CAMP and FPR2

Number of citations of the paper that reports this interaction (PubMedID 11015447)
29

Data Source:
HPRD (in vivo)

		CAMP	FPR2
Description		cathelicidin antimicrobial peptide	formyl peptide receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Vesicle Specific Granule Lumen Specific Granule Cell Projection Extracellular Exosome Tertiary Granule Lumen	Cytoplasm Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Lipopolysaccharide Binding Protein Binding	Amyloid-beta Binding Complement Receptor Activity G Protein-coupled Receptor Activity N-formyl Peptide Receptor Activity Scavenger Receptor Binding Protein Binding Signaling Receptor Activity Cargo Receptor Activity RAGE Receptor Binding
	Biological Process	Response To Yeast Innate Immune Response In Mucosa Immune System Process Prostaglandin Production Involved In Inflammatory Response Chronic Inflammatory Response Positive Regulation Of Antimicrobial Humoral Response Defense Response Positive Regulation Of Cell Population Proliferation Response To Glucose Leukotriene Biosynthetic Process Antibacterial Humoral Response Antifungal Humoral Response Cytolysis Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Modulation Of Process Of Another Organism Neutrophil Activation Defense Response To Bacterium Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Angiogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Cytolysis By Host Of Symbiont Cells Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Exogenous DsRNA Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Dentinogenesis Cellular Response To Butyrate Amyloid Fibril Formation	Microglial Cell Activation Complement Receptor Mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Receptor-mediated Endocytosis Chemotaxis Inflammatory Response Cell Communication Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Signaling Positive Regulation Of Superoxide Anion Generation Defense Response To Bacterium Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Innate Immune Response Astrocyte Activation Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis Dentinogenesis Cellular Response To Amyloid-beta
Pathways		Neutrophil degranulation Antimicrobial peptides	G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Neutrophil degranulation
Drugs		Selenocysteine
Diseases
GWAS			Alopecia areata ( 25608926) Multiple sclerosis ( 24076602 31604244) Tourette syndrome ( 30818990)
Interacting Genes		9 interacting genes: ACE2 CTSG ELANE F10 F2 FPR2 LBP MAPK8 PRTN3	5 interacting genes: APOD CAMP FXYD6 LRRC25 SSMEM1
Entrez ID		820	2358
HPRD ID		02722	00647
Ensembl ID		ENSG00000164047	ENSG00000171049
Uniprot IDs		A0A384NPR0 J3KNB4 P49913	P25090
PDB IDs		2FBS 2FBU 2FCG 2K6O 2LMF 2NA3 4EYC 5NMN 5NNK 5NNM 5NNT 5XNG 5XRX 6BIV 6BIX 6S6M 7NPQ 7PDC 7SAY 8DEW	6LW5 6OMM 7T6S 7T6U 7T6V 7WVV 7WVW 7WVX 7WVY 8Y62 8Y63
Enriched GO Terms of Interacting Partners?		Response To External Biotic Stimulus Biological Process Involved In Interaction With Symbiont Serine-type Peptidase Activity Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Serine-type Endopeptidase Activity Neutrophil-mediated Killing Of Bacterium Peptidase Activity Neutrophil Mediated Immunity Killing By Host Of Symbiont Cells Regulation Of Reactive Oxygen Species Metabolic Process Response To Other Organism Response To Bacterium Cellular Response To Lipopolysaccharide Regulation Of Inflammatory Response Response To Lipid Neutrophil-mediated Killing Of Gram-negative Bacterium Cellular Response To Molecule Of Bacterial Origin Cellular Response To Oxygen-containing Compound Cell Migration Extracellular Space Acute Inflammatory Response Regulation Of Leukocyte Migration Positive Regulation Of Reactive Oxygen Species Metabolic Process Leukocyte Migration Regulation Of Immune Response Regulation Of Immune System Process Hydrolase Activity Positive Regulation Of Signal Transduction Leukocyte Mediated Cytotoxicity Cell Motility Azurophil Granule Lumen Endopeptidase Activity Angiotensin Maturation Positive Regulation Of Cell Communication Regulation Of Biological Quality Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Defense Response To Bacterium Positive Regulation Of Catalytic Activity Proteolysis Chemotaxis Immune System Process Locomotion Defense Response To Symbiont Regulation Of Intracellular Signal Transduction Killing Of Cells Of Another Organism Defense Response To Other Organism Leukocyte Migration Involved In Inflammatory Response Myeloid Leukocyte Migration	Regulation Of Chemokine Production Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Cellular Response To Butyrate Prostaglandin Production Involved In Inflammatory Response Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Response To Butyrate I-kappaB Phosphorylation Presynaptic Membrane Regulation Of Smooth Muscle Cell-matrix Adhesion Arachidonate Metabolite Production Involved In Inflammatory Response Negative Regulation Of Lipoprotein Metabolic Process Peripheral Nervous System Axon Regeneration Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of T Cell Migration Cellular Response To Peptidoglycan Dentinogenesis Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Antimicrobial Humoral Response Structural Constituent Of Presynaptic Active Zone IkappaB Kinase Complex Ion Channel Regulator Activity Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of Sodium Ion Export Across Plasma Membrane Chronic Inflammatory Response Presynaptic Active Zone Organization Cytolysis By Host Of Symbiont Cells Antifungal Humoral Response Regulation Of Antimicrobial Humoral Response Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Lipoprotein Metabolic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Specific Granule Positive Regulation Of Monocyte Chemotactic Protein-1 Production Production Of Molecular Mediator Involved In Inflammatory Response Cytolysis Response To Peptidoglycan Presynaptic Active Zone Cytoplasmic Component Negative Regulation Of Lymphocyte Migration Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Response To Yeast
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