EEF2K and RPS6KB2

Number of citations of the paper that reports this interaction (PubMedID 11500364)
48

Data Source:
HPRD (in vitro)

		EEF2K	RPS6KB2
Description		eukaryotic elongation factor 2 kinase	ribosomal protein S6 kinase B2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Postsynaptic Density Dendritic Spine Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Elongation Factor-2 Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding Translation Factor Activity, RNA Binding Kinase Activity Transferase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity ATP Binding Kinase Activity Transferase Activity Peptide Binding Protein Serine Kinase Activity
	Biological Process	Response To Ischemia Translational Elongation Myosin II Filament Disassembly Cellular Response To Insulin Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Protein Autophosphorylation Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Anoxia Regulation Of Translation At Postsynapse Cellular Response To Brain-derived Neurotrophic Factor Stimulus Response To Prolactin	Cytoplasmic Translation Translation Signal Transduction TOR Signaling TORC1 Signaling Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway
Pathways		mTORC1-mediated signalling	AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549)	Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		17 interacting genes: CDK1 EEF2 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 PRKAA1 PRKAA2 PRKACA RPS6KA1 RPS6KB1 RPS6KB2	22 interacting genes: BTK CFTR COASY EEF2K EP300 FBXO25 FYN HNRNPA1 IKBKG KAT2B LRRK2 LYN MAPK8IP2 MTOR NEDD4L PDGFRB PDPK1 PRKCE RPS6 SRC SRPK1 SYK
Entrez ID		29904	6199
HPRD ID		07369	10203
Ensembl ID		ENSG00000103319	ENSG00000175634
Uniprot IDs		A0AAG2TFE4 O00418	Q9UBS0
PDB IDs		5J8H 5KS5 6NX4 7SHQ 8FNY 8FO6 8GM4 8GM5
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Nucleotide Binding ATP Binding Transferase Activity Intracellular Signal Transduction MAP Kinase Activity MAPK Cascade Intracellular Signaling Cassette Post-transcriptional Regulation Of Gene Expression TORC1 Signaling Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Signal Transduction Positive Regulation Of Metabolic Process Protein Localization To Lipid Droplet Cellular Senescence Regulation Of TOR Signaling Stress-activated MAPK Cascade Response To Reactive Oxygen Species Stress-activated Protein Kinase Signaling Cascade Calcium-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Nucleoplasm Response To Oxidative Stress Cellular Response To Oxidative Stress Cellular Response To Oxygen-containing Compound Phosphorylation Nucleus Cellular Response To Reactive Oxygen Species Regulation Of Circadian Rhythm Regulation Of Translation Cytosol Protein Metabolic Process Positive Regulation Of Translational Initiation Nucleotide-activated Protein Kinase Complex Cellular Response To Chemical Stress Response To Nutrient Levels Cytoplasm Regulation Of Gene Expression Response To Stress Regulation Of Protein Metabolic Process	Cellular Response To Oxygen-containing Compound Protein Phosphorylation Kinase Activity Protein Kinase Activity Phosphorylation Transferase Activity Positive Regulation Of Cellular Component Organization Protein Modification Process Phospholipase Binding Peptidyl-tyrosine Phosphorylation Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Signaling Pathway ATP Binding Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cellular Response To Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Phospholipase Activator Activity Protein Metabolic Process Phosphate-containing Compound Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Nucleotide Binding Response To Hormone Regulation Of Innate Immune Response Innate Immune Response-activating Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Peptide Hormone T Cell Costimulation Cytoplasm Response To Stress Activation Of Innate Immune Response Positive Regulation Of Lymphocyte Activation Regulation Of Transport Immune Response-activating Signaling Pathway Protein Autophosphorylation Positive Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Positive Regulation Of Immune System Process Regulation Of Cellular Component Organization Transmembrane Transporter Binding Cellular Response To Nutrient Levels
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