MAPK13 and EEF2K

Number of citations of the paper that reports this interaction (PubMedID 12171600)
25

Data Source:
HPRD (in vivo, in vitro)

		MAPK13	EEF2K
Description		mitogen-activated protein kinase 13	eukaryotic elongation factor 2 kinase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Cytosol Postsynaptic Density Dendritic Spine Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Elongation Factor-2 Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding Translation Factor Activity, RNA Binding Kinase Activity Transferase Activity
	Biological Process	MAPK Cascade Response To Osmotic Stress Positive Regulation Of Interleukin-6 Production Cellular Response To Stress Cellular Response To UV Intracellular Signal Transduction Positive Regulation Of Inflammatory Response Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Sorbitol Cellular Response To Anisomycin Cellular Response To Sodium Arsenite	Response To Ischemia Translational Elongation Myosin II Filament Disassembly Cellular Response To Insulin Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Protein Autophosphorylation Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Anoxia Regulation Of Translation At Postsynapse Cellular Response To Brain-derived Neurotrophic Factor Stimulus Response To Prolactin
Pathways		NOD1/2 Signaling Pathway p38MAPK events VEGFA-VEGFR2 Pathway	mTORC1-mediated signalling
Drugs		Minocycline KC706 Fostamatinib
Diseases
GWAS		Birth weight ( 31043758) Blood protein levels ( 30072576) Offspring birth weight ( 31043758)	Heel bone mineral density ( 30598549)
Interacting Genes		17 interacting genes: AKIP1 ANKLE2 APP ATF2 BTRC EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4 SQSTM1	17 interacting genes: CDK1 EEF2 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 PRKAA1 PRKAA2 PRKACA RPS6KA1 RPS6KB1 RPS6KB2
Entrez ID		5603	29904
HPRD ID		09113	07369
Ensembl ID		ENSG00000156711	ENSG00000103319
Uniprot IDs		A0A024RD04 O15264	A0AAG2TFE4 O00418
PDB IDs		3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO 8X23	5J8H 5KS5 6NX4 7SHQ 8FNY 8FO6 8GM4 8GM5
Enriched GO Terms of Interacting Partners?		MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction MAP Kinase Kinase Activity P38MAPK Cascade Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Response To Nerve Growth Factor Response To Growth Factor Main Axon Cellular Response To Nerve Growth Factor Stimulus Calcium-dependent Protein Serine/threonine Kinase Activity Brainstem Development Regulation Of Transforming Growth Factor Beta2 Production Cellular Response To Brain-derived Neurotrophic Factor Stimulus Protein Serine/threonine Kinase Activity Calmodulin Binding Protein-containing Complex Adult Locomotory Behavior Developmental Process Regulation Of Cell Communication Signal Transduction Negative Regulation Of Ferroptosis Regulation Of Ferroptosis Protein Kinase Activity Apolipoprotein Binding Identical Protein Binding Astrocyte Activation Apoptotic Process Response To Lead Ion Regulation Of Superoxide Anion Generation Regulation Of Signal Transduction Programmed Cell Death Cell Death Nucleus Positive Regulation Of Superoxide Anion Generation Immune System Process Calcium/calmodulin-dependent Protein Kinase Activity Mitogen-activated Protein Kinase Binding Positive Regulation Of Long-term Synaptic Potentiation Kinase Activity Regulation Of Programmed Cell Death Protein Serine Kinase Activity Amyloid Fibril Formation Regulation Of Superoxide Metabolic Process Protein Phosphatase 2A Binding Immune Response-activating Signaling Pathway Response To Oxidative Stress Central Nervous System Development	Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Nucleotide Binding ATP Binding Transferase Activity Intracellular Signal Transduction MAP Kinase Activity MAPK Cascade Intracellular Signaling Cassette Post-transcriptional Regulation Of Gene Expression TORC1 Signaling Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Signal Transduction Positive Regulation Of Metabolic Process Protein Localization To Lipid Droplet Cellular Senescence Regulation Of TOR Signaling Stress-activated MAPK Cascade Response To Reactive Oxygen Species Stress-activated Protein Kinase Signaling Cascade Calcium-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Nucleoplasm Response To Oxidative Stress Cellular Response To Oxidative Stress Cellular Response To Oxygen-containing Compound Phosphorylation Nucleus Cellular Response To Reactive Oxygen Species Regulation Of Circadian Rhythm Regulation Of Translation Cytosol Protein Metabolic Process Positive Regulation Of Translational Initiation Nucleotide-activated Protein Kinase Complex Cellular Response To Chemical Stress Response To Nutrient Levels Cytoplasm Regulation Of Gene Expression Response To Stress Regulation Of Protein Metabolic Process
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