DUSP10 and FNDC3B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DUSP10	FNDC3B
Description		dual specificity phosphatase 10	fibronectin type III domain containing 3B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Endomembrane System Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity JUN Kinase Binding Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Mitogen-activated Protein Kinase P38 Binding	RNA Binding Protein Binding
	Biological Process	Regulation Of Immune System Process Regulation Of Adaptive Immune Response Signal Transduction Negative Regulation Of Epithelial Cell Migration Dephosphorylation Negative Regulation Of Cell Migration Response To Lipopolysaccharide Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of JNK Cascade Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Process Stress-activated MAPK Cascade Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of Cell Development Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Brown Fat Cell Differentiation Negative Regulation Of P38MAPK Cascade Negative Regulation Of Epithelium Regeneration
Pathways		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs
Diseases
GWAS		Cluster headache ( 34184781) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal cancer ( 20972440 24836286 25990418 29471430) Colorectal cancer or advanced adenoma ( 30510241) Copper levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Progressive supranuclear palsy ( 30089514) Serum thyroid-stimulating hormone levels ( 25436638) Tonsillectomy ( 27182965 28928442) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)	Appendicular lean mass ( 33097823) Bell's palsy ( 33602968) Central corneal thickness ( 29760442 30894546 31798171 32528159) Corneal hysteresis ( 30894546) Corneal resistance factor ( 30894546 31246245) Corneal structure ( 23291589) Coronary artery disease ( 33020668 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma (primary open-angle) ( 33627673) Glycated hemoglobin levels ( 34059833 28898252) Heart rate ( 23583979) Height ( 31562340 33713608 23563607 28552196 25282103 25429064) Hip circumference adjusted for BMI ( 28552196 34021172 25673412) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Immature fraction of reticulocytes ( 32888494 27863252) Intraocular pressure ( 25173106 31798171 28073927 29785010 30054594 29617998 29235454) Intraocular pressure (Goldman correlated) ( 30894546) Keratoconus ( 33649486) Mean corpuscular hemoglobin ( 32888494) Myocardial infarction ( 33532862) Parkinson's disease ( 26227905) PR interval ( 32439900) Pulse pressure ( 30224653) Red cell distribution width ( 32888494 27863252 28957414) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triptolide cytotoxicity ( 26121980) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		21 interacting genes: CMTM6 CNKSR1 ERBB4 FHL2 FN1 FNDC3B HOXA1 HTT IGF1R KRTAP3-2 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 PTK7 ROR2 RPS11 SLX1B SNX2	124 interacting genes: ABHD11 ABHD8 ACTG1 ACTMAP ADGRF5 AHNAK ALB ANXA2 ATP1A1 ATP5F1A BBS2 BICRAL BRWD1 C10orf55 C22orf15 CAMK2D CAP1 CAPN3 CDC42 CEMP1 CFL1 DAPL1 DSTN DUSP10 EEF1E1 EGFR EIF5A2 ENO1 ERCC6 ERH ERI3 FUS GAS2L3 GOLT1B GTF2F1 HAPLN2 HNRNPD HNRNPK HSP90AB4P HSPA1A HSPA5 HSPA7 HSPA8 HSPB1 HSPD1 HSPH1 KARS1 KLHDC7B KRTAP11-1 L3MBTL3 LARP4 MBD3L1 MBOAT7 MCCD1 MVP MYH14 MYL6 NAGK NCAM2 NCK1 NDUFAB1 P4HB PARP1 PC PGK1 PIK3R4 PKLR POGZ POU6F2 PPP6R2 PRKAA2 PSMA3 PTMA RAB1A RAB1B RAN REL RPL12 RPL15 RPL17 RPL23 RPL28 RPL34 RPS14 RPS3 RPS3A RPS6 RUSC1 SNRPD3 SOD1 SPCS2 SPMIP10 SPMIP5 SPSB2 SRARP STPG4 SUGT1 SUOX SYNCRIP TEKT5 TEPSIN TESMIN TEX48 TGM2 TIAM1 TKT TOX4 TPM3 TRAF2 TRIM16 TRIM35 TRIM42 TRIP13 TTN TUBB4A TUBGCP6 TXN UBA52 UBAP2 USP54 VAC14 YPEL3 YWHAZ ZMYND19
Entrez ID		11221	64778
HPRD ID		12320	10943
Ensembl ID		ENSG00000143507	ENSG00000075420
Uniprot IDs		Q9Y6W6	Q53EP0
PDB IDs		1ZZW 2OUC 2OUD 3TG1 6MC1 7U4O 7U4R 7UMU 7UMV 7UN0 7UN4 7Y4B 7Y4C 7Y4D 7Y4E
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity Protein Kinase Activity Kinase Activity JUN Kinase Activity Cellular Senescence Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Protein Phosphorylation Protein Serine Kinase Activity ATP Binding Phosphorylation MAPK Cascade Positive Regulation Of Cellular Component Organization Protein Serine/threonine Kinase Activity Positive Regulation Of Cyclase Activity Fc-epsilon Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Canonical Inflammasome Complex Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Autophosphorylation Regulation Of Cardiac Muscle Cell Proliferation Transferase Activity Nucleotide Binding Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity NLRP1 Inflammasome Complex Assembly Response To Light Stimulus Fc Receptor Signaling Pathway Outer Ear Morphogenesis Peptidyl-tyrosine Autophosphorylation JNK Cascade Intracellular Signaling Cassette Regulation Of Heart Growth Positive Regulation Of Telomere Maintenance Enzyme-linked Receptor Protein Signaling Pathway Axon Cellular Response To UV-B MAP Kinase Kinase Activity Response To Radiation Regulation Of Organ Growth Protein Phosphatase Binding Positive Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Protein Metabolic Process Response To UV-B Establishment Of Planar Polarity ERBB2 Signaling Pathway Positive Regulation Of Organelle Organization Insulin Receptor Binding Regulation Of Telomere Maintenance	Extracellular Exosome Cytosol Cytoplasm Cytoplasmic Translation Cytosolic Ribosome Focal Adhesion Ribonucleoprotein Complex RNA Binding ATP-dependent Protein Folding Chaperone Translation Structural Constituent Of Ribosome Ribosome Protein Refolding Cadherin Binding Cytosolic Large Ribosomal Subunit Protein-containing Complex Melanosome Protein Binding Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding ATP Metabolic Process Protein Metabolic Process Protein Phosphatase Binding Cytosolic Small Ribosomal Subunit Regulation Of Intrinsic Apoptotic Signaling Pathway Protein-folding Chaperone Binding Nucleotide Binding Response To Nitric Oxide Protein Folding Positive Regulation Of Protein Metabolic Process Organophosphate Metabolic Process Enzyme Binding Actin Filament-based Process Macromolecule Metabolic Process Nucleotide Metabolic Process Nucleus Vesicle Structural Molecule Activity Conferring Elasticity Purine Nucleotide Metabolic Process Protein Folding Chaperone Nucleobase-containing Small Molecule Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway ATP Binding Positive Regulation Of Gene Expression Nicotinamide Nucleotide Metabolic Process Unfolded Protein Binding Nucleoside Phosphate Metabolic Process Cellular Response To Nitric Oxide
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?