DUSP10 and SLX1B

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		DUSP10	SLX1B
Name		dual specificity phosphatase 10	structure-specific endonuclease subunit SLX1B
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Slx1-Slx4 Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity JUN Kinase Binding Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Mitogen-activated Protein Kinase P38 Binding	Nuclease Activity Endonuclease Activity Protein Binding Zinc Ion Binding Crossover Junction DNA Endonuclease Activity Hydrolase Activity 5'-flap Endonuclease Activity Metal Ion Binding
	Biological Process	Regulation Of Immune System Process Regulation Of Adaptive Immune Response Signal Transduction Negative Regulation Of Epithelial Cell Migration Dephosphorylation Negative Regulation Of Cell Migration Response To Lipopolysaccharide Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of JNK Cascade Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Process Stress-activated MAPK Cascade Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of Cell Development Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Brown Fat Cell Differentiation Negative Regulation Of P38MAPK Cascade Negative Regulation Of Epithelium Regeneration	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Lengthening Regulation Of Telomere Maintenance Telomeric D-loop Disassembly T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Signaling by MAPK mutants	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
GWAS		Cluster headache ( 34184781 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Colorectal cancer ( 20972440 24836286 25990418 29471430 ) Colorectal cancer or advanced adenoma ( 30510241 ) Copper levels ( 26025379 ) Lung function (FEV1) ( 30061609 ) Lung function (FVC) ( 30061609 ) Progressive supranuclear palsy ( 30089514 ) Serum thyroid-stimulating hormone levels ( 25436638 ) Tonsillectomy ( 27182965 28928442 ) White matter lesion progression ( 26451028 ) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028 )	No GWAS studies recorded
Interacting Genes		21 interacting genes: CMTM6 CNKSR1 ERBB4 FHL2 FN1 FNDC3B HOXA1 HTT IGF1R KRTAP3-2 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 PTK7 ROR2 RPS11 SLX1B SNX2	3 interacting genes: DUSP10 THAP11 TUBA1B
Entrez ID		11221	79008
HPRD ID		12320	14673
Ensembl ID		ENSG00000143507	ENSG00000181625
Uniprot IDs		Q9Y6W6	Q9BQ83
PDB IDs		1ZZW 2OUC 2OUD 3TG1 6MC1 7U4O 7U4R 7UMU 7UMV 7UN0 7UN4 7Y4B 7Y4C 7Y4D 7Y4E	Not available
GO Terms Enriched among Interactors		MAP Kinase Activity Protein Kinase Activity Kinase Activity JUN Kinase Activity Cellular Senescence Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Protein Phosphorylation Protein Serine Kinase Activity ATP Binding Phosphorylation MAPK Cascade Positive Regulation Of Cellular Component Organization Protein Serine/threonine Kinase Activity Positive Regulation Of Cyclase Activity Fc-epsilon Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Canonical Inflammasome Complex Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Autophosphorylation Regulation Of Cardiac Muscle Cell Proliferation Transferase Activity Nucleotide Binding Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity NLRP1 Inflammasome Complex Assembly Response To Light Stimulus Fc Receptor Signaling Pathway Outer Ear Morphogenesis Peptidyl-tyrosine Autophosphorylation JNK Cascade Intracellular Signaling Cassette Regulation Of Heart Growth Positive Regulation Of Telomere Maintenance Enzyme-linked Receptor Protein Signaling Pathway Axon Cellular Response To UV-B MAP Kinase Kinase Activity Response To Radiation Regulation Of Organ Growth Protein Phosphatase Binding Positive Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Protein Metabolic Process Response To UV-B Establishment Of Planar Polarity ERBB2 Signaling Pathway Positive Regulation Of Organelle Organization Insulin Receptor Binding Regulation Of Telomere Maintenance	Negative Regulation Of Epithelium Regeneration DTTP Catabolic Process DCTP Diphosphatase Activity DCTP Catabolic Process Pyrimidine Deoxyribonucleotide Binding Regulation Of Epithelium Regeneration Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of Respiratory Burst Mitogen-activated Protein Kinase P38 Binding MAP Kinase Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Nucleoside Triphosphate Diphosphatase Activity DNA Protection Protein Tyrosine/threonine Phosphatase Activity Regulation Of Respiratory Burst Involved In Inflammatory Response JUN Kinase Binding Negative Regulation Of P38MAPK Cascade Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Mitochondrial Transcription Nucleoside Triphosphate Catabolic Process Pyrophosphatase Activity Hydrolase Activity Negative Regulation Of Oligodendrocyte Differentiation MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Negative Regulation Of Epithelial Cell Migration Pyrimidine Deoxyribonucleotide Catabolic Process Regulation Of Respiratory Burst Cellular Response To Interleukin-4 Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Glial Cell Differentiation Stress-activated Protein Kinase Signaling Cascade Stress-activated MAPK Cascade Pyrimidine-containing Compound Catabolic Process Response To Interleukin-4 Deoxyribose Phosphate Catabolic Process Deoxyribonucleotide Catabolic Process