PBK and ARAF

Number of citations of the paper that reports this interaction (PMID 12620389)
9

Data Source:
HPRD (in vitro)

		PBK	ARAF
Gene Name		PDZ binding kinase	A-Raf proto-oncogene, serine/threonine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component	Cellular_component
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Mitotic Nuclear Division Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To UV Negative Regulation Of Inflammatory Response	Cellular Protein Modification Process Protein Phosphorylation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Negative Regulation Of Apoptotic Process
Pathways
Drugs			Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ARAF CCNB1 CDK1 DLG1 GPRASP1 GPS2 H2AFX KIAA1377 LNX1 RAF1 SMAD4 TERT TP53 TRIM37 ZBTB26 ZFP64	38 interactors: AGTRAP ASS1 BAD CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 GNA12 HRAS IRAK2 IRF7 KLHL12 KRAS MAP2K1 MAP2K2 MLH1 MYO18A NELFCD NUDT14 PBK PDGFRB PIK3R1 PKM PRPF6 RABGGTB RGS12 RRAS RRAS2 TEKT4P2 TESK1 TIMM44 TIRAP WNK1 YWHAG YWHAZ
Entrez ID		55872	369
HPRD ID		17822	02405
Ensembl ID		ENSG00000168078	ENSG00000078061
Uniprot IDs		B4DX68 Q96KB5	B4DV85 P10398 Q96II5
PDB IDs			1WXM
Enriched GO Terms of Interacting Partners?		Cellular Component Assembly Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Chromatin Organization Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Chromosome Organization Protein Complex Assembly Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process DNA Packaging Organelle Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Cell Cycle Cell Cycle Checkpoint Regulation Of Cellular Protein Metabolic Process Cell Aging Regulation Of Signal Transduction Negative Regulation Of Cell Death Cellular Metabolic Process DNA Conformation Change Regulation Of Protein Metabolic Process Cell Cycle Process Response To Hypoxia Negative Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Metabolic Process Replicative Senescence Mitotic Cell Cycle Process Negative Regulation Of Signaling Ventricular Cardiac Muscle Cell Development Regulation Of Protein Kinase Activity Cardiocyte Differentiation Mitotic Cell Cycle Axon Guidance Regulation Of Protein Catabolic Process Regulation Of Kinase Activity Regulation Of Protein Localization Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Negative Regulation Of Gene Expression Mitotic Cell Cycle Checkpoint Cell Projection Morphogenesis Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Cell Cycle	Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Cellular Response To Stimulus Regulation Of Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Cellular Response To Peptide Hormone Stimulus Innate Immune Response Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Motility Regulation Of Signal Transduction Cellular Response To Peptide Cellular Response To Organonitrogen Compound Immune Response Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Regulation Of Locomotion Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Component Movement Signaling Response To Hormone Regulation Of Signaling Cell Communication Toll-like Receptor 4 Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Cell Migration Phosphorylation Response To Stimulus Regulation Of MAPK Cascade Response To Oleic Acid Intrinsic Apoptotic Signaling Pathway Response To Peptide Hormone Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Response To Peptide Positive Regulation Of Cell Motility Toll-like Receptor Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Movement Positive Regulation Of MAP Kinase Activity Cellular Response To Insulin Stimulus
Tagcloud ?		appearance close digit durationxaverage evoked expected exposed exposure industrial kinetic males near nervous neurologic neurotoxic neurotoxicity peak physiologically ppm predictions protect recognition relationships simulated solvent styrene toxicity widely workers	al augmentation braf craf1 die differentiated disruption dramatically drosophila elegans embryos enlarged establish failed finding gestation interacts mek membranes mid mutagenesis programmed ras signalling unlike unpublished vessels w
Tagcloud (Difference) ?		appearance close digit durationxaverage evoked expected exposed exposure industrial kinetic males near nervous neurologic neurotoxic neurotoxicity peak physiologically ppm predictions protect recognition relationships simulated solvent styrene toxicity widely workers	al augmentation braf craf1 die differentiated disruption dramatically drosophila elegans embryos enlarged establish failed finding gestation interacts mek membranes mid mutagenesis programmed ras signalling unlike unpublished vessels w
Tagcloud (Intersection) ?