EEF2K and MAPK11

Number of citations of the paper that reports this interaction (PMID 12171600)
22

Data Source:
HPRD (in vitro)

		EEF2K	MAPK11
Gene Name		eukaryotic elongation factor 2 kinase	mitogen-activated protein kinase 11
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Nucleoplasm Cytosol
	Molecular Function	Protein Kinase Activity Elongation Factor-2 Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding Translation Factor Activity, Nucleic Acid Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	Translational Elongation Insulin Receptor Signaling Pathway Regulation Of Protein Autophosphorylation Protein Autophosphorylation	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Protein Phosphorylation Response To Stress Organelle Organization Mitochondrion Organization Signal Transduction Ras Protein Signal Transduction Gene Expression Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Muscle Cell Differentiation Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade
Pathways		Insulin receptor signalling cascade IRS-mediated signalling mTOR signalling S6K1-mediated signalling S6K1 signalling mTOR signalling IRS-related events mTORC1-mediated signalling IGF1R signaling cascade S6K1-mediated signalling mTORC1-mediated signalling IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) S6K1 signalling PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor	Cellular Senescence Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway p38MAPK events MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements CDO in myogenesis TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade Activation of PPARGC1A (PGC-1alpha) by phosphorylation Myogenesis Signaling by VEGF Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Signalling to RAS Signalling to ERKs Organelle biogenesis and maintenance Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway Activated TLR4 signalling Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Mitochondrial biogenesis Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade DSCAM interactions Oxidative Stress Induced Senescence KSRP destabilizes mRNA Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: CDK1 EEF2 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 PRKAA1 PRKAA2 PRKACA RPS6KA1 RPS6KB1 RPS6KB2	27 interactors: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK3 MAPKAPK5 MAPT MBP NOXA1 PML POLR3D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1
Entrez ID		29904	5600
HPRD ID		07369	04208
Ensembl ID			ENSG00000185386
Uniprot IDs		O00418	L7RT27 Q15759
PDB IDs			3GC8 3GC9 3GP0
Enriched GO Terms of Interacting Partners?		Peptidyl-serine Phosphorylation Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway MAPK Cascade Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Signal Transduction By Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Protein Modification Process Toll-like Receptor Signaling Pathway Cellular Response To Organic Substance Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Phosphate-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Response To Organic Substance Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To Stress Ras Protein Signal Transduction Regulation Of Innate Immune Response Peptidyl-amino Acid Modification Activation Of MAPK Activity Activation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway	Regulation Of Innate Immune Response Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MAPK Cascade MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Toll-like Receptor 4 Signaling Pathway Innate Immune Response Response To Stress Signal Transduction By Phosphorylation Regulation Of Immune Response Cellular Response To Stress Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Response To Organic Substance Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Immune Response Phosphorylation Signaling Cellular Response To Organic Substance Regulation Of Signal Transduction Cell Communication Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Signaling Immune System Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Lipid Response To Growth Factor Intracellular Signal Transduction Regulation Of Growth
Tagcloud ?		atherosclerosis atherosclerotic beneficial chimeras compartment contributes diet dramatically elongation eukaryotic explanation fat feeding hematopoietic inhibiting knock ldlr lesser m1 macrophages mutant necrosis plaque providing sixteen skewed suppresses transplanting tumour	antagonists antitumor bbc3 bcl2 ca cacna1g caco2 cdkn1a channel channels express hct116 knockdown mapkalpha occupancy p21cip1 p38 p53 p53wt promoted puma rationale rnai sb203580 ser392 stably thought
Tagcloud (Difference) ?		atherosclerosis atherosclerotic beneficial chimeras compartment contributes diet dramatically elongation eukaryotic explanation fat feeding hematopoietic inhibiting knock ldlr lesser m1 macrophages mutant necrosis plaque providing sixteen skewed suppresses transplanting tumour	antagonists antitumor bbc3 bcl2 ca cacna1g caco2 cdkn1a channel channels express hct116 knockdown mapkalpha occupancy p21cip1 p38 p53 p53wt promoted puma rationale rnai sb203580 ser392 stably thought
Tagcloud (Intersection) ?