MAPK13 and MAPKAPK5

Number of citations of the paper that reports this interaction (PubMedID 9628874)
68

Data Source:
HPRD (in vitro, in vivo)

		MAPK13	MAPKAPK5
Description		mitogen-activated protein kinase 13	MAPK activated protein kinase 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Response To Osmotic Stress Positive Regulation Of Interleukin-6 Production Cellular Response To Stress Cellular Response To UV Intracellular Signal Transduction Positive Regulation Of Inflammatory Response Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Sorbitol Cellular Response To Anisomycin Cellular Response To Sodium Arsenite	MAPK Cascade Regulation Of Translation Signal Transduction Ras Protein Signal Transduction Negative Regulation Of TOR Signaling Positive Regulation Of Telomere Maintenance Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Dendritic Spine Development Cellular Senescence Stress-induced Premature Senescence Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intracellular Signal Transduction
Pathways		NOD1/2 Signaling Pathway p38MAPK events VEGFA-VEGFR2 Pathway	Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation
Drugs		Minocycline KC706 Fostamatinib	Fostamatinib
Diseases
GWAS		Birth weight ( 31043758) Blood protein levels ( 30072576) Offspring birth weight ( 31043758)	Adult body size ( 32376654) Body mass index ( 26426971) Coffee consumption ( 29367735) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean spheric corpuscular volume ( 32888494) Psoriasis ( 28537254) Spleen volume ( 34128465) Tea consumption ( 33080986)
Interacting Genes		17 interacting genes: AKIP1 ANKLE2 APP ATF2 BTRC EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4 SQSTM1	32 interacting genes: ATF2 CDCA8 EEF2K EIF4E EIF4EBP1 GYS1 HMGB1 HSPB1 HSPB2 JUN LSR MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK4 MAPK6 MAPK9 MBP MYH11 PARK7 PLA2G4A RPL13 SNCA SRPK1 SRPK2 TAB1 TP53 YAP1 ZNF282 ZNF576
Entrez ID		5603	8550
HPRD ID		09113	09467
Ensembl ID		ENSG00000156711	ENSG00000089022
Uniprot IDs		A0A024RD04 O15264	Q8IW41
PDB IDs		3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO 8X23
Enriched GO Terms of Interacting Partners?		MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction MAP Kinase Kinase Activity P38MAPK Cascade Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Response To Nerve Growth Factor Response To Growth Factor Main Axon Cellular Response To Nerve Growth Factor Stimulus Calcium-dependent Protein Serine/threonine Kinase Activity Brainstem Development Regulation Of Transforming Growth Factor Beta2 Production Cellular Response To Brain-derived Neurotrophic Factor Stimulus Protein Serine/threonine Kinase Activity Calmodulin Binding Protein-containing Complex Adult Locomotory Behavior Developmental Process Regulation Of Cell Communication Signal Transduction Negative Regulation Of Ferroptosis Regulation Of Ferroptosis Protein Kinase Activity Apolipoprotein Binding Identical Protein Binding Astrocyte Activation Apoptotic Process Response To Lead Ion Regulation Of Superoxide Anion Generation Regulation Of Signal Transduction Programmed Cell Death Cell Death Nucleus Positive Regulation Of Superoxide Anion Generation Immune System Process Calcium/calmodulin-dependent Protein Kinase Activity Mitogen-activated Protein Kinase Binding Positive Regulation Of Long-term Synaptic Potentiation Kinase Activity Regulation Of Programmed Cell Death Protein Serine Kinase Activity Amyloid Fibril Formation Regulation Of Superoxide Metabolic Process Protein Phosphatase 2A Binding Immune Response-activating Signaling Pathway Response To Oxidative Stress Central Nervous System Development	MAP Kinase Activity MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Cellular Response To Anisomycin Cytosol Kinase Activity Positive Regulation Of Cytokine Production Response To Anisomycin Nucleus Stress-activated MAPK Cascade Positive Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Protein Phosphorylation Response To Stress Cellular Response To Stress Phosphorylation Cytoplasm Animal Organ Development Regulation Of Gene Expression Regulation Of Cytokine Production Regulation Of Macromolecule Biosynthetic Process Phosphate-containing Compound Metabolic Process Protein Localization To Tricellular Tight Junction Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process ATP Binding Positive Regulation Of Biosynthetic Process Cellular Senescence Positive Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia P38MAPK Cascade Cellular Response To Radiation Regulation Of Macromolecule Metabolic Process Regulation Of Translation At Postsynapse Cellular Response To Oxygen-containing Compound Cellular Response To UV RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Apoptotic Process Transferase Activity Nucleotide Binding Cellular Response To Oxidative Stress Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Response To Oxidative Stress
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