CAMP and PRTN3

Number of citations of the paper that reports this interaction (PubMedID 11389039)
0

Data Source:
HPRD (in vivo, in vitro)

		CAMP	PRTN3
Description		cathelicidin antimicrobial peptide	proteinase 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Vesicle Specific Granule Lumen Specific Granule Cell Projection Extracellular Exosome Tertiary Granule Lumen	Extracellular Region Extracellular Space Cytosol Plasma Membrane Membrane Extracellular Matrix Azurophil Granule Lumen Plasma Membrane Raft Membrane Raft Extracellular Exosome
	Molecular Function	Lipopolysaccharide Binding Protein Binding	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Enzyme Binding
	Biological Process	Response To Yeast Innate Immune Response In Mucosa Immune System Process Prostaglandin Production Involved In Inflammatory Response Chronic Inflammatory Response Positive Regulation Of Antimicrobial Humoral Response Defense Response Positive Regulation Of Cell Population Proliferation Response To Glucose Leukotriene Biosynthetic Process Antibacterial Humoral Response Antifungal Humoral Response Cytolysis Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Modulation Of Process Of Another Organism Neutrophil Activation Defense Response To Bacterium Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Angiogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Cytolysis By Host Of Symbiont Cells Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Exogenous DsRNA Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Dentinogenesis Cellular Response To Butyrate Amyloid Fibril Formation	Proteolysis Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cell Population Proliferation Antimicrobial Humoral Response Collagen Catabolic Process Positive Regulation Of GTPase Activity Cell-cell Junction Maintenance Negative Regulation Of Phagocytosis Neutrophil Extravasation Mature Conventional Dendritic Cell Differentiation
Pathways		Neutrophil degranulation Antimicrobial peptides	Common Pathway of Fibrin Clot Formation Other interleukin signaling Neutrophil degranulation Antimicrobial peptides
Drugs		Selenocysteine	Elafin
Diseases
GWAS			Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Blood protein levels ( 30072576) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		9 interacting genes: ACE2 CTSG ELANE F10 F2 FPR2 LBP MAPK8 PRTN3	13 interacting genes: CAMP ELN F2R F2RL1 IL1B IL32 ITGB2 RELA SERPINA1 SERPINB1 SERPINB13 SMAD3 TNF
Entrez ID		820	5657
HPRD ID		02722	01512
Ensembl ID		ENSG00000164047	ENSG00000196415
Uniprot IDs		A0A384NPR0 J3KNB4 P49913	P24158
PDB IDs		2FBS 2FBU 2FCG 2K6O 2LMF 2NA3 4EYC 5NMN 5NNK 5NNM 5NNT 5XNG 5XRX 6BIV 6BIX 6S6M 7NPQ 7PDC 7SAY 8DEW	1FUJ
Enriched GO Terms of Interacting Partners?		Response To External Biotic Stimulus Biological Process Involved In Interaction With Symbiont Serine-type Peptidase Activity Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Serine-type Endopeptidase Activity Neutrophil-mediated Killing Of Bacterium Peptidase Activity Neutrophil Mediated Immunity Killing By Host Of Symbiont Cells Regulation Of Reactive Oxygen Species Metabolic Process Response To Other Organism Response To Bacterium Cellular Response To Lipopolysaccharide Regulation Of Inflammatory Response Response To Lipid Neutrophil-mediated Killing Of Gram-negative Bacterium Cellular Response To Molecule Of Bacterial Origin Cellular Response To Oxygen-containing Compound Cell Migration Extracellular Space Acute Inflammatory Response Regulation Of Leukocyte Migration Positive Regulation Of Reactive Oxygen Species Metabolic Process Leukocyte Migration Regulation Of Immune Response Regulation Of Immune System Process Hydrolase Activity Positive Regulation Of Signal Transduction Leukocyte Mediated Cytotoxicity Cell Motility Azurophil Granule Lumen Endopeptidase Activity Angiotensin Maturation Positive Regulation Of Cell Communication Regulation Of Biological Quality Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Defense Response To Bacterium Positive Regulation Of Catalytic Activity Proteolysis Chemotaxis Immune System Process Locomotion Defense Response To Symbiont Regulation Of Intracellular Signal Transduction Killing Of Cells Of Another Organism Defense Response To Other Organism Leukocyte Migration Involved In Inflammatory Response Myeloid Leukocyte Migration	Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-8 Production Regulation Of Interleukin-8 Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Positive Regulation Of Interleukin-1 Beta Production Inflammatory Response Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Establishment Of Protein Localization Defense Response Positive Regulation Of Establishment Of Protein Localization Regulation Of Interleukin-6 Production Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Cell Activation Positive Regulation Of Chemokine Production Positive Regulation Of Multicellular Organismal Process Regulation Of Protein Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Humoral Immune Response Positive Regulation Of Gene Expression Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Chemokine Production Positive Regulation Of Protein Transport Positive Regulation Of Transport Regulation Of Protein Secretion Immune System Process Negative Regulation Of Apoptotic Process Protease Binding Negative Regulation Of MiRNA Transcription Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization Regulation Of Renin Secretion Into Blood Stream Regulation Of Secretion By Cell Regulation Of Immune Response Response To Lipopolysaccharide Myeloid Leukocyte Activation Regulation Of Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Angiogenesis Regulation Of Wound Healing Regulation Of Vasculature Development Response To Molecule Of Bacterial Origin Regulation Of Secretion Regulation Of Protein Metabolic Process
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