DUSP10 and CMTM6

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		DUSP10	CMTM6
Name		dual specificity phosphatase 10	CKLF like MARVEL transmembrane domain containing 6
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Endosome Plasma Membrane Membrane Early Endosome Membrane Azurophil Granule Membrane Specific Granule Membrane Recycling Endosome Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity JUN Kinase Binding Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Mitogen-activated Protein Kinase P38 Binding	Protein Binding
	Biological Process	Regulation Of Immune System Process Regulation Of Adaptive Immune Response Signal Transduction Negative Regulation Of Epithelial Cell Migration Dephosphorylation Negative Regulation Of Cell Migration Response To Lipopolysaccharide Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of JNK Cascade Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Process Stress-activated MAPK Cascade Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of Cell Development Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Brown Fat Cell Differentiation Negative Regulation Of P38MAPK Cascade Negative Regulation Of Epithelium Regeneration	Protein Transport Regulation Of Protein Stability Endocytic Recycling
Pathways		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Signaling by MAPK mutants	Neutrophil degranulation
GWAS		Cluster headache ( 34184781 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Colorectal cancer ( 20972440 24836286 25990418 29471430 ) Colorectal cancer or advanced adenoma ( 30510241 ) Copper levels ( 26025379 ) Lung function (FEV1) ( 30061609 ) Lung function (FVC) ( 30061609 ) Progressive supranuclear palsy ( 30089514 ) Serum thyroid-stimulating hormone levels ( 25436638 ) Tonsillectomy ( 27182965 28928442 ) White matter lesion progression ( 26451028 ) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028 )	Apolipoprotein B levels ( 32203549 ) Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction) ( 33012170 ) Cholesterol, total ( 24097068 ) LDL cholesterol ( 24097068 30275531 ) LDL cholesterol levels ( 28334899 32203549 ) Low density lipoprotein cholesterol levels ( 32154731 ) Total cholesterol levels ( 28334899 30275531 )
Interacting Genes		21 interacting genes: CMTM6 CNKSR1 ERBB4 FHL2 FN1 FNDC3B HOXA1 HTT IGF1R KRTAP3-2 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 PTK7 ROR2 RPS11 SLX1B SNX2	23 interacting genes: APOA5 ATP13A2 BPIFA2 CD160 CD40 CIAO2A COQ8A DNMT3B DUSP10 ECPAS EHHADH FAM9B MIEF1 PPBP RBFA RBMX RUSC1 SNRPB2 SPG21 SUMO2 TCEA2 TMED8 XRCC6
Entrez ID		11221	54918
HPRD ID		12320	06987
Ensembl ID		ENSG00000143507	ENSG00000091317
Uniprot IDs		Q9Y6W6	Q9NX76
PDB IDs		1ZZW 2OUC 2OUD 3TG1 6MC1 7U4O 7U4R 7UMU 7UMV 7UN0 7UN4 7Y4B 7Y4C 7Y4D 7Y4E	Not available
GO Terms Enriched among Interactors		MAP Kinase Activity Protein Kinase Activity Kinase Activity JUN Kinase Activity Cellular Senescence Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Protein Phosphorylation Protein Serine Kinase Activity ATP Binding Phosphorylation MAPK Cascade Positive Regulation Of Cellular Component Organization Protein Serine/threonine Kinase Activity Positive Regulation Of Cyclase Activity Fc-epsilon Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Canonical Inflammasome Complex Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Autophosphorylation Regulation Of Cardiac Muscle Cell Proliferation Transferase Activity Nucleotide Binding Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity NLRP1 Inflammasome Complex Assembly Response To Light Stimulus Fc Receptor Signaling Pathway Outer Ear Morphogenesis Peptidyl-tyrosine Autophosphorylation JNK Cascade Intracellular Signaling Cassette Regulation Of Heart Growth Positive Regulation Of Telomere Maintenance Enzyme-linked Receptor Protein Signaling Pathway Axon Cellular Response To UV-B MAP Kinase Kinase Activity Response To Radiation Regulation Of Organ Growth Protein Phosphatase Binding Positive Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Protein Metabolic Process Response To UV-B Establishment Of Planar Polarity ERBB2 Signaling Pathway Positive Regulation Of Organelle Organization Insulin Receptor Binding Regulation Of Telomere Maintenance	None