CAMP and ELANE

Number of citations of the paper that reports this interaction (PubMedID 11389039)
0

Data Source:
HPRD (in vitro)

		CAMP	ELANE
Description		cathelicidin antimicrobial peptide	elastase, neutrophil expressed
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Vesicle Specific Granule Lumen Specific Granule Cell Projection Extracellular Exosome Tertiary Granule Lumen	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Cytosol Cell Surface Transcription Repressor Complex Secretory Granule Extracellular Matrix Cytoplasmic Vesicle Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Lipopolysaccharide Binding Protein Binding	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Cytokine Binding
	Biological Process	Response To Yeast Innate Immune Response In Mucosa Immune System Process Prostaglandin Production Involved In Inflammatory Response Chronic Inflammatory Response Positive Regulation Of Antimicrobial Humoral Response Defense Response Positive Regulation Of Cell Population Proliferation Response To Glucose Leukotriene Biosynthetic Process Antibacterial Humoral Response Antifungal Humoral Response Cytolysis Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Modulation Of Process Of Another Organism Neutrophil Activation Defense Response To Bacterium Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Angiogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Cytolysis By Host Of Symbiont Cells Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Exogenous DsRNA Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Dentinogenesis Cellular Response To Butyrate Amyloid Fibril Formation	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Intracellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Defense Response To Fungus Leukocyte Migration Negative Regulation Of Chemotaxis Pyroptotic Inflammatory Response Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Neutrophil degranulation Antimicrobial peptides	Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Pyroptosis Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade Expression of NOTCH2NL genes
Drugs		Selenocysteine	Alpha-1-proteinase inhibitor Mdl 101,146 Freselestat Elafin Lupeol Ursolic acid
Diseases			Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS			Blood protein levels ( 30072576)
Interacting Genes		9 interacting genes: ACE2 CTSG ELANE F10 F2 FPR2 LBP MAPK8 PRTN3	31 interacting genes: ACE2 CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1
Entrez ID		820	1991
HPRD ID		02722	00554
Ensembl ID		ENSG00000164047	ENSG00000197561
Uniprot IDs		A0A384NPR0 J3KNB4 P49913	P08246
PDB IDs		2FBS 2FBU 2FCG 2K6O 2LMF 2NA3 4EYC 5NMN 5NNK 5NNM 5NNT 5XNG 5XRX 6BIV 6BIX 6S6M 7NPQ 7PDC 7SAY 8DEW	1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK 7WHU 8D4Q 8D4U 8D7I 8D7K 8G24 8G25 8G26 8QGX 8VK5 9ASS 9ASX 9ATK 9ATU
Enriched GO Terms of Interacting Partners?		Response To External Biotic Stimulus Biological Process Involved In Interaction With Symbiont Serine-type Peptidase Activity Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Serine-type Endopeptidase Activity Neutrophil-mediated Killing Of Bacterium Peptidase Activity Neutrophil Mediated Immunity Killing By Host Of Symbiont Cells Regulation Of Reactive Oxygen Species Metabolic Process Response To Other Organism Response To Bacterium Cellular Response To Lipopolysaccharide Regulation Of Inflammatory Response Response To Lipid Neutrophil-mediated Killing Of Gram-negative Bacterium Cellular Response To Molecule Of Bacterial Origin Cellular Response To Oxygen-containing Compound Cell Migration Extracellular Space Acute Inflammatory Response Regulation Of Leukocyte Migration Positive Regulation Of Reactive Oxygen Species Metabolic Process Leukocyte Migration Regulation Of Immune Response Regulation Of Immune System Process Hydrolase Activity Positive Regulation Of Signal Transduction Leukocyte Mediated Cytotoxicity Cell Motility Azurophil Granule Lumen Endopeptidase Activity Angiotensin Maturation Positive Regulation Of Cell Communication Regulation Of Biological Quality Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Defense Response To Bacterium Positive Regulation Of Catalytic Activity Proteolysis Chemotaxis Immune System Process Locomotion Defense Response To Symbiont Regulation Of Intracellular Signal Transduction Killing Of Cells Of Another Organism Defense Response To Other Organism Leukocyte Migration Involved In Inflammatory Response Myeloid Leukocyte Migration	Extracellular Region Peptidase Inhibitor Activity Extracellular Space Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Body Fluid Levels Circulatory System Process Blood Coagulation Coagulation Hemostasis Regulation Of Response To Wounding Extracellular Exosome Extracellular Matrix Regulation Of Wound Healing Defense Response Blood Circulation Inflammatory Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protease Binding Regulation Of Biological Quality Cell Surface Positive Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Proteolysis Negative Regulation Of Plasminogen Activation Positive Regulation Of Coagulation Regulation Of Multicellular Organismal Process Chronic Inflammatory Response Endoplasmic Reticulum Lumen Positive Regulation Of Vasculature Development Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Fibrinolysis Immune System Process External Side Of Plasma Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Proteolysis System Process Positive Regulation Of Interleukin-8 Production Fibrinolysis Signaling Receptor Binding Positive Regulation Of Wound Healing Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Reactive Oxygen Species Metabolic Process
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