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GANAB and PRRC2A
Number of citations of the paper that reports this interaction (PMID
14667819
)
24
Data Source:
HPRD
(two hybrid)
GANAB
PRRC2A
Gene Name
glucosidase, alpha; neutral AB
proline-rich coiled-coil 2A
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum Lumen
Golgi Apparatus
Membrane
Glucosidase II Complex
Melanosome
Extracellular Vesicular Exosome
Nucleus
Cytoplasm
Membrane
Intracellular Membrane-bounded Organelle
Extracellular Vesicular Exosome
Molecular Function
Carbohydrate Binding
Glucan 1,3-alpha-glucosidase Activity
Poly(A) RNA Binding
Protein Binding
Poly(A) RNA Binding
Biological Process
Protein Folding
Protein N-linked Glycosylation Via Asparagine
Post-translational Protein Modification
Cellular Protein Metabolic Process
Pathways
Defective ALG2 causes ALG2-CDG (CDG-1i)
Diseases of glycosylation
Defective ALG3 causes ALG3-CDG (CDG-1d)
Post-translational protein modification
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Defective ALG1 causes ALG1-CDG (CDG-1k)
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective ALG6 causes ALG6-CDG (CDG-1c)
Defective MOGS causes MOGS-CDG (CDG-2b)
Defective RFT1 causes RFT1-CDG (CDG-1n)
Asparagine N-linked glycosylation
Defective ALG8 causes ALG8-CDG (CDG-1h)
Defective ALG9 causes ALG9-CDG (CDG-1l)
Defective MAN1B1 causes MRT15
Defective MPDU1 causes MPDU1-CDG (CDG-1f)
Defective ALG12 causes ALG12-CDG (CDG-1g)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Defective ALG11 causes ALG11-CDG (CDG-1p)
Diseases associated with N-glycosylation of proteins
Calnexin/calreticulin cycle
Drugs
Diseases
GWAS
Menopause (age at onset) (
22267201
)
Schizophrenia (
23894747
)
Protein-Protein Interactions
7 interactors:
CCNH
CREB3L4
MAPK8
PRKCSH
PRRC2A
PTPRC
RAP1A
27 interactors:
ATN1
ATXN1
C1QBP
CCR10
CPSF1
DDX20
EIF3E
EWSR1
FGA
GANAB
GORASP2
GRB2
HNRNPA1
HNRNPM
IFT88
IMMT
JUN
MAD2L2
MAN2C1
P4HA2
PRMT2
PSMA3
QARS
RBFOX1
RERE
SSR3
UBAP2L
Entrez ID
23193
7916
HPRD ID
03516
00807
Ensembl ID
ENSG00000089597
ENSG00000204469
Uniprot IDs
B4DIW2
B4DSM6
B4DZ53
E9PKU7
F5H6X6
Q14697
P48634
PDB IDs
Enriched GO Terms of Interacting Partners
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Response To Stress
Positive Regulation Of Metabolic Process
Cellular Response To Stimulus
Immunoglobulin Biosynthetic Process
Positive Regulation Of Hematopoietic Stem Cell Migration
Regulation Of Protein Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Regulation Of Kinase Activity
Regulation Of Protein Metabolic Process
Positive Regulation Of Apoptotic Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
JUN Phosphorylation
Neurotrophin Signaling Pathway
Regulation Of Catalytic Activity
Positive Regulation Of Deacetylase Activity
Negative Regulation Of T Cell Mediated Cytotoxicity
Regulation Of Protein Phosphorylation
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Positive Regulation Of Isotype Switching To IgG Isotypes
Bone Marrow Development
Response To Stimulus
Positive Regulation Of Cellular Metabolic Process
Cell Cycle Phase Transition
Positive Regulation Of Determination Of Dorsal Identity
Activation Of Protein Kinase Activity
Positive Regulation Of Gamma-delta T Cell Differentiation
N-glycan Processing
Rap Protein Signal Transduction
Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration
Regulation Of Isotype Switching To IgG Isotypes
Positive Thymic T Cell Selection
Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Gamma-delta T Cell Activation
Regulation Of Phosphorylation
Negative Regulation Of Protein Autophosphorylation
Positive Regulation Of Vasculogenesis
Defense Response
Cellular Response To Nitric Oxide
Nerve Growth Factor Signaling Pathway
Regulation Of Gamma-delta T Cell Differentiation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Negative Regulation Of T Cell Mediated Immunity
Negative Thymic T Cell Selection
Signaling
Regulation Of Neuron Projection Development
Negative Regulation Of Synaptic Vesicle Exocytosis
Negative T Cell Selection
Response To Nitric Oxide
Positive Regulation Of Alpha-beta T Cell Proliferation
Gene Expression
MRNA Metabolic Process
RNA Splicing
RNA Metabolic Process
RNA Processing
MRNA Processing
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Nucleocytoplasmic Transport
Nuclear Transport
Heterocycle Metabolic Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cytoplasmic Transport
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Signal Transduction In Response To DNA Damage
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of RNA Biosynthetic Process
Cellular Aromatic Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Nuclear Export
Nuclear Import
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
RNA Transport
Negative Regulation Of Mitotic Cell Cycle Phase Transition
RNA Localization
Regulation Of Substrate Adhesion-dependent Cell Spreading
Cellular Metabolic Process
Ribonucleoprotein Complex Assembly
Negative Regulation Of Signal Transduction
Glutaminyl-tRNA Aminoacylation
Negative Regulation Of Blood Coagulation, Common Pathway
Blood Coagulation, Common Pathway
Cellular Response To Potassium Ion Starvation
Negative Regulation Of DNA Binding
Negative Regulation Of Signaling
Regulation Of Cell Morphogenesis
Innate Immune Response
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle
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