EEF2K and EEF2

Number of citations of the paper that reports this interaction (PMID 8386634)
35

Data Source:
HPRD (in vitro)

		EEF2K	EEF2
Gene Name		eukaryotic elongation factor 2 kinase	eukaryotic translation elongation factor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Polysome Plasma Membrane Membrane Aggresome Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Elongation Factor-2 Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding Translation Factor Activity, Nucleic Acid Binding	Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Translation Activator Activity Protein Kinase Binding Poly(A) RNA Binding
	Biological Process	Translational Elongation Insulin Receptor Signaling Pathway Regulation Of Protein Autophosphorylation Protein Autophosphorylation	Hematopoietic Progenitor Cell Differentiation Translation Translational Elongation Pathogenesis Gene Expression Positive Regulation Of Gene Expression Peptidyl-diphthamide Biosynthetic Process From Peptidyl-histidine Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Translation
Pathways		Insulin receptor signalling cascade IRS-mediated signalling mTOR signalling S6K1-mediated signalling S6K1 signalling mTOR signalling IRS-related events mTORC1-mediated signalling IGF1R signaling cascade S6K1-mediated signalling mTORC1-mediated signalling IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) S6K1 signalling PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor	Synthesis of diphthamide-EEF2 Uptake and actions of bacterial toxins Translation Post-translational protein modification Peptide chain elongation Eukaryotic Translation Elongation Gamma carboxylation, hypusine formation and arylsulfatase activation Uptake and function of diphtheria toxin
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: CDK1 EEF2 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 PRKAA1 PRKAA2 PRKACA RPS6KA1 RPS6KB1 RPS6KB2	16 interactors: CCT2 CDKN2A DISC1 EEF2K EEF2KMT HNRNPD MAPKAPK3 MLH1 NDRG1 PPM1A PPP2CA PPP2R1A PPP2R1B TP53 TRPM7 UCHL5
Entrez ID		29904	1938
HPRD ID		07369	00561
Ensembl ID			ENSG00000167658
Uniprot IDs		O00418	B4DPU3 P13639
PDB IDs			3J3A
Enriched GO Terms of Interacting Partners?		Peptidyl-serine Phosphorylation Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway MAPK Cascade Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Signal Transduction By Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Protein Modification Process Toll-like Receptor Signaling Pathway Cellular Response To Organic Substance Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Phosphate-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Response To Organic Substance Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To Stress Ras Protein Signal Transduction Regulation Of Innate Immune Response Peptidyl-amino Acid Modification Activation Of MAPK Activity Activation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway	Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Death Negative Regulation Of Cell Growth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein RNA Catabolic Process Positive Regulation Of Cell Aging Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Growth Mitotic Nuclear Envelope Reassembly Apoptotic Process Cell Cycle Process Nuclear Envelope Reassembly Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Wnt Signaling Pathway Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Replicative Senescence Regulation Of Cell Growth Gene Expression Positive Regulation Of Protein Metabolic Process Regulation Of DNA Replication Cellular Response To Organic Substance Signaling Cell Communication Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Negative Regulation Of JAK-STAT Cascade Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Arrest Nuclear-transcribed MRNA Catabolic Process Cell Cycle MRNA Catabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Cellular Metabolic Process Aromatic Compound Catabolic Process
Tagcloud ?		atherosclerosis atherosclerotic beneficial chimeras compartment contributes diet dramatically elongation eukaryotic explanation fat feeding hematopoietic inhibiting knock ldlr lesser m1 macrophages mutant necrosis plaque providing sixteen skewed suppresses transplanting tumour	4e acutely alleviation assembly bps consequence consequent dephosphorylation eif2b eif4e eif4f elongation glycogen initiation involve mrnas p70 phosphatidylinositol polypyrimidine ribosomal s6 signalling steps stimulates termed tracts translation untranslated utrs
Tagcloud (Difference) ?		atherosclerosis atherosclerotic beneficial chimeras compartment contributes diet dramatically eukaryotic explanation fat feeding hematopoietic inhibiting knock ldlr lesser m1 macrophages mutant necrosis plaque providing sixteen skewed suppresses transplanting tumour	4e acutely alleviation assembly bps consequence consequent dephosphorylation eif2b eif4e eif4f glycogen initiation involve mrnas p70 phosphatidylinositol polypyrimidine ribosomal s6 signalling steps stimulates termed tracts translation untranslated utrs
Tagcloud (Intersection) ?		elongation