DUSP10 and RPS11

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		DUSP10	RPS11
Gene Name		dual specificity phosphatase 10	ribosomal protein S11
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus	Cytosol Ribosome Focal Adhesion Membrane Cytosolic Small Ribosomal Subunit Extracellular Vesicular Exosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity	Structural Constituent Of Ribosome Protein Binding RRNA Binding Poly(A) RNA Binding
	Biological Process	Inactivation Of MAPK Activity Regulation Of Adaptive Immune Response Protein Dephosphorylation Response To Stress JNK Cascade Response To Lipopolysaccharide Peptidyl-tyrosine Dephosphorylation Negative Regulation Of JUN Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Negative Regulation Of JNK Cascade Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of Brown Fat Cell Differentiation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Osteoblast Differentiation Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways			Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Colorectal cancer ( 20972440)	Hematological and biochemical traits ( 20139978) Metabolite levels ( 21909109) Serum albumin level ( 23022100) Serum total protein level ( 23022100)
Protein-Protein Interactions		12 interactors: CMTM6 FHL2 FN1 HTT MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 RPS11 SLX1B SNX2	4 interactors: APP DUSP10 MAP3K14 RPL30
Entrez ID		11221	6205
HPRD ID		12320	01599
Ensembl ID		ENSG00000143507	ENSG00000142534
Uniprot IDs		B4DDQ0 Q9Y6W6	P62280
PDB IDs		1ZZW 2OUC 2OUD 3TG1	3J3A
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response MAPK Cascade Regulation Of Innate Immune Response Signal Transduction By Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Activation Of MAPK Activity Immune Response-regulating Signaling Pathway JUN Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Neurotrophin Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Immune Response Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Defense Response Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Cellular Response To Lipid Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of Immune System Process Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Cellular Response To Lipopolysaccharide Response To Radiation Response To Stress Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Protein Kinase Activity	Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Synaptic Growth At Neuromuscular Junction Regulation Of Protein Phosphorylation Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Collateral Sprouting In Absence Of Injury MAPK Cascade Regulation Of Phosphorylation Collateral Sprouting Axon Midline Choice Point Recognition Signal Transduction By Phosphorylation Negative Regulation Of Neurogenesis Regulation Of MAP Kinase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Brown Fat Cell Differentiation Axon Choice Point Recognition Negative Regulation Of Cell Development Cellular Protein Metabolic Process Neuron Remodeling Response To External Stimulus Phosphorylation Regulation Of Respiratory Burst Negative Regulation Of JUN Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process MRNA Metabolic Process Protein Metabolic Process Cellular Copper Ion Homeostasis Negative Regulation Of Oligodendrocyte Differentiation Copper Ion Homeostasis Suckling Behavior Regulation Of Catalytic Activity Regulation Of MAPK Cascade Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Neurogenesis Negative Regulation Of JNK Cascade Inactivation Of MAPK Activity Negative Regulation Of Cell Differentiation Mating Behavior Regulation Of Signal Transduction Negative Regulation Of Stress-activated MAPK Cascade Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Glial Cell Differentiation RNA Polyadenylation Neuron Recognition
Tagcloud ?		bc bcs dephosphorylate differentially distant dmfs dusp4 dusp6 enpp1 erbb2 erk ihc inpp4b microarray microarrays motility multiphosphatase phosphatases phosphatome phospho ppapdc1a relevance seemed series sharing signature subgroups unlike warranted	apocytochrome infa l20 l22 l33 liverwort marchantia peta petb petd preprotein psbb psbe psbf psbh rpl14 rpl16 rpl2 rpl20 rpl22 rpl23 rpl33 rpoa rps12 rps18 rps3 rps8 secx ugg
Tagcloud (Difference) ?		bc bcs dephosphorylate differentially distant dmfs dusp4 dusp6 enpp1 erbb2 erk ihc inpp4b microarray microarrays motility multiphosphatase phosphatases phosphatome phospho ppapdc1a relevance seemed series sharing signature subgroups unlike warranted	apocytochrome infa l20 l22 l33 liverwort marchantia peta petb petd preprotein psbb psbe psbf psbh rpl14 rpl16 rpl2 rpl20 rpl22 rpl23 rpl33 rpoa rps12 rps18 rps3 rps8 secx ugg
Tagcloud (Intersection) ?