GANAB and CCNH

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GANAB	CCNH
Gene Name		glucosidase, alpha; neutral AB	cyclin H
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Lumen Golgi Apparatus Membrane Glucosidase II Complex Melanosome Extracellular Vesicular Exosome	Nucleus Nucleoplasm Holo TFIIH Complex Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex TFIIK Complex
	Molecular Function	Carbohydrate Binding Glucan 1,3-alpha-glucosidase Activity Poly(A) RNA Binding	Protein Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Protein Folding Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Gene Expression Viral Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective ALG11 causes ALG11-CDG (CDG-1p) Diseases associated with N-glycosylation of proteins Calnexin/calreticulin cycle	RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Tat-mediated elongation of the HIV-1 transcript Cyclin E associated events during G1/S transition Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression G1/S Transition Mitotic G1-G1/S phases S Phase Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases Transcription of the HIV genome Nucleotide Excision Repair RNA Polymerase II Transcription RNA Polymerase I Transcription Initiation HIV Infection RNA Polymerase I Promoter Clearance Formation of the Early Elongation Complex G2/M Transition RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Cyclin A/B1 associated events during G2/M transition RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER RNA Polymerase I Transcription mRNA Capping RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination G1 Phase Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Cell Cycle, Mitotic Cyclin D associated events in G1 Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Major depressive disorder ( 23377640)
Protein-Protein Interactions		7 interactors: CCNH CREB3L4 MAPK8 PRKCSH PRRC2A PTPRC RAP1A	39 interactors: AR CALCOCO2 CCDC170 CCDC33 CCNC CDK2 CDK20 CDK7 CDK8 CSNK2B CTBP2 CTD DUSP12 ERCC3 ESR1 FUBP1 GANAB GOLGA2 GTF2E2 GTF2H1 KLC3 MBP MCM7 MNAT1 MTA1 MYC NDC80 NEDD4 POLR2A POLR2B PPFIA1 PSMA1 RARB SFN SSSCA1 SSX2IP SUPT5H TP53 TRIM8
Entrez ID		23193	902
HPRD ID		03516	09059
Ensembl ID		ENSG00000089597	ENSG00000134480
Uniprot IDs		B4DIW2 B4DSM6 B4DZ53 E9PKU7 F5H6X6 Q14697	P51946
PDB IDs			1JKW 1KXU
Enriched GO Terms of Interacting Partners?		Response To Stress Positive Regulation Of Metabolic Process Cellular Response To Stimulus Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway JUN Phosphorylation Neurotrophin Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Deacetylase Activity Negative Regulation Of T Cell Mediated Cytotoxicity Regulation Of Protein Phosphorylation Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Response To Stimulus Positive Regulation Of Cellular Metabolic Process Cell Cycle Phase Transition Positive Regulation Of Determination Of Dorsal Identity Activation Of Protein Kinase Activity Positive Regulation Of Gamma-delta T Cell Differentiation N-glycan Processing Rap Protein Signal Transduction Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Regulation Of Isotype Switching To IgG Isotypes Positive Thymic T Cell Selection Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Gamma-delta T Cell Activation Regulation Of Phosphorylation Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Vasculogenesis Defense Response Cellular Response To Nitric Oxide Nerve Growth Factor Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of T Cell Mediated Immunity Negative Thymic T Cell Selection Signaling Regulation Of Neuron Projection Development Negative Regulation Of Synaptic Vesicle Exocytosis Negative T Cell Selection Response To Nitric Oxide Positive Regulation Of Alpha-beta T Cell Proliferation	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine RNA Capping Regulation Of Viral Transcription DNA-templated Transcription, Elongation Positive Regulation Of Viral Transcription Viral Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Viral Process Positive Regulation Of Cellular Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Regulation Of Viral Process Nucleotide-excision Repair Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cell Cycle Cellular Response To Stress Nucleotide-excision Repair, DNA Damage Removal Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cell Cycle Gene Expression Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Transcription Initiation From RNA Polymerase I Promoter Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase I Promoter DNA Repair Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Heterocycle Metabolic Process Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?			carrying chemotherapy conversely ercc5 ercc6 genotype genotypes genotyping good homozygous hrs longer median mms19l months os osteosarcoma pfs polymorphisms poor rflp rs1047768 rs17655 rs29001322 shorter tt undergoing xpc
Tagcloud (Difference) ?			carrying chemotherapy conversely ercc5 ercc6 genotype genotypes genotyping good homozygous hrs longer median mms19l months os osteosarcoma pfs polymorphisms poor rflp rs1047768 rs17655 rs29001322 shorter tt undergoing xpc
Tagcloud (Intersection) ?