MAPK13 and ATF2

Number of citations of the paper that reports this interaction (PMID 9207191)
60

Data Source:
HPRD (in vitro)

		MAPK13	ATF2
Gene Name		mitogen-activated protein kinase 13	activating transcription factor 2
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Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Site Of Double-strand Break
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding CAMP Response Element Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	MAPK Cascade Transcription, DNA-templated Regulation Of Transcription, DNA-templated Response To Stress Response To Osmotic Stress Cell Cycle Ras Protein Signal Transduction Peptidyl-serine Phosphorylation Positive Regulation Of Interleukin-6 Production Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Inflammatory Response	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Outflow Tract Morphogenesis Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Response To Osmotic Stress Cellular Response To DNA Damage Stimulus Histone Acetylation Intra-S DNA Damage Checkpoint Positive Regulation Of Transforming Growth Factor Beta2 Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Adipose Tissue Development Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways		Signalling to ERKs Signalling by NGF DSCAM interactions Signaling by VEGF Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Signalling to RAS p38MAPK events NGF signalling via TRKA from the plasma membrane VEGFA-VEGFR2 Pathway Innate Immune System	Organelle biogenesis and maintenance Toll Like Receptor 7/8 (TLR7/8) Cascade HATs acetylate histones Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Chromatin organization TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade MyD88-independent cascade Mitochondrial biogenesis Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Chromatin modifying enzymes Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: AKIP1 ANKLE2 APP ATF2 EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4	55 interactors: APP AR ATF3 ATF4 ATF7 BACH1 BATF BATF3 CCDC6 CCND1 CEBPA CEBPB CEBPG CREB5 CSNK2A1 CSNK2A2 DDIT3 EDF1 ETS1 EXOSC8 FOS FOSL1 GTF2F2 H2AFY HIST2H2BE HMGA1 IRF2BP1 JDP2 JUN KIFC3 MAPK1 MAPK10 MAPK11 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK5 MLH1 NBN NCOA6 PML PRKCE RB1 RPS6KA5 RUVBL2 SMAD3 SMAD4 SRA1 SUMO1 THRB UBE2I UTF1 XPO1 YY1
Entrez ID		5603	1386
HPRD ID		09113	00443
Ensembl ID		ENSG00000156711	ENSG00000115966
Uniprot IDs		O15264	A4D7V5 P15336
PDB IDs		3COI 4EXU 4EYJ 4EYM	1BHI 1T2K 4H36
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Adult Locomotory Behavior Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Activation Of MAPK Activity Regulation Of Protein Phosphorylation Adult Behavior Toll-like Receptor 5 Signaling Pathway Developmental Process Toll-like Receptor 10 Signaling Pathway Phosphorylation Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Response To Stress Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of MAP Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta2 Production MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Protein Modification Process Locomotory Behavior MyD88-dependent Toll-like Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Toll-like Receptor 4 Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Toll-like Receptor Signaling Pathway Response To Organic Substance Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Signaling Positive Regulation Of Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cell Communication Regulation Of Kinase Activity	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process RNA Metabolic Process Gene Expression Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Biosynthetic Process Positive Regulation Of Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Response To External Stimulus Negative Regulation Of Gene Expression Toll-like Receptor 3 Signaling Pathway
Tagcloud ?		alpha3 alpha3beta bap calcification calcifying ccl22 cd14 cd16 cd45 chi3l1 chit1 chitinase diaphyseal distinguished drilled femurs freshly fulfill gpnmb hole implanted ll monocytes monoosteophil monoosteophils osteoactivin osteopontin p38mapkdelta spp1	assayed atp compete competes diphosphorylated enzyme equal equally gly gst homogeneously ic50 inactive km monophosphorylated p38 preparations pyridinylimidazole pyridinylimidazoles s2 sb202190 sb203580 thr threonine transducing tritiated tyr ubiquitous unphosphorylated
Tagcloud (Difference) ?		alpha3 alpha3beta bap calcification calcifying ccl22 cd14 cd16 cd45 chi3l1 chit1 chitinase diaphyseal distinguished drilled femurs freshly fulfill gpnmb hole implanted ll monocytes monoosteophil monoosteophils osteoactivin osteopontin p38mapkdelta spp1	assayed atp compete competes diphosphorylated enzyme equal equally gly gst homogeneously ic50 inactive km monophosphorylated p38 preparations pyridinylimidazole pyridinylimidazoles s2 sb202190 sb203580 thr threonine transducing tritiated tyr ubiquitous unphosphorylated
Tagcloud (Intersection) ?