EEF2K and MAPKAPK5

Number of citations of the paper that reports this interaction (PubMedID 12171600)
25

Data Source:
HPRD (in vitro)

		EEF2K	MAPKAPK5
Description		eukaryotic elongation factor 2 kinase	MAPK activated protein kinase 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Postsynaptic Density Dendritic Spine Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Elongation Factor-2 Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding Translation Factor Activity, RNA Binding Kinase Activity Transferase Activity	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Response To Ischemia Translational Elongation Myosin II Filament Disassembly Cellular Response To Insulin Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Protein Autophosphorylation Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Anoxia Regulation Of Translation At Postsynapse Cellular Response To Brain-derived Neurotrophic Factor Stimulus Response To Prolactin	MAPK Cascade Regulation Of Translation Signal Transduction Ras Protein Signal Transduction Negative Regulation Of TOR Signaling Positive Regulation Of Telomere Maintenance Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Dendritic Spine Development Cellular Senescence Stress-induced Premature Senescence Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intracellular Signal Transduction
Pathways		mTORC1-mediated signalling	Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation
Drugs			Fostamatinib
Diseases
GWAS		Heel bone mineral density ( 30598549)	Adult body size ( 32376654) Body mass index ( 26426971) Coffee consumption ( 29367735) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean spheric corpuscular volume ( 32888494) Psoriasis ( 28537254) Spleen volume ( 34128465) Tea consumption ( 33080986)
Interacting Genes		17 interacting genes: CDK1 EEF2 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 PRKAA1 PRKAA2 PRKACA RPS6KA1 RPS6KB1 RPS6KB2	32 interacting genes: ATF2 CDCA8 EEF2K EIF4E EIF4EBP1 GYS1 HMGB1 HSPB1 HSPB2 JUN LSR MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK4 MAPK6 MAPK9 MBP MYH11 PARK7 PLA2G4A RPL13 SNCA SRPK1 SRPK2 TAB1 TP53 YAP1 ZNF282 ZNF576
Entrez ID		29904	8550
HPRD ID		07369	09467
Ensembl ID		ENSG00000103319	ENSG00000089022
Uniprot IDs		A0AAG2TFE4 O00418	Q8IW41
PDB IDs		5J8H 5KS5 6NX4 7SHQ 8FNY 8FO6 8GM4 8GM5
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Nucleotide Binding ATP Binding Transferase Activity Intracellular Signal Transduction MAP Kinase Activity MAPK Cascade Intracellular Signaling Cassette Post-transcriptional Regulation Of Gene Expression TORC1 Signaling Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Signal Transduction Positive Regulation Of Metabolic Process Protein Localization To Lipid Droplet Cellular Senescence Regulation Of TOR Signaling Stress-activated MAPK Cascade Response To Reactive Oxygen Species Stress-activated Protein Kinase Signaling Cascade Calcium-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Nucleoplasm Response To Oxidative Stress Cellular Response To Oxidative Stress Cellular Response To Oxygen-containing Compound Phosphorylation Nucleus Cellular Response To Reactive Oxygen Species Regulation Of Circadian Rhythm Regulation Of Translation Cytosol Protein Metabolic Process Positive Regulation Of Translational Initiation Nucleotide-activated Protein Kinase Complex Cellular Response To Chemical Stress Response To Nutrient Levels Cytoplasm Regulation Of Gene Expression Response To Stress Regulation Of Protein Metabolic Process	MAP Kinase Activity MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Cellular Response To Anisomycin Cytosol Kinase Activity Positive Regulation Of Cytokine Production Response To Anisomycin Nucleus Stress-activated MAPK Cascade Positive Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Protein Phosphorylation Response To Stress Cellular Response To Stress Phosphorylation Cytoplasm Animal Organ Development Regulation Of Gene Expression Regulation Of Cytokine Production Regulation Of Macromolecule Biosynthetic Process Phosphate-containing Compound Metabolic Process Protein Localization To Tricellular Tight Junction Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process ATP Binding Positive Regulation Of Biosynthetic Process Cellular Senescence Positive Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia P38MAPK Cascade Cellular Response To Radiation Regulation Of Macromolecule Metabolic Process Regulation Of Translation At Postsynapse Cellular Response To Oxygen-containing Compound Cellular Response To UV RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Apoptotic Process Transferase Activity Nucleotide Binding Cellular Response To Oxidative Stress Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Response To Oxidative Stress
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