ARHGAP15 and PRNP

Number of citations of the paper that reports this interaction (PMID 18482256)
4

Data Source:
BioGRID (pull down)

		ARHGAP15	PRNP
Gene Name		Rho GTPase activating protein 15	prion protein
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Nucleus Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Rac GTPase Activator Activity	Copper Ion Binding Protein Binding Microtubule Binding Tubulin Binding Identical Protein Binding ATP-dependent Protein Binding Chaperone Binding
	Biological Process	Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Positive Regulation Of Rac GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Negative Regulation Of Protein Phosphorylation Cellular Copper Ion Homeostasis Response To Oxidative Stress Cell Cycle Arrest Axon Guidance Learning Or Memory Metabolic Process Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Negative Regulation Of T Cell Receptor Signaling Pathway Protein Homooligomerization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Regulation Of Potassium Ion Transmembrane Transport
Pathways		Rho GTPase cycle Signaling by Rho GTPases	NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs			Tetracycline
Diseases
GWAS		Quantitative traits ( 19197348)	Creutzfeldt-Jakob disease ( 19081515) Creutzfeldt-Jakob disease (variant) ( 22137330) Platelet aggregation ( 20526338) Prion diseases ( 22210626)
Protein-Protein Interactions		7 interactors: CD93 KDM1A PRNP RAC1 SMURF1 SNCA TGFBR1	76 interactors: ABT1 ADAM23 ADAP2 AGO1 AIFM3 APBB1 APLP1 APLP2 APOE ARHGAP15 BAG6 BAZ2B C7orf50 CAV1 CCDC149 CIRBP CIRH1A CLSTN1 CLU CNP CNTN1 CSN3 CSNK2A1 CSNK2A2 CSNK2B CWC15 DDX47 DNM1 DPP6 DYRK3 ERI3 FAM27E3 FGF13 FHL1 GRB2 HSPA5 HSPD1 IER3 KIAA1191 L1CAM LSAMP MAG MARK4 MOG MTG1 NCAM1 NCAM2 NHP2 NOB1 OPCML P4HB PDE4DIP PLG PPFIBP2 PPP1R14A PSMA3 PTRH1 PVRL1 RBM22 RNPC3 RPL41 SCNM1 SPARCL1 STIP1 SURF2 TBPL1 TMEM237 TSC22D4 TSLP TYMSOS WDR5 WIBG ZFYVE28 ZKSCAN8 ZNF408 ZNF740
Entrez ID		55843	5621
HPRD ID		06447	01453
Ensembl ID		ENSG00000075884	ENSG00000171867
Uniprot IDs		Q53QZ3	B2NI04 F7VJQ1 P04156 Q53YK7
PDB IDs		3BYI	1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I
Enriched GO Terms of Interacting Partners?		Cellular Response To Copper Ion Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Response To Copper Ion Regulation Of Apoptotic Process Regulation Of Signal Transduction Cell Activation Regulation Of Cell Death Macrophage Activation Regulation Of Signaling Negative Regulation Of Apoptotic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Immune System Process Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Receptor Metabolic Process Regulation Of Cell Activation Regulation Of Immune System Process Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Negative Regulation Of Chromosome Organization Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transferase Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Projection Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Wound Healing Positive Regulation Of Cell Death Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Histone Modification Cellular Response To Metal Ion	Nervous System Development System Development Anatomical Structure Development Axon Development Developmental Process Multicellular Organismal Development Neurogenesis Axon Guidance Generation Of Neurons Axonogenesis Neuron Development Neuron Projection Development Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Regulation Of Protein Metabolic Process Central Nervous System Development Cell Projection Organization Cell Differentiation Cell Projection Morphogenesis Posttranscriptional Regulation Of Gene Expression Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Chemotaxis Cell Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Neurofibrillary Tangle Assembly Locomotion RNA Metabolic Process Apoptotic Process Gene Expression MRNA Metabolic Process Cell Adhesion Programmed Cell Death Cell Death Death Cell Development Response To External Stimulus Movement Of Cell Or Subcellular Component Regulation Of Tau-protein Kinase Activity Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Midbrain Development Regulation Of Protein Catabolic Process Protein Stabilization
Tagcloud ?			chelation cooperatively copper cysteines excitotoxicity exert favor glun1 glun2a glutamatergic hippocampi indeed innovation insults interdependent modulates mounting neurodegeneration neuroprotection nitric nitrosylation nmdar organotypic oxide prion prnp0 prpc synapses thiols
Tagcloud (Difference) ?			chelation cooperatively copper cysteines excitotoxicity exert favor glun1 glun2a glutamatergic hippocampi indeed innovation insults interdependent modulates mounting neurodegeneration neuroprotection nitric nitrosylation nmdar organotypic oxide prion prnp0 prpc synapses thiols
Tagcloud (Intersection) ?