GANAB and CREB3L4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GANAB	CREB3L4
Description		glucosidase II alpha subunit	cAMP responsive element binding protein 3 like 4
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Membrane Glucosidase II Complex Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome	Golgi Membrane Chromatin Nucleus Nucleoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Nuclear Membrane
	Molecular Function	RNA Binding Catalytic Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Glucan 1,3-alpha-glucosidase Activity Alpha-glucosidase Activity Glc2Man9GlcNAc2 Oligosaccharide Glucosidase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Carbohydrate Metabolic Process N-glycan Processing	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Spermatogenesis Positive Regulation Of Transcription By RNA Polymerase II
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle Calnexin/calreticulin cycle Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	CREB3 factors activate genes
Drugs		Miglitol
Diseases
GWAS		A body shape index ( 34021172) Hip index ( 34021172) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Age at first birth ( 27798627) Blood protein levels ( 30072576) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Empathy quotient ( 29527006) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: AURKB CCNH CREB3L4 CSNK2A1 LINC01554 MAPK8 PRKCSH PRRC2A PTPRC RAP1A RNF10	5 interacting genes: GANAB GET3 LRRC4C SLC19A3 SOX9
Entrez ID		23193	148327
HPRD ID		03516	06323
Ensembl ID		ENSG00000089597	ENSG00000143578
Uniprot IDs		B4DIW2 B4DSM6 B4DZ53 E9PKU7 F5H6X6 Q14697	Q8TEY5
PDB IDs		8D43 8EMR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Protein Localization To Chromosome Protein Localization To Site Of Double-strand Break	Neural Crest Cell Fate Specification Male Germ-line Sex Determination Negative Regulation Of Beta-catenin-TCF Complex Assembly Bronchus Cartilage Development Ureter Urothelium Development Epithelial Cell Proliferation Involved In Prostatic Bud Elongation Regulation Of Cell Proliferation Involved In Tissue Homeostasis Ureter Smooth Muscle Cell Differentiation Lung Smooth Muscle Development Intrahepatic Bile Duct Development Glc2Man9GlcNAc2 Oligosaccharide Glucosidase Activity Glucan 1,3-alpha-glucosidase Activity Glucosidase II Complex Pyridoxine Transport GET Complex Metanephric Tubule Formation Stem Cell Fate Specification Renal Vesicle Induction Metanephric Nephron Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Chondrocyte Hypertrophy Cell Proliferation Involved In Heart Morphogenesis Trachea Cartilage Development Response To Heparin Prostate Gland Morphogenesis Cellular Response To Heparin Anterior Head Development Primary Sex Determination Harderian Gland Development Astrocyte Fate Commitment Common Bile Duct Development Growth Plate Cartilage Chondrocyte Growth Alpha-glucosidase Activity Thiamine Transmembrane Transporter Activity Thiamine Transport Thiamine Diphosphate Metabolic Process Thiamine Diphosphate Biosynthetic Process Thiamine Transmembrane Transport Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Branching Involved In Lung Morphogenesis Endochondral Bone Morphogenesis Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Lacrimal Gland Development Vitamin Transmembrane Transporter Activity Thiamine-containing Compound Metabolic Process Ureter Development Otic Vesicle Formation Ureter Morphogenesis Glial Cell Fate Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis
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