal Transduction Programmed Cell Death Cell Death Nucleus Positive Regulation Of Superoxide Anion Generation Immune System Process Calcium/calmodulin-dependent Protein Kinase Activity Mitogen-activated Protein Kinase Binding Positive Regulation Of Long-term Synaptic Potentiation Kinase Activity Regulation Of Programmed Cell Death Protein Serine Kinase Activity Amyloid Fibril Formation Regulation Of Superoxide Metabolic Process Protein Phosphatase 2A Binding Immune Response-activating Signaling Pathway Response To Oxidative Stress Central Nervous System Development	Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Protein Kinase Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction MAP Kinase Kinase Activity Regulation Of JNK Cascade Signal Transduction Protein Kinase Activity Intracellular Signaling Cassette Regulation Of Cell Communication Kinase Activity Protein Tyrosine Kinase Activity Cytoplasm Protein Serine/threonine Kinase Activity Apoptotic Process Cellular Senescence Protein Serine Kinase Activity Nucleotide Binding MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Programmed Cell Death Cell Death Positive Regulation Of P38MAPK Cascade Cytosol Cell Surface Receptor Signaling Pathway Thioesterase Binding ATP Binding Regulation Of P38MAPK Cascade Regulation Of Organelle Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Modification Process Developmental Process Cellular Response To Sorbitol JUN Kinase Kinase Activity Regulation Of Cell Cycle Response To Stress Transferase Activity Regulation Of Protein Modification Process Regulation Of ERK1 And ERK2 Cascade Cellular Developmental Process Cytoskeleton Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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