DUSP10 and MAPK10

Number of citations: 0 (PubMedID 11359773)
Data Source: HPRD (in vitro)

		DUSP10	MAPK10
Name		dual specificity phosphatase 10	mitogen-activated protein kinase 10
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity JUN Kinase Binding Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Mitogen-activated Protein Kinase P38 Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Immune System Process Regulation Of Adaptive Immune Response Signal Transduction Negative Regulation Of Epithelial Cell Migration Dephosphorylation Negative Regulation Of Cell Migration Response To Lipopolysaccharide Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of JNK Cascade Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Process Stress-activated MAPK Cascade Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of Cell Development Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Brown Fat Cell Differentiation Negative Regulation Of P38MAPK Cascade Negative Regulation Of Epithelium Regeneration	MAPK Cascade Protein Phosphorylation Signal Transduction JNK Cascade Response To Light Stimulus Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Cellular Senescence
Pathways		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Signaling by MAPK mutants	Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors
Drugs		None	Minocycline Pyrazolanthrone Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine 9-(4-Hydroxyphenyl)-2,7-Phenanthroline Phosphoaminophosphonic Acid-Adenylate Ester N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide 1-(3-bromophenyl)-7-chloro-6-methoxy-3,4-dihydroisoquinoline Fostamatinib Halicin
GWAS		Cluster headache ( 34184781 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Colorectal cancer ( 20972440 24836286 25990418 29471430 ) Colorectal cancer or advanced adenoma ( 30510241 ) Copper levels ( 26025379 ) Lung function (FEV1) ( 30061609 ) Lung function (FVC) ( 30061609 ) Progressive supranuclear palsy ( 30089514 ) Serum thyroid-stimulating hormone levels ( 25436638 ) Tonsillectomy ( 27182965 28928442 ) White matter lesion progression ( 26451028 ) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028 )	Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216 ) Cobalt levels ( 26025379 ) Diisocyanate-induced asthma ( 25918132 ) Gait speed in old age ( 28077804 ) Liver enzyme levels (alanine transaminase) ( 22001757 33972514 ) Multiple sclerosis ( 31604244 ) Peripheral artery disease ( 25009551 ) Response to cytidine analogues (gemcitabine) ( 24483146 ) Triglyceride levels ( 32154731 32203549 )
Interacting Genes		21 interacting genes: CMTM6 CNKSR1 ERBB4 FHL2 FN1 FNDC3B HOXA1 HTT IGF1R KRTAP3-2 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 PTK7 ROR2 RPS11 SLX1B SNX2	40 interacting genes: APP ARRB1 ARRB2 ATF2 BCL2L11 CDK5 CDKN1B CDKN2A CDKN2C CEP290 CREBBP DUSP10 DUSP16 DUSP9 ELK1 FBXO7 GTF3C1 HAX1 HDAC9 HNRNPK HRAS JUN KIF26A KIF5A LDHA MAP2K4 MAPK8IP2 MAPK8IP3 MAPKBP1 MAPT MCL1 PKMYT1 PLIN2 RELA SH3BP5 STMN2 TNIP1 TP53 UBE3A UNC119
Entrez ID		11221	5602
HPRD ID		12320	04207
Ensembl ID		ENSG00000143507	ENSG00000109339
Uniprot IDs		Q9Y6W6	A0A286YEQ0 A0A286YF97 D6RJF9 F8W9R5 P53779 Q499Y8
PDB IDs		1ZZW 2OUC 2OUD 3TG1 6MC1 7U4O 7U4R 7UMU 7UMV 7UN0 7UN4 7Y4B 7Y4C 7Y4D 7Y4E	1JNK 1PMN 1PMU 1PMV 2B1P 2EXC 2O0U 2O2U 2OK1 2P33 2R9S 2WAJ 2ZDT 2ZDU 3CGF 3CGO 3DA6 3FI2 3FI3 3FV8 3G90 3G9L 3G9N 3KVX 3OXI 3OY1 3PTG 3RTP 3TTI 3TTJ 3V6R 3V6S 4H36 4H39 4H3B 4KKE 4KKG 4KKH 4U79 4W4V 4W4W 4W4X 4W4Y 4WHZ 4X21 4Y46 4Y5H 4Z9L 6EKD 6EMH 6EQ9 7KSI 7KSJ 7KSK 7ORE 7ORF 7S1N 7YL1 8BZP 8ENJ 8VNX 8VO4 8VS0 8VTF 8WGF
GO Terms Enriched among Interactors		MAP Kinase Activity Protein Kinase Activity Kinase Activity JUN Kinase Activity Cellular Senescence Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Protein Phosphorylation Protein Serine Kinase Activity ATP Binding Phosphorylation MAPK Cascade Positive Regulation Of Cellular Component Organization Protein Serine/threonine Kinase Activity Positive Regulation Of Cyclase Activity Fc-epsilon Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Canonical Inflammasome Complex Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Autophosphorylation Regulation Of Cardiac Muscle Cell Proliferation Transferase Activity Nucleotide Binding Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity NLRP1 Inflammasome Complex Assembly Response To Light Stimulus Fc Receptor Signaling Pathway Outer Ear Morphogenesis Peptidyl-tyrosine Autophosphorylation JNK Cascade Intracellular Signaling Cassette Regulation Of Heart Growth Positive Regulation Of Telomere Maintenance Enzyme-linked Receptor Protein Signaling Pathway Axon Cellular Response To UV-B MAP Kinase Kinase Activity Response To Radiation Regulation Of Organ Growth Protein Phosphatase Binding Positive Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Protein Metabolic Process Response To UV-B Establishment Of Planar Polarity ERBB2 Signaling Pathway Positive Regulation Of Organelle Organization Insulin Receptor Binding Regulation Of Telomere Maintenance	Cytoplasm Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Neuron Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling JUN Kinase Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Nucleus Regulation Of Apoptotic Process MAPK Cascade Regulation Of Programmed Cell Death Cytosol Regulation Of Protein Modification Process Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Signal Transduction RNA Polymerase II-specific DNA-binding Transcription Factor Binding JNK Cascade MAP Kinase Tyrosine Phosphatase Activity Cellular Senescence Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Process Signal Transduction Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Tyrosine/threonine Phosphatase Activity Protein Kinase Binding Programmed Cell Death Regulation Of Growth Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of JNK Cascade Regulation Of Post-translational Protein Modification Negative Regulation Of Multicellular Organismal Process Regulation Of MiRNA Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Post-translational Protein Modification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription General Transcription Initiation Factor Binding Nucleoplasm Regulation Of Apoptotic Signaling Pathway