SCN3B and DERL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SCN3B	DERL1
Description		sodium voltage-gated channel beta subunit 3	derlin 1
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GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Cytosol Plasma Membrane Membrane Z Disc Monoatomic Ion Channel Complex	Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Transmembrane Transporter Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential	Protease Binding Signal Recognition Particle Binding Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding Protein-containing Complex Binding ATPase Binding Ubiquitin-specific Protease Binding
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Nervous System Development Positive Regulation Of Heart Rate Positive Regulation Of Sodium Ion Transport Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction	Response To Unfolded Protein Proteasomal Protein Catabolic Process Protein Transport Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Ubiquitination Protein Destabilization Cellular Response To Stress Cellular Response To Unfolded Protein ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Cellular Response To Misfolded Protein
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective CFTR causes cystic fibrosis E3 ubiquitin ligases ubiquitinate target proteins AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs		Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases		Brugada syndrome (BRS)
GWAS		Chronic lymphocytic leukemia ( 23770605 24292274 28165464) Response to citalopram or escitalopram in depression ( 27622933)	Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		116 interacting genes: ADIPOQ AGPAT4 AGPAT5 ANKRD46 AQP10 ARLN ARV1 ATP13A1 ATP6V0C BNIP1 BNIP3 BRICD5 CCDC167 CDIPT CLCA4 CMTM5 CTXN3 CYP4F2 DEFB103A DEFB103B DERL1 DGAT2L6 FAM241B FAM3C FIS1 FKBP8 FXYD3 FXYD6 GIMAP1 GIMAP5 GPR151 GPR61 IER3IP1 INSIG2 ISM2 ITGAM LEMD1 LEPROTL1 LHFPL5 LPAR3 MAL2 MARCHF2 MGST3 MS4A13 NFASC NINJ2 NRM ORMDL1 ORMDL2 PLBD2 PLP2 PLPPR2 PMP22 PNLIPRP1 RHD RNF8 RTP2 RUSF1 SACM1L SCD SEC22A SERP2 SFT2D1 SFXN1 SFXN3 SLC2A5 SLC30A3 SLC30A8 SLC35A4 SLC35E4 SLC38A1 SLC38A7 SLC61A1 SLC7A1 SMCO4 SMIM1 STRIT1 STX3 STX6 STX8 THSD7A TIMM23 TM6SF2 TMBIM6 TMEM120A TMEM120B TMEM128 TMEM140 TMEM14A TMEM14B TMEM203 TMEM208 TMEM239 TMEM243 TMEM42 TMEM50B TMEM60 TMEM65 TMEM86A TMPPE TPRG1 TRARG1 TSPAN2 TVP23B UBIAD1 USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAPA VAPB YIF1A YIPF4 YIPF6 ZFPL1	32 interacting genes: ABHD4 AMFR APP AQP6 CFTR CIAO2A FCRL4 FFAR2 GAD2 HLA-A KASH5 LMNA LNX1 MELTF REEP4 RETREG3 RHO SCN3B SELENOS SLC10A1 SLC10A6 SLC30A8 SLC7A14 SLC7A8 TCF25 TEX44 TMED8 TMEM31 TMX2 TRIM32 UBXN6 VCP
Entrez ID		55800	79139
HPRD ID		10497	12302
Ensembl ID		ENSG00000166257	ENSG00000136986
Uniprot IDs		Q9NY72	E5RGY0 Q9BUN8
PDB IDs		4L1D 7TJ8 7TJ9	5GLF 7CZB 7Y4W 7Y53 7Y59
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Protein Binding Membrane Fusion Organelle Fusion Organelle Membrane Fusion Golgi Vesicle Transport Vesicle-mediated Transport Endomembrane System Vesicle Fusion SNARE Complex Assembly Membrane Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Localization Intracellular Transport Vesicle Organization Establishment Of Localization In Cell Organelle Localization By Membrane Tethering Transmembrane Transport Golgi Membrane Membrane Docking Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Endoplasmic Reticulum Organization Monoatomic Ion Transmembrane Transporter Activity CDP-diacylglycerol Metabolic Process Mitochondrial Outer Membrane Lipid Metabolic Process Synaptic Vesicle To Endosome Fusion FFAT Motif Binding Serine Import Into Mitochondrion Chemical Homeostasis Mitochondrial Membrane Lipid Biosynthetic Process Amino Acid Transmembrane Transport Neutral Amino Acid Transport Synaptic Vesicle Membrane Protein Transport Syntaxin Binding Establishment Of Protein Localization Monoatomic Ion Transport COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Myelination Axon Ensheathment Establishment Of Protein Localization To Plasma Membrane	Derlin-1 Retrotranslocation Complex Ubiquitin-specific Protease Binding BAT3 Complex Binding ERAD Pathway Bile Acid:sodium Symporter Activity Response To Endoplasmic Reticulum Stress Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Endoplasmic Reticulum Membrane Endoplasmic Reticulum Endoplasmic Reticulum Unfolded Protein Response Protein Binding Membrane Positive Regulation Of Chemokine Production Low-density Lipoprotein Particle Organic Anion Transport Golgi-associated Vesicle Membrane Retrograde Protein Transport, ER To Cytosol Early Endosome Membrane Positive Regulation Of Proteolysis Positive Regulation Of Insulin Secretion Very-low-density Lipoprotein Particle Endoplasmic Reticulum Tubular Network Organization Bile Acid And Bile Salt Transport Endoplasmic Reticulum Tubular Network
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