EEF2K and MAPKAPK3

Number of citations of the paper that reports this interaction (PubMedID 12171600)
25

Data Source:
HPRD (in vitro)

		EEF2K	MAPKAPK3
Description		eukaryotic elongation factor 2 kinase	MAPK activated protein kinase 3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Postsynaptic Density Dendritic Spine Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Elongation Factor-2 Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding Translation Factor Activity, RNA Binding Kinase Activity Transferase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Response To Ischemia Translational Elongation Myosin II Filament Disassembly Cellular Response To Insulin Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Protein Autophosphorylation Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Anoxia Regulation Of Translation At Postsynapse Cellular Response To Brain-derived Neurotrophic Factor Stimulus Response To Prolactin	MAPK Cascade Toll-like Receptor Signaling Pathway Signal Transduction Response To Lipopolysaccharide Response To Cytokine Intracellular Signal Transduction Macropinocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways		mTORC1-mediated signalling	p38MAPK events Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation
Drugs			2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS		Heel bone mineral density ( 30598549)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) High light scatter reticulocyte count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		17 interacting genes: CDK1 EEF2 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 PRKAA1 PRKAA2 PRKACA RPS6KA1 RPS6KB1 RPS6KB2	21 interacting genes: APP ATF1 BECN1 COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM LINC02582 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A RCSD1 SMS SRPK2 SUMO3 TCF3 THAP12
Entrez ID		29904	7867
HPRD ID		07369	03678
Ensembl ID		ENSG00000103319	ENSG00000114738
Uniprot IDs		A0AAG2TFE4 O00418	Q16644
PDB IDs		5J8H 5KS5 6NX4 7SHQ 8FNY 8FO6 8GM4 8GM5	3FHR 3FXW 3R1N 3SHE 7NRB
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Nucleotide Binding ATP Binding Transferase Activity Intracellular Signal Transduction MAP Kinase Activity MAPK Cascade Intracellular Signaling Cassette Post-transcriptional Regulation Of Gene Expression TORC1 Signaling Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Signal Transduction Positive Regulation Of Metabolic Process Protein Localization To Lipid Droplet Cellular Senescence Regulation Of TOR Signaling Stress-activated MAPK Cascade Response To Reactive Oxygen Species Stress-activated Protein Kinase Signaling Cascade Calcium-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Nucleoplasm Response To Oxidative Stress Cellular Response To Oxidative Stress Cellular Response To Oxygen-containing Compound Phosphorylation Nucleus Cellular Response To Reactive Oxygen Species Regulation Of Circadian Rhythm Regulation Of Translation Cytosol Protein Metabolic Process Positive Regulation Of Translational Initiation Nucleotide-activated Protein Kinase Complex Cellular Response To Chemical Stress Response To Nutrient Levels Cytoplasm Regulation Of Gene Expression Response To Stress Regulation Of Protein Metabolic Process	Response To Growth Factor Cellular Response To Growth Factor Stimulus Receptor Catabolic Process Response To Hydrogen Peroxide Regulation Of Dendrite Development Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Potassium Ion Export Across Plasma Membrane Receptor Metabolic Process Regulation Of Synapse Organization Response To Metal Ion Positive Regulation Of Cell Cycle Response To Reactive Oxygen Species Sodium Channel Inhibitor Activity Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Dendrite Morphogenesis Potassium Channel Inhibitor Activity Cellular Response To Hydrogen Peroxide Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization Response To Stress Negative Regulation Of Sodium Ion Transport Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Cellular Response To UV MAP Kinase Activity Response To Lead Ion Regulation Of Cell Cycle Positive Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Protein Metabolic Process Regulation Of Protein Metabolic Process Response To Other Organism Cellular Response To Copper Ion Cellular Response To Light Stimulus Stress-activated MAPK Cascade Cellular Response To Reactive Oxygen Species Cellular Response To Chemical Stress Negative Regulation Of Potassium Ion Transmembrane Transport Intracellular Transport Cytosol Positive Regulation Of Transport Vesicle-mediated Transport Cellular Response To Stress P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Viral Budding Lysosomal Transport Intracellular Signaling Cassette Extracellular Exosome
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