MAPK13 and FGF12

Number of citations of the paper that reports this interaction (PMID 12244047)
17

Data Source:
BioGRID (enzymatic study)

		MAPK13	FGF12
Gene Name		mitogen-activated protein kinase 13	fibroblast growth factor 12
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Extracellular Space Nucleus
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Fibroblast Growth Factor Receptor Binding Growth Factor Activity Heparin Binding Sodium Channel Regulator Activity Ion Channel Binding
	Biological Process	MAPK Cascade Transcription, DNA-templated Regulation Of Transcription, DNA-templated Response To Stress Response To Osmotic Stress Cell Cycle Ras Protein Signal Transduction Peptidyl-serine Phosphorylation Positive Regulation Of Interleukin-6 Production Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Inflammatory Response	Regulation Of Membrane Depolarization Signal Transduction JNK Cascade Cell-cell Signaling Synaptic Transmission Nervous System Development Heart Development Adult Locomotory Behavior Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Sodium Ion Transport Neuromuscular Process Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Cation Channel Activity
Pathways		Signalling to ERKs Signalling by NGF DSCAM interactions Signaling by VEGF Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Signalling to RAS p38MAPK events NGF signalling via TRKA from the plasma membrane VEGFA-VEGFR2 Pathway Innate Immune System
Drugs
Diseases
GWAS			Ileal carcinoids ( 21139019) Major depressive disorder ( 23377640) Metabolite levels ( 19043545) Sleep quality ( 23728906)
Protein-Protein Interactions		15 interactors: AKIP1 ANKLE2 APP ATF2 EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4	13 interactors: APP COIL DACH1 DCTD IKZF1 LZTS2 MAPK13 MAPK8IP2 NEDD4 NEDD4L SRPK1 SRPK2 ZNF460
Entrez ID		5603	2257
HPRD ID		09113	03303
Ensembl ID		ENSG00000156711	ENSG00000114279
Uniprot IDs		O15264	P61328
PDB IDs		3COI 4EXU 4EYJ 4EYM	1Q1U
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Adult Locomotory Behavior Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Activation Of MAPK Activity Regulation Of Protein Phosphorylation Adult Behavior Toll-like Receptor 5 Signaling Pathway Developmental Process Toll-like Receptor 10 Signaling Pathway Phosphorylation Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Response To Stress Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of MAP Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta2 Production MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Protein Modification Process Locomotory Behavior MyD88-dependent Toll-like Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Toll-like Receptor 4 Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Toll-like Receptor Signaling Pathway Response To Organic Substance Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Signaling Positive Regulation Of Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cell Communication Regulation Of Kinase Activity	Negative Regulation Of Sodium Ion Transport RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Ion Transmembrane Transporter Activity Nucleobase-containing Compound Metabolic Process Regulation Of Transmembrane Transporter Activity Positive Regulation Of Viral Genome Replication Gene Expression Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Suckling Behavior Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Mating Behavior Regulation Of Potassium Ion Transmembrane Transport Protein Monoubiquitination Cellular Macromolecular Complex Assembly Nitrogen Compound Metabolic Process Negative Regulation Of Viral Genome Replication Regulation Of Membrane Potential Regulation Of Metabolic Process Mating Neuromuscular Junction Development Regulation Of Potassium Ion Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sodium Ion Transport Regulation Of MRNA Splicing, Via Spliceosome Response To Stress Positive Regulation Of Neutrophil Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Nuclear Speck Organization Transmission Of Virus Development Involved In Symbiotic Interaction Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Cellular Metabolic Process Negative Regulation Of Viral Process Response To Osmotic Stress Regulation Of MRNA Processing Regulation Of Synapse Structure Or Activity Synaptic Growth At Neuromuscular Junction Positive Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Ion Transport Regulation Of Ion Transmembrane Transport MRNA Processing Feeding Behavior
Tagcloud ?		alpha3 alpha3beta bap calcification calcifying ccl22 cd14 cd16 cd45 chi3l1 chit1 chitinase diaphyseal distinguished drilled femurs freshly fulfill gpnmb hole implanted ll monocytes monoosteophil monoosteophils osteoactivin osteopontin p38mapkdelta spp1	bisulfite breed broilers cgis chicken chickens contrasts cr1 differentially exons fgf14 fgf18 fgfr2 fgfr3 intergenic introns medip methylated poultry prominently recessive rock seq tails utrs validate wrr xh xinhua
Tagcloud (Difference) ?		alpha3 alpha3beta bap calcification calcifying ccl22 cd14 cd16 cd45 chi3l1 chit1 chitinase diaphyseal distinguished drilled femurs freshly fulfill gpnmb hole implanted ll monocytes monoosteophil monoosteophils osteoactivin osteopontin p38mapkdelta spp1	bisulfite breed broilers cgis chicken chickens contrasts cr1 differentially exons fgf14 fgf18 fgfr2 fgfr3 intergenic introns medip methylated poultry prominently recessive rock seq tails utrs validate wrr xh xinhua
Tagcloud (Intersection) ?